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Individual white matter fractional anisotropy analysis on patients with MRI negative partial epilepsy

Standard

Individual white matter fractional anisotropy analysis on patients with MRI negative partial epilepsy. / Duning, Thomas; Kellinghaus, Christoph; Mohammadi, Siawoosh; Schiffbauer, Hagen; Keller, Simon; Ringelstein, E Bernd; Knecht, Stefan; Deppe, Michael.

in: J NEUROL NEUROSUR PS, Jahrgang 81, Nr. 2, 01.02.2010, S. 136-9.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Duning, T, Kellinghaus, C, Mohammadi, S, Schiffbauer, H, Keller, S, Ringelstein, EB, Knecht, S & Deppe, M 2010, 'Individual white matter fractional anisotropy analysis on patients with MRI negative partial epilepsy', J NEUROL NEUROSUR PS, Jg. 81, Nr. 2, S. 136-9. https://doi.org/10.1136/jnnp.2008.160820

APA

Duning, T., Kellinghaus, C., Mohammadi, S., Schiffbauer, H., Keller, S., Ringelstein, E. B., Knecht, S., & Deppe, M. (2010). Individual white matter fractional anisotropy analysis on patients with MRI negative partial epilepsy. J NEUROL NEUROSUR PS, 81(2), 136-9. https://doi.org/10.1136/jnnp.2008.160820

Vancouver

Duning T, Kellinghaus C, Mohammadi S, Schiffbauer H, Keller S, Ringelstein EB et al. Individual white matter fractional anisotropy analysis on patients with MRI negative partial epilepsy. J NEUROL NEUROSUR PS. 2010 Feb 1;81(2):136-9. https://doi.org/10.1136/jnnp.2008.160820

Bibtex

@article{7dc4b4092607448991dadd97dbec997d,
title = "Individual white matter fractional anisotropy analysis on patients with MRI negative partial epilepsy",
abstract = "BACKGROUND: Conventional structural MRI fails to identify a cerebral lesion in 25% of patients with cryptogenic partial epilepsy (CPE). Diffusion tensor imaging is an MRI technique sensitive to microstructural abnormalities of cerebral white matter (WM) by quantification of fractional anisotropy (FA). The objectives of the present study were to identify focal FA abnormalities in patients with CPE who were deemed MRI negative during routine presurgical evaluation.METHODS: Diffusion tensor imaging at 3 T was performed in 12 patients with CPE and normal conventional MRI and in 67 age matched healthy volunteers. WM integrity was compared between groups on the basis of automated voxel-wise statistics of FA maps using an analysis of covariance. Volumetric measurements from high resolution T1-weighted images were also performed.RESULTS: Significant FA reductions in WM regions encompassing diffuse areas of the brain were observed when all patients as a group were compared with controls. On an individual basis, voxel based analyses revealed widespread symmetrical FA reduction in CPE patients. Furthermore, asymmetrical temporal lobe FA reduction was consistently ipsilateral to the electroclinical focus. No significant correlations were found between FA alterations and clinical data. There were no differences in brain volumes of CPE patients compared with controls.CONCLUSION: Despite normal conventional MRI, WM integrity abnormalities in CPE patients extend far beyond the epileptogenic zone. Given that unilateral temporal lobe FA abnormalities were consistently observed ipsilateral to the seizure focus, analysis of temporal FA may provide an informative in vivo investigation into the localisation of the epileptogenic zone in MRI negative patients.",
keywords = "Adult, Anisotropy, Brain, Electroencephalography, Epilepsies, Partial, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Severity of Illness Index",
author = "Thomas Duning and Christoph Kellinghaus and Siawoosh Mohammadi and Hagen Schiffbauer and Simon Keller and Ringelstein, {E Bernd} and Stefan Knecht and Michael Deppe",
year = "2010",
month = feb,
day = "1",
doi = "10.1136/jnnp.2008.160820",
language = "English",
volume = "81",
pages = "136--9",
journal = "J NEUROL NEUROSUR PS",
issn = "0022-3050",
publisher = "BMJ PUBLISHING GROUP",
number = "2",

