Increased Resting-State Gamma-Band Connectivity in First-Episode Schizophrenia
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Increased Resting-State Gamma-Band Connectivity in First-Episode Schizophrenia. / Andreou, Christina; Nolte, Guido; Leicht, Gregor; Polomac, Nenad; Hanganu-Opatz, Ileana L; Lambert, Martin; Engel, Andreas K; Mulert, Christoph.
in: SCHIZOPHRENIA BULL, Jahrgang 41, Nr. 4, 07.2015, S. 930-939.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Increased Resting-State Gamma-Band Connectivity in First-Episode Schizophrenia
AU - Andreou, Christina
AU - Nolte, Guido
AU - Leicht, Gregor
AU - Polomac, Nenad
AU - Hanganu-Opatz, Ileana L
AU - Lambert, Martin
AU - Engel, Andreas K
AU - Mulert, Christoph
N1 - © The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.
PY - 2015/7
Y1 - 2015/7
N2 - BACKGROUND: Schizophrenia has long been suggested to represent a disorder with prominent neural dysconnectivity. Gamma-band oscillations are highly relevant in this context, due both to their proposed involvement in neuronal synchronization and to their association with neurotransmitter systems relevant for schizophrenia. Several task-related studies have confirmed reduced power and synchronization of gamma-band oscillations in schizophrenia, but it has been suggested that these findings might not apply to the resting state. The present study aimed to investigate resting-state gamma-band connectivity in patients with schizophrenia.METHODS: Sixty-four channel resting-state electroencephalography (eyes closed) was recorded in 22 patients with first-episode schizophrenia and 22 healthy controls matched for age and gender. Orthogonalized power envelope correlation was used as a measure of connectivity across 80 cortical regions at 40 Hz. Mean connectivity at each region was compared across groups using the nonparametric randomization approach. Additionally, the network-based statistic was applied to identify affected networks in patients.RESULTS: Patients displayed increased mean functional gamma-band connectivity compared to controls in the left rolandic operculum. Network-based analyses indicated increased connectivity in patients within a strongly lateralized network consisting mainly of left inferior frontal/orbitofrontal, lateral and medial temporal, and inferior parietal areas. Within this network, gamma-band connectivity was higher in patients with low positive and disorganization symptom levels.CONCLUSIONS: The present study provides a link between resting-state gamma-band connectivity and the core symptoms of schizophrenia. The observed findings are different than those reported by task-related studies, suggesting that resting-state studies might reveal new aspects in the pathophysiology of schizophrenia.
AB - BACKGROUND: Schizophrenia has long been suggested to represent a disorder with prominent neural dysconnectivity. Gamma-band oscillations are highly relevant in this context, due both to their proposed involvement in neuronal synchronization and to their association with neurotransmitter systems relevant for schizophrenia. Several task-related studies have confirmed reduced power and synchronization of gamma-band oscillations in schizophrenia, but it has been suggested that these findings might not apply to the resting state. The present study aimed to investigate resting-state gamma-band connectivity in patients with schizophrenia.METHODS: Sixty-four channel resting-state electroencephalography (eyes closed) was recorded in 22 patients with first-episode schizophrenia and 22 healthy controls matched for age and gender. Orthogonalized power envelope correlation was used as a measure of connectivity across 80 cortical regions at 40 Hz. Mean connectivity at each region was compared across groups using the nonparametric randomization approach. Additionally, the network-based statistic was applied to identify affected networks in patients.RESULTS: Patients displayed increased mean functional gamma-band connectivity compared to controls in the left rolandic operculum. Network-based analyses indicated increased connectivity in patients within a strongly lateralized network consisting mainly of left inferior frontal/orbitofrontal, lateral and medial temporal, and inferior parietal areas. Within this network, gamma-band connectivity was higher in patients with low positive and disorganization symptom levels.CONCLUSIONS: The present study provides a link between resting-state gamma-band connectivity and the core symptoms of schizophrenia. The observed findings are different than those reported by task-related studies, suggesting that resting-state studies might reveal new aspects in the pathophysiology of schizophrenia.
U2 - 10.1093/schbul/sbu121
DO - 10.1093/schbul/sbu121
M3 - SCORING: Journal article
C2 - 25170031
VL - 41
SP - 930
EP - 939
JO - SCHIZOPHRENIA BULL
JF - SCHIZOPHRENIA BULL
SN - 0586-7614
IS - 4
ER -