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Increasing the sensitivity for stem cell monitoring in system-function based magnetic particle imaging

Standard

Increasing the sensitivity for stem cell monitoring in system-function based magnetic particle imaging. / Them, Kolja; Salamon, J; Szwargulski, P; Sequeira, S; Kaul, M G; Lange, C; Ittrich, H; Knopp, Tobias.

in: PHYS MED BIOL, Jahrgang 61, Nr. 9, 07.05.2016, S. 3279-90.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Them, K, Salamon, J, Szwargulski, P, Sequeira, S, Kaul, MG, Lange, C, Ittrich, H & Knopp, T 2016, 'Increasing the sensitivity for stem cell monitoring in system-function based magnetic particle imaging', PHYS MED BIOL, Jg. 61, Nr. 9, S. 3279-90. https://doi.org/10.1088/0031-9155/61/9/3279

APA

Them, K., Salamon, J., Szwargulski, P., Sequeira, S., Kaul, M. G., Lange, C., Ittrich, H., & Knopp, T. (2016). Increasing the sensitivity for stem cell monitoring in system-function based magnetic particle imaging. PHYS MED BIOL, 61(9), 3279-90. https://doi.org/10.1088/0031-9155/61/9/3279

Vancouver

Them K, Salamon J, Szwargulski P, Sequeira S, Kaul MG, Lange C et al. Increasing the sensitivity for stem cell monitoring in system-function based magnetic particle imaging. PHYS MED BIOL. 2016 Mai 7;61(9):3279-90. https://doi.org/10.1088/0031-9155/61/9/3279

Bibtex

@article{cf6641aa447647ab8607150c92a2ac8e,
title = "Increasing the sensitivity for stem cell monitoring in system-function based magnetic particle imaging",
abstract = "The use of superparamagnetic iron oxide nanoparticles (SPIONs) has provided new possibilities in biophysics and biomedical imaging technologies. The magnetization dynamics of SPIONs, which can be influenced by the environment, are of central interest. In this work, different biological SPION environments are used to investigate three different calibration methods for stem cell monitoring in magnetic particle imaging. It is shown that calibrating using SPIONs immobilized via agarose gel or intracellular uptake results in superior stem cell image quality compared to mobile SPIONs in saline. This superior image quality enables more sensitive localization and identification of a significantly smaller number of magnetically labeled stem cells. The results are important for cell tracking and monitoring of future SPION based therapies such as hyperthermia based cancer therapies, targeted drug delivery, or tissue regeneration approaches where it is crucial to image a sufficiently small number of SPIONs interacting with biological matter.",
keywords = "Journal Article",
author = "Kolja Them and J Salamon and P Szwargulski and S Sequeira and Kaul, {M G} and C Lange and H Ittrich and Tobias Knopp",
year = "2016",
month = may,
day = "7",
doi = "10.1088/0031-9155/61/9/3279",
language = "English",
volume = "61",
pages = "3279--90",
journal = "PHYS MED BIOL",
issn = "0031-9155",
publisher = "IOP Publishing Ltd.",
number = "9",

}

RIS

TY - JOUR

T1 - Increasing the sensitivity for stem cell monitoring in system-function based magnetic particle imaging

AU - Them, Kolja

AU - Salamon, J

AU - Szwargulski, P

AU - Sequeira, S

AU - Kaul, M G

AU - Lange, C

AU - Ittrich, H

AU - Knopp, Tobias

PY - 2016/5/7

Y1 - 2016/5/7

N2 - The use of superparamagnetic iron oxide nanoparticles (SPIONs) has provided new possibilities in biophysics and biomedical imaging technologies. The magnetization dynamics of SPIONs, which can be influenced by the environment, are of central interest. In this work, different biological SPION environments are used to investigate three different calibration methods for stem cell monitoring in magnetic particle imaging. It is shown that calibrating using SPIONs immobilized via agarose gel or intracellular uptake results in superior stem cell image quality compared to mobile SPIONs in saline. This superior image quality enables more sensitive localization and identification of a significantly smaller number of magnetically labeled stem cells. The results are important for cell tracking and monitoring of future SPION based therapies such as hyperthermia based cancer therapies, targeted drug delivery, or tissue regeneration approaches where it is crucial to image a sufficiently small number of SPIONs interacting with biological matter.

AB - The use of superparamagnetic iron oxide nanoparticles (SPIONs) has provided new possibilities in biophysics and biomedical imaging technologies. The magnetization dynamics of SPIONs, which can be influenced by the environment, are of central interest. In this work, different biological SPION environments are used to investigate three different calibration methods for stem cell monitoring in magnetic particle imaging. It is shown that calibrating using SPIONs immobilized via agarose gel or intracellular uptake results in superior stem cell image quality compared to mobile SPIONs in saline. This superior image quality enables more sensitive localization and identification of a significantly smaller number of magnetically labeled stem cells. The results are important for cell tracking and monitoring of future SPION based therapies such as hyperthermia based cancer therapies, targeted drug delivery, or tissue regeneration approaches where it is crucial to image a sufficiently small number of SPIONs interacting with biological matter.

KW - Journal Article

U2 - 10.1088/0031-9155/61/9/3279

DO - 10.1088/0031-9155/61/9/3279

M3 - SCORING: Journal article

C2 - 27032447

VL - 61

SP - 3279

EP - 3290

JO - PHYS MED BIOL

JF - PHYS MED BIOL

SN - 0031-9155

IS - 9

ER -