PortalPublikationenIncreased numbers of CCR5+ interferon-gamma- and tumor necro...

Increased numbers of CCR5+ interferon-gamma- and tumor necrosis factor-alpha-secreting T lymphocytes in multiple sclerosis patients

Standard

Increased numbers of CCR5+ interferon-gamma- and tumor necrosis factor-alpha-secreting T lymphocytes in multiple sclerosis patients. / Strunk, T; Bubel, S; Mascher, B; Schlenke, P; Kirchner, H; Wandinger, K P.

in: ANN NEUROL, Jahrgang 47, Nr. 2, 02.2000, S. 269-273.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › Kurzpublikation › Forschung › Begutachtung

Harvard

Strunk, T, Bubel, S, Mascher, B, Schlenke, P, Kirchner, H & Wandinger, KP 2000, 'Increased numbers of CCR5+ interferon-gamma- and tumor necrosis factor-alpha-secreting T lymphocytes in multiple sclerosis patients', ANN NEUROL, Jg. 47, Nr. 2, S. 269-273. https://doi.org/10.1002/1531-8249(200002)47:2<269::AID-ANA23>3.0.CO;2-G

APA

Strunk, T., Bubel, S., Mascher, B., Schlenke, P., Kirchner, H., & Wandinger, K. P. (2000). Increased numbers of CCR5+ interferon-gamma- and tumor necrosis factor-alpha-secreting T lymphocytes in multiple sclerosis patients. ANN NEUROL, 47(2), 269-273. https://doi.org/10.1002/1531-8249(200002)47:2<269::AID-ANA23>3.0.CO;2-G

Vancouver

Strunk T, Bubel S, Mascher B, Schlenke P, Kirchner H, Wandinger KP. Increased numbers of CCR5+ interferon-gamma- and tumor necrosis factor-alpha-secreting T lymphocytes in multiple sclerosis patients. ANN NEUROL. 2000 Feb;47(2):269-273. https://doi.org/10.1002/1531-8249(200002)47:2<269::AID-ANA23>3.0.CO;2-G

Bibtex

@article{7223384c86f34ee392e1ae250bdaa2f0,
title = "Increased numbers of CCR5+ interferon-gamma- and tumor necrosis factor-alpha-secreting T lymphocytes in multiple sclerosis patients",
abstract = "To determine the frequency of in vivo activated T(H)1 lymphocytes, T-cell subsets of 9 multiple sclerosis patients with active disease and 17 healthy controls were analyzed by immunostaining for CCR5, CD26, and their expression of interleukin-2, interferon-gamma, and tumor necrosis factor-alpha. The numbers of CCR5+ interferon-gamma- and tumor necrosis factor-alpha-producing T cells were significantly increased in the peripheral blood of multiple sclerosis patients. CCR5 expression may be a useful marker to identify effector cells in multiple sclerosis and could be used as a tool for monitoring disease activity.",
keywords = "Adult, Dipeptidyl Peptidase 4/metabolism, Female, Humans, Interferon-gamma/metabolism, Ionomycin/pharmacology, Lymphocyte Count, Male, Middle Aged, Multiple Sclerosis/metabolism, Receptors, CCR5/metabolism, Reference Values, T-Lymphocytes/drug effects, Tetradecanoylphorbol Acetate/pharmacology, Tumor Necrosis Factor-alpha/metabolism",
author = "T Strunk and S Bubel and B Mascher and P Schlenke and H Kirchner and Wandinger, {K P}",
year = "2000",
month = feb,
doi = "10.1002/1531-8249(200002)47:2<269::AID-ANA23>3.0.CO;2-G",
language = "English",
volume = "47",
pages = "269--273",
journal = "ANN NEUROL",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Increased numbers of CCR5+ interferon-gamma- and tumor necrosis factor-alpha-secreting T lymphocytes in multiple sclerosis patients

AU - Strunk, T

AU - Bubel, S

AU - Mascher, B

AU - Schlenke, P

AU - Kirchner, H

AU - Wandinger, K P

PY - 2000/2

Y1 - 2000/2

N2 - To determine the frequency of in vivo activated T(H)1 lymphocytes, T-cell subsets of 9 multiple sclerosis patients with active disease and 17 healthy controls were analyzed by immunostaining for CCR5, CD26, and their expression of interleukin-2, interferon-gamma, and tumor necrosis factor-alpha. The numbers of CCR5+ interferon-gamma- and tumor necrosis factor-alpha-producing T cells were significantly increased in the peripheral blood of multiple sclerosis patients. CCR5 expression may be a useful marker to identify effector cells in multiple sclerosis and could be used as a tool for monitoring disease activity.

AB - To determine the frequency of in vivo activated T(H)1 lymphocytes, T-cell subsets of 9 multiple sclerosis patients with active disease and 17 healthy controls were analyzed by immunostaining for CCR5, CD26, and their expression of interleukin-2, interferon-gamma, and tumor necrosis factor-alpha. The numbers of CCR5+ interferon-gamma- and tumor necrosis factor-alpha-producing T cells were significantly increased in the peripheral blood of multiple sclerosis patients. CCR5 expression may be a useful marker to identify effector cells in multiple sclerosis and could be used as a tool for monitoring disease activity.

KW - Adult

KW - Dipeptidyl Peptidase 4/metabolism

KW - Female

KW - Humans

KW - Interferon-gamma/metabolism

KW - Ionomycin/pharmacology

KW - Lymphocyte Count

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis/metabolism

KW - Receptors, CCR5/metabolism

KW - Reference Values

KW - T-Lymphocytes/drug effects

KW - Tetradecanoylphorbol Acetate/pharmacology

KW - Tumor Necrosis Factor-alpha/metabolism

U2 - 10.1002/1531-8249(200002)47:2<269::AID-ANA23>3.0.CO;2-G

DO - 10.1002/1531-8249(200002)47:2<269::AID-ANA23>3.0.CO;2-G

M3 - Short publication

C2 - 10665504

VL - 47

SP - 269

EP - 273

JO - ANN NEUROL

JF - ANN NEUROL

SN - 0364-5134

IS - 2

ER -