}

RIS

TY - JOUR

T1 - Individual white matter fractional anisotropy analysis on patients with MRI negative partial epilepsy

AU - Duning, Thomas

AU - Kellinghaus, Christoph

AU - Mohammadi, Siawoosh

AU - Schiffbauer, Hagen

AU - Keller, Simon

AU - Ringelstein, E Bernd

AU - Knecht, Stefan

AU - Deppe, Michael

PY - 2010/2/1

Y1 - 2010/2/1

N2 - BACKGROUND: Conventional structural MRI fails to identify a cerebral lesion in 25% of patients with cryptogenic partial epilepsy (CPE). Diffusion tensor imaging is an MRI technique sensitive to microstructural abnormalities of cerebral white matter (WM) by quantification of fractional anisotropy (FA). The objectives of the present study were to identify focal FA abnormalities in patients with CPE who were deemed MRI negative during routine presurgical evaluation.METHODS: Diffusion tensor imaging at 3 T was performed in 12 patients with CPE and normal conventional MRI and in 67 age matched healthy volunteers. WM integrity was compared between groups on the basis of automated voxel-wise statistics of FA maps using an analysis of covariance. Volumetric measurements from high resolution T1-weighted images were also performed.RESULTS: Significant FA reductions in WM regions encompassing diffuse areas of the brain were observed when all patients as a group were compared with controls. On an individual basis, voxel based analyses revealed widespread symmetrical FA reduction in CPE patients. Furthermore, asymmetrical temporal lobe FA reduction was consistently ipsilateral to the electroclinical focus. No significant correlations were found between FA alterations and clinical data. There were no differences in brain volumes of CPE patients compared with controls.CONCLUSION: Despite normal conventional MRI, WM integrity abnormalities in CPE patients extend far beyond the epileptogenic zone. Given that unilateral temporal lobe FA abnormalities were consistently observed ipsilateral to the seizure focus, analysis of temporal FA may provide an informative in vivo investigation into the localisation of the epileptogenic zone in MRI negative patients.

AB - BACKGROUND: Conventional structural MRI fails to identify a cerebral lesion in 25% of patients with cryptogenic partial epilepsy (CPE). Diffusion tensor imaging is an MRI technique sensitive to microstructural abnormalities of cerebral white matter (WM) by quantification of fractional anisotropy (FA). The objectives of the present study were to identify focal FA abnormalities in patients with CPE who were deemed MRI negative during routine presurgical evaluation.METHODS: Diffusion tensor imaging at 3 T was performed in 12 patients with CPE and normal conventional MRI and in 67 age matched healthy volunteers. WM integrity was compared between groups on the basis of automated voxel-wise statistics of FA maps using an analysis of covariance. Volumetric measurements from high resolution T1-weighted images were also performed.RESULTS: Significant FA reductions in WM regions encompassing diffuse areas of the brain were observed when all patients as a group were compared with controls. On an individual basis, voxel based analyses revealed widespread symmetrical FA reduction in CPE patients. Furthermore, asymmetrical temporal lobe FA reduction was consistently ipsilateral to the electroclinical focus. No significant correlations were found between FA alterations and clinical data. There were no differences in brain volumes of CPE patients compared with controls.CONCLUSION: Despite normal conventional MRI, WM integrity abnormalities in CPE patients extend far beyond the epileptogenic zone. Given that unilateral temporal lobe FA abnormalities were consistently observed ipsilateral to the seizure focus, analysis of temporal FA may provide an informative in vivo investigation into the localisation of the epileptogenic zone in MRI negative patients.

KW - Adult

KW - Anisotropy

KW - Brain

KW - Electroencephalography

KW - Epilepsies, Partial

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Severity of Illness Index

U2 - 10.1136/jnnp.2008.160820

DO - 10.1136/jnnp.2008.160820

M3 - SCORING: Journal article

C2 - 20145026

VL - 81

SP - 136

EP - 139

JO - J NEUROL NEUROSUR PS

JF - J NEUROL NEUROSUR PS

SN - 0022-3050

IS - 2

ER -