Increased osteoblast and osteoclast indices in individuals with systemic mastocytosis
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Increased osteoblast and osteoclast indices in individuals with systemic mastocytosis. / Seitz, S; Barvencik, F; Koehne, T; Priemel, M; Pogoda, P; Semler, J; Minne, H; Pfeiffer, M; Zustin, J; Püschel, K; zu Eulenburg, Christine; Schinke, T; Amling, M.
in: OSTEOPOROSIS INT, Jahrgang 24, Nr. 8, 01.08.2013, S. 2325-34.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Increased osteoblast and osteoclast indices in individuals with systemic mastocytosis
AU - Seitz, S
AU - Barvencik, F
AU - Koehne, T
AU - Priemel, M
AU - Pogoda, P
AU - Semler, J
AU - Minne, H
AU - Pfeiffer, M
AU - Zustin, J
AU - Püschel, K
AU - zu Eulenburg, Christine
AU - Schinke, T
AU - Amling, M
PY - 2013/8/1
Y1 - 2013/8/1
N2 - UNLABELLED: Indolent systemic mastocytosis (ISM) can trigger bone loss. However, the clinical relevance of different mast cell infiltration patterns for bone remains to be clarified. Here, we report increased bone turnover in individuals with ISM, and its extent is rather related to the type of mast cell distribution within the bone marrow than to the presence or absence of cutaneous manifestations.INTRODUCTION: It is well established that ISM can trigger osteopenia or osteoporosis. However, neither the clinical relevance of the infiltration pattern of mast cells within the bone marrow nor the impact of the presence or absence of cutaneous mast cell infiltration has been elucidated.METHODS: We retrospectively analysed 300 cases with histologically proven ISM of the bone marrow and performed quantitative histomorphometry for a subgroup of 159 patients that did not receive any treatment before the biopsies were taken. Most importantly, since 66 % of the patients displayed ISM without the characteristic skin lesions, we were able to compare ISM with or without cutaneous manifestation.RESULTS: We found that both forms of ISM were not only characterized by a decreased trabecular bone mass but also by an increased number of osteoclasts and osteoblasts. Interestingly, when we analysed these data in relation to mast cell distribution, we found that the bone cell numbers in cases with mast cell granulomas were significantly increased compared to cases with diffuse mast cell distribution. Moreover, evidence of increased bone turnover was also found in 16 patients displaying osteosclerosis.CONCLUSION: Based on the largest cohort of bone biopsies from patients with ISM analysed so far, we could demonstrate high bone turnover, more specifically increased osteoblast and osteoclast numbers and surface indices, as a cause of the skeletal changes. Moreover, the severity of the bone disease is presumably rather dependent on the amount of mast cells and their distribution within the bone marrow irrespective of the presence or absence of cutaneous involvement.
AB - UNLABELLED: Indolent systemic mastocytosis (ISM) can trigger bone loss. However, the clinical relevance of different mast cell infiltration patterns for bone remains to be clarified. Here, we report increased bone turnover in individuals with ISM, and its extent is rather related to the type of mast cell distribution within the bone marrow than to the presence or absence of cutaneous manifestations.INTRODUCTION: It is well established that ISM can trigger osteopenia or osteoporosis. However, neither the clinical relevance of the infiltration pattern of mast cells within the bone marrow nor the impact of the presence or absence of cutaneous mast cell infiltration has been elucidated.METHODS: We retrospectively analysed 300 cases with histologically proven ISM of the bone marrow and performed quantitative histomorphometry for a subgroup of 159 patients that did not receive any treatment before the biopsies were taken. Most importantly, since 66 % of the patients displayed ISM without the characteristic skin lesions, we were able to compare ISM with or without cutaneous manifestation.RESULTS: We found that both forms of ISM were not only characterized by a decreased trabecular bone mass but also by an increased number of osteoclasts and osteoblasts. Interestingly, when we analysed these data in relation to mast cell distribution, we found that the bone cell numbers in cases with mast cell granulomas were significantly increased compared to cases with diffuse mast cell distribution. Moreover, evidence of increased bone turnover was also found in 16 patients displaying osteosclerosis.CONCLUSION: Based on the largest cohort of bone biopsies from patients with ISM analysed so far, we could demonstrate high bone turnover, more specifically increased osteoblast and osteoclast numbers and surface indices, as a cause of the skeletal changes. Moreover, the severity of the bone disease is presumably rather dependent on the amount of mast cells and their distribution within the bone marrow irrespective of the presence or absence of cutaneous involvement.
KW - Adult
KW - Age Distribution
KW - Aged
KW - Aged, 80 and over
KW - Biological Markers
KW - Biopsy
KW - Bone Marrow Cells
KW - Bone Remodeling
KW - Cell Count
KW - Female
KW - Germany
KW - Humans
KW - Male
KW - Mast Cells
KW - Mastocytosis, Systemic
KW - Middle Aged
KW - Osteoblasts
KW - Osteoclasts
KW - Prevalence
KW - Retrospective Studies
KW - Sex Distribution
U2 - 10.1007/s00198-013-2305-x
DO - 10.1007/s00198-013-2305-x
M3 - SCORING: Journal article
C2 - 23436077
VL - 24
SP - 2325
EP - 2334
JO - OSTEOPOROSIS INT
JF - OSTEOPOROSIS INT
SN - 0937-941X
IS - 8
ER -
