Inflammation triggers ILC3 patrolling of the intestinal barrier

Angélique Jarade; Zacarias Garcia; Solenne Marie; Abdi Demera; Immo Prinz; Philippe Bousso; James P Di Santo; Nicolas Serafini

doi:10.1038/s41590-022-01284-1

Inflammation triggers ILC3 patrolling of the intestinal barrier

Standard

Inflammation triggers ILC3 patrolling of the intestinal barrier. / Jarade, Angélique; Garcia, Zacarias; Marie, Solenne; Demera, Abdi; Prinz, Immo; Bousso, Philippe; Di Santo, James P; Serafini, Nicolas.

in: NAT IMMUNOL, Jahrgang 23, Nr. 9, 09.2022, S. 1317-1323.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › Andere (Vorworte u.ä.) › Forschung

Harvard

Jarade, A, Garcia, Z, Marie, S, Demera, A, Prinz, I, Bousso, P, Di Santo, JP & Serafini, N 2022, 'Inflammation triggers ILC3 patrolling of the intestinal barrier', NAT IMMUNOL, Jg. 23, Nr. 9, S. 1317-1323. https://doi.org/10.1038/s41590-022-01284-1

APA

Jarade, A., Garcia, Z., Marie, S., Demera, A., Prinz, I., Bousso, P., Di Santo, J. P., & Serafini, N. (2022). Inflammation triggers ILC3 patrolling of the intestinal barrier. NAT IMMUNOL, 23(9), 1317-1323. https://doi.org/10.1038/s41590-022-01284-1

Vancouver

Jarade A, Garcia Z, Marie S, Demera A, Prinz I, Bousso P et al. Inflammation triggers ILC3 patrolling of the intestinal barrier. NAT IMMUNOL. 2022 Sep;23(9):1317-1323. https://doi.org/10.1038/s41590-022-01284-1

Bibtex

@article{dbbfc1a2bcd940ce97e7bd6f945b5216,

title = "Inflammation triggers ILC3 patrolling of the intestinal barrier",

abstract = "An orchestrated cellular network, including adaptive lymphocytes and group 3 innate lymphoid cells (ILC3s), maintains intestinal barrier integrity and homeostasis. T cells can monitor environmental insults through constitutive circulation, scanning tissues and forming immunological contacts, a process named immunosurveillance. In contrast, the dynamics of intestinal ILC3s are unknown. Using intravital imaging, we observed that villus ILC3s were largely immotile at steady state but acquired migratory 'patrolling' attributes and enhanced cytokine expression in response to inflammation. We showed that T cells, the chemokine CCL25 and bacterial ligands regulated intestinal ILC3 behavior and that loss of patrolling behavior by interleukin-22 (IL-22)-producing ILC3s altered the intestinal barrier through increased epithelial cell death. Collectively, we identified notable differences between the behavior of ILC3s and T cells, with a prominent adaptation of intestinal ILC3s toward mucosal immunosurveillance after inflammation.",

keywords = "Cytokines/metabolism, Humans, Immunity, Innate, Inflammation/metabolism, Intestinal Mucosa, Ligands, Lymphocytes",

author = "Ang{\'e}lique Jarade and Zacarias Garcia and Solenne Marie and Abdi Demera and Immo Prinz and Philippe Bousso and {Di Santo}, {James P} and Nicolas Serafini",

note = "{\textcopyright} 2022. The Author(s).",

year = "2022",

month = sep,

doi = "10.1038/s41590-022-01284-1",

language = "English",

volume = "23",

pages = "1317--1323",

journal = "NAT IMMUNOL",

issn = "1529-2908",

publisher = "NATURE PUBLISHING GROUP",

number = "9",

}

RIS

TY - JOUR

T1 - Inflammation triggers ILC3 patrolling of the intestinal barrier

AU - Jarade, Angélique

AU - Garcia, Zacarias

AU - Marie, Solenne

AU - Demera, Abdi

AU - Prinz, Immo

AU - Bousso, Philippe

AU - Di Santo, James P

AU - Serafini, Nicolas

PY - 2022/9

Y1 - 2022/9

N2 - An orchestrated cellular network, including adaptive lymphocytes and group 3 innate lymphoid cells (ILC3s), maintains intestinal barrier integrity and homeostasis. T cells can monitor environmental insults through constitutive circulation, scanning tissues and forming immunological contacts, a process named immunosurveillance. In contrast, the dynamics of intestinal ILC3s are unknown. Using intravital imaging, we observed that villus ILC3s were largely immotile at steady state but acquired migratory 'patrolling' attributes and enhanced cytokine expression in response to inflammation. We showed that T cells, the chemokine CCL25 and bacterial ligands regulated intestinal ILC3 behavior and that loss of patrolling behavior by interleukin-22 (IL-22)-producing ILC3s altered the intestinal barrier through increased epithelial cell death. Collectively, we identified notable differences between the behavior of ILC3s and T cells, with a prominent adaptation of intestinal ILC3s toward mucosal immunosurveillance after inflammation.

AB - An orchestrated cellular network, including adaptive lymphocytes and group 3 innate lymphoid cells (ILC3s), maintains intestinal barrier integrity and homeostasis. T cells can monitor environmental insults through constitutive circulation, scanning tissues and forming immunological contacts, a process named immunosurveillance. In contrast, the dynamics of intestinal ILC3s are unknown. Using intravital imaging, we observed that villus ILC3s were largely immotile at steady state but acquired migratory 'patrolling' attributes and enhanced cytokine expression in response to inflammation. We showed that T cells, the chemokine CCL25 and bacterial ligands regulated intestinal ILC3 behavior and that loss of patrolling behavior by interleukin-22 (IL-22)-producing ILC3s altered the intestinal barrier through increased epithelial cell death. Collectively, we identified notable differences between the behavior of ILC3s and T cells, with a prominent adaptation of intestinal ILC3s toward mucosal immunosurveillance after inflammation.

KW - Cytokines/metabolism

KW - Humans

KW - Immunity, Innate

KW - Inflammation/metabolism

KW - Intestinal Mucosa

KW - Ligands

KW - Lymphocytes

U2 - 10.1038/s41590-022-01284-1

DO - 10.1038/s41590-022-01284-1

M3 - Other (editorial matter etc.)

C2 - 35999393

VL - 23

SP - 1317

EP - 1323

JO - NAT IMMUNOL

JF - NAT IMMUNOL

SN - 1529-2908

IS - 9

ER -