Inducing homeostatic-like plasticity in human motor cortex through converging corticocortical inputs
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Inducing homeostatic-like plasticity in human motor cortex through converging corticocortical inputs. / Pötter-Nerger, Monika; Fischer, Sarah; Mastroeni, Claudia; Groppa, Sergiu; Deuschl, Günther; Volkmann, Jens; Quartarone, Angelo; Münchau, Alexander; Siebner, Hartwig Roman.
in: J NEUROPHYSIOL, Jahrgang 102, Nr. 6, 6, 12.2009, S. 3180-3190.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Inducing homeostatic-like plasticity in human motor cortex through converging corticocortical inputs
AU - Pötter-Nerger, Monika
AU - Fischer, Sarah
AU - Mastroeni, Claudia
AU - Groppa, Sergiu
AU - Deuschl, Günther
AU - Volkmann, Jens
AU - Quartarone, Angelo
AU - Münchau, Alexander
AU - Siebner, Hartwig Roman
PY - 2009/12
Y1 - 2009/12
N2 - Transcranial stimulation techniques have revealed homeostatic-like metaplasticity in the hand area of the human primary motor cortex (M1(HAND)) that controls stimulation-induced changes in corticospinal excitability. Here we combined two interventional protocols that induce long-term depression (LTD)-like or long-term potentiation (LTP)-like plasticity in left M1(HAND) through different afferents. We hypothesized that the left M1(HAND) would integrate LTP- and LTD-like plasticity in a homeostatic fashion. In ten healthy volunteers, low-intensity repetitive transcranial magnetic stimulation (rTMS) of the left dorsal premotor cortex (PMD) was first applied to produce an LTP-like increase (5 Hz rTMS) or LTD-like decrease (1 Hz rTMS) in corticospinal excitability in left M1(HAND) via premotor-to-motor inputs. Following PMD rTMS, paired-associative stimulation (PAS) was applied to the right median nerve and left M1(HAND) to induce spike-time-dependent plasticity in sensory-to-motor inputs to left M1(HAND). We adjusted the interstimulus interval to the N20 latency of the median nerve somatosensory-evoked cortical potential to produce an LTP-like increase (PAS(N20+2ms)) or an LTD-like decrease (PAS(N20-5ms)) in corticospinal excitability. The amplitude of motor-evoked potentials was recorded from intrinsic hand muscles to assess stimulation-induced changes in corticospinal excitability. Premotor-to-motor preconditioning triggered a homeostatic response to subsequent sensory-to-motor PAS. After facilitatory 5 Hz rTMS, "facilitatory" PAS(N20+2ms) suppressed corticospinal excitability. Likewise, "inhibitory" PAS(N20-5ms) facilitated corticospinal excitability after "inhibitory" 1 Hz rTMS. There was a negative linear relationship between the excitability changes induced by PMD rTMS and those elicited by subsequent PAS. Excitability changes were not paralleled by changes in performance during a finger-tapping task. These results provide evidence for a homeostatic response pattern in the human M1(HAND) that integrates acute plastic changes evoked through different "input channels."
AB - Transcranial stimulation techniques have revealed homeostatic-like metaplasticity in the hand area of the human primary motor cortex (M1(HAND)) that controls stimulation-induced changes in corticospinal excitability. Here we combined two interventional protocols that induce long-term depression (LTD)-like or long-term potentiation (LTP)-like plasticity in left M1(HAND) through different afferents. We hypothesized that the left M1(HAND) would integrate LTP- and LTD-like plasticity in a homeostatic fashion. In ten healthy volunteers, low-intensity repetitive transcranial magnetic stimulation (rTMS) of the left dorsal premotor cortex (PMD) was first applied to produce an LTP-like increase (5 Hz rTMS) or LTD-like decrease (1 Hz rTMS) in corticospinal excitability in left M1(HAND) via premotor-to-motor inputs. Following PMD rTMS, paired-associative stimulation (PAS) was applied to the right median nerve and left M1(HAND) to induce spike-time-dependent plasticity in sensory-to-motor inputs to left M1(HAND). We adjusted the interstimulus interval to the N20 latency of the median nerve somatosensory-evoked cortical potential to produce an LTP-like increase (PAS(N20+2ms)) or an LTD-like decrease (PAS(N20-5ms)) in corticospinal excitability. The amplitude of motor-evoked potentials was recorded from intrinsic hand muscles to assess stimulation-induced changes in corticospinal excitability. Premotor-to-motor preconditioning triggered a homeostatic response to subsequent sensory-to-motor PAS. After facilitatory 5 Hz rTMS, "facilitatory" PAS(N20+2ms) suppressed corticospinal excitability. Likewise, "inhibitory" PAS(N20-5ms) facilitated corticospinal excitability after "inhibitory" 1 Hz rTMS. There was a negative linear relationship between the excitability changes induced by PMD rTMS and those elicited by subsequent PAS. Excitability changes were not paralleled by changes in performance during a finger-tapping task. These results provide evidence for a homeostatic response pattern in the human M1(HAND) that integrates acute plastic changes evoked through different "input channels."
KW - Adult
KW - Analysis of Variance
KW - Cortical Spreading Depression
KW - Electric Stimulation
KW - Electromyography
KW - Evoked Potentials, Motor
KW - Functional Laterality
KW - Hand
KW - Homeostasis
KW - Humans
KW - Male
KW - Motor Cortex
KW - Muscle, Skeletal
KW - Neuronal Plasticity
KW - Psychomotor Performance
KW - Pyramidal Tracts
KW - Transcranial Magnetic Stimulation
KW - Young Adult
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1152/jn.91046.2008
DO - 10.1152/jn.91046.2008
M3 - SCORING: Journal article
C2 - 19726723
VL - 102
SP - 3180
EP - 3190
JO - J NEUROPHYSIOL
JF - J NEUROPHYSIOL
SN - 0022-3077
IS - 6
M1 - 6
ER -
