Inflammatory pathways underlying atrial fibrillation
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Inflammatory pathways underlying atrial fibrillation. / Friedrichs, Kai; Klinke, Anna; Baldus, Stephan.
in: TRENDS MOL MED, Jahrgang 17, Nr. 10, 10.2011, S. 556-563.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Inflammatory pathways underlying atrial fibrillation
AU - Friedrichs, Kai
AU - Klinke, Anna
AU - Baldus, Stephan
N1 - Copyright © 2011 Elsevier Ltd. All rights reserved.
PY - 2011/10
Y1 - 2011/10
N2 - The pathophysiology of atrial fibrillation (AF) remains incompletely understood, despite its prevalence and contributing role in stroke and heart failure. Whereas previous studies have focused on the electrophysiological characteristics of AF, recent reports shed light on structural remodeling of the atria as a prerequisite for AF. Recent evidence suggests that atrial fibrosis is linked not only to stimulation of myocytes and fibroblasts, but also to the activation state of leukocytes. Recruitment of leukocytes with the release of reactive oxygen species, cytokines and growth factors is followed by increased matrix deposition, which leads to adverse atrial remodeling and suggests that inflammatory pathways are a prerequisite for AF. Here we review current evidence demonstrating the interrelation between inflammation and AF.
AB - The pathophysiology of atrial fibrillation (AF) remains incompletely understood, despite its prevalence and contributing role in stroke and heart failure. Whereas previous studies have focused on the electrophysiological characteristics of AF, recent reports shed light on structural remodeling of the atria as a prerequisite for AF. Recent evidence suggests that atrial fibrosis is linked not only to stimulation of myocytes and fibroblasts, but also to the activation state of leukocytes. Recruitment of leukocytes with the release of reactive oxygen species, cytokines and growth factors is followed by increased matrix deposition, which leads to adverse atrial remodeling and suggests that inflammatory pathways are a prerequisite for AF. Here we review current evidence demonstrating the interrelation between inflammation and AF.
KW - Animals
KW - Atrial Fibrillation/genetics
KW - Connexins/genetics
KW - Gene Expression Regulation
KW - Humans
KW - Inflammation/genetics
KW - Leukocytes/immunology
U2 - 10.1016/j.molmed.2011.05.007
DO - 10.1016/j.molmed.2011.05.007
M3 - SCORING: Review article
C2 - 21763201
VL - 17
SP - 556
EP - 563
JO - TRENDS MOL MED
JF - TRENDS MOL MED
SN - 1471-4914
IS - 10
ER -