Increased peripheral NF-κB pathway activity in women with childhood abuse-related posttraumatic stress disorder.
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Increased peripheral NF-κB pathway activity in women with childhood abuse-related posttraumatic stress disorder. / Pace, Thaddeus W W; Wingenfeld, Katja; Schmidt, Iris; Meinlschmidt, Gunther; Hellhammer, Dirk H; Heim, Christine M.
in: BRAIN BEHAV IMMUN, Jahrgang 26, Nr. 1, 1, 2012, S. 13-17.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Increased peripheral NF-κB pathway activity in women with childhood abuse-related posttraumatic stress disorder.
AU - Pace, Thaddeus W W
AU - Wingenfeld, Katja
AU - Schmidt, Iris
AU - Meinlschmidt, Gunther
AU - Hellhammer, Dirk H
AU - Heim, Christine M
PY - 2012
Y1 - 2012
N2 - In addition to neuroendocrine changes PTSD pathophysiology may also involve dysfunction of the innate immune inflammatory system. PTSD patients have been found to exhibit increased concentrations of circulating inflammatory markers such as C-reactive protein and interleukin-6, suggesting dysfunction of the innate immune inflammatory system. However, few studies have investigated molecular signaling pathways known to critically regulate inflammation. Additionally, the relationship between inflammatory function and immune cell glucocorticoid sensitivity has not been extensively explored in PTSD. Nuclear factor-?B (NF-?B) pathway activity was examined in peripheral blood mononuclear cells obtained from 12 women with childhood abuse-related PTSD and 24 healthy controls (ages 19-48) using DNA-binding ELISA. Glucocorticoid sensitivity of monocytes in whole blood was measured as the concentration of dexamethasone needed to suppress in vitro lipopolysaccharide-induced tumor necrosis factor-alpha production by 50% (DEX IC(50)). Women with PTSD displayed increased NF-?B pathway activity compared to controls (t [34]=2.45, p=0.02) that was positively correlated with PTSD severity (determined by PTSD symptom severity scale) (r(s)=0.39, p=0.02). Increased NF-?B pathway activity was associated with increased whole blood monocyte DEX IC(50) (i.e. decreased sensitivity of monocytes to glucocorticoids) across all participants (r=0.66, p
AB - In addition to neuroendocrine changes PTSD pathophysiology may also involve dysfunction of the innate immune inflammatory system. PTSD patients have been found to exhibit increased concentrations of circulating inflammatory markers such as C-reactive protein and interleukin-6, suggesting dysfunction of the innate immune inflammatory system. However, few studies have investigated molecular signaling pathways known to critically regulate inflammation. Additionally, the relationship between inflammatory function and immune cell glucocorticoid sensitivity has not been extensively explored in PTSD. Nuclear factor-?B (NF-?B) pathway activity was examined in peripheral blood mononuclear cells obtained from 12 women with childhood abuse-related PTSD and 24 healthy controls (ages 19-48) using DNA-binding ELISA. Glucocorticoid sensitivity of monocytes in whole blood was measured as the concentration of dexamethasone needed to suppress in vitro lipopolysaccharide-induced tumor necrosis factor-alpha production by 50% (DEX IC(50)). Women with PTSD displayed increased NF-?B pathway activity compared to controls (t [34]=2.45, p=0.02) that was positively correlated with PTSD severity (determined by PTSD symptom severity scale) (r(s)=0.39, p=0.02). Increased NF-?B pathway activity was associated with increased whole blood monocyte DEX IC(50) (i.e. decreased sensitivity of monocytes to glucocorticoids) across all participants (r=0.66, p
KW - Adult
KW - Humans
KW - Female
KW - Middle Aged
KW - Psychiatric Status Rating Scales
KW - Young Adult
KW - Child
KW - Depression/psychology
KW - Hydrocortisone/blood
KW - Signal Transduction/physiology
KW - Monocytes/metabolism
KW - Adult Survivors of Child Abuse/psychology
KW - Child Abuse, Sexual/psychology
KW - Glucocorticoids/blood
KW - NF-kappa B/metabolism/physiology
KW - Neural Pathways/metabolism
KW - Peripheral Nervous System/metabolism/physiology
KW - Stress Disorders, Post-Traumatic/etiology/physiopathology/psychology
KW - Adult
KW - Humans
KW - Female
KW - Middle Aged
KW - Psychiatric Status Rating Scales
KW - Young Adult
KW - Child
KW - Depression/psychology
KW - Hydrocortisone/blood
KW - Signal Transduction/physiology
KW - Monocytes/metabolism
KW - Adult Survivors of Child Abuse/psychology
KW - Child Abuse, Sexual/psychology
KW - Glucocorticoids/blood
KW - NF-kappa B/metabolism/physiology
KW - Neural Pathways/metabolism
KW - Peripheral Nervous System/metabolism/physiology
KW - Stress Disorders, Post-Traumatic/etiology/physiopathology/psychology
M3 - SCORING: Journal article
VL - 26
SP - 13
EP - 17
JO - BRAIN BEHAV IMMUN
JF - BRAIN BEHAV IMMUN
SN - 0889-1591
IS - 1
M1 - 1
ER -
