PortalPublikationenIncreased number of microglia in the brain of severe combine...

Increased number of microglia in the brain of severe combined immunodeficient (SCID) mice.

Standard

Increased number of microglia in the brain of severe combined immunodeficient (SCID) mice. / Lorke, Dietrich; Ip, Chi Wang; Schumacher, Udo.

in: HISTOCHEM CELL BIOL, Jahrgang 130, Nr. 4, 4, 2008, S. 693-697.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lorke, D, Ip, CW & Schumacher, U 2008, 'Increased number of microglia in the brain of severe combined immunodeficient (SCID) mice.', HISTOCHEM CELL BIOL, Jg. 130, Nr. 4, 4, S. 693-697. <http://www.ncbi.nlm.nih.gov/pubmed/18600339?dopt=Citation>

APA

Lorke, D., Ip, C. W., & Schumacher, U. (2008). Increased number of microglia in the brain of severe combined immunodeficient (SCID) mice. HISTOCHEM CELL BIOL, 130(4), 693-697. [4]. http://www.ncbi.nlm.nih.gov/pubmed/18600339?dopt=Citation

Vancouver

Lorke D, Ip CW, Schumacher U. Increased number of microglia in the brain of severe combined immunodeficient (SCID) mice. HISTOCHEM CELL BIOL. 2008;130(4):693-697. 4.

Bibtex

@article{e57a5d84e3a244368fe9d7fb34a711c1,
title = "Increased number of microglia in the brain of severe combined immunodeficient (SCID) mice.",
abstract = "To assess the in vivo influence of the systemic immune system upon microglia, six defined brain regions of adult SCID mice (n = 10) lacking functional T- and B-lymphocytes have been analyzed by NDPase histochemistry, morphometry and immunohistochemistry. Despite absence of neuropathology and lack of microglial activation, microglial numerical density was significantly increased in SCID mice. Elevation was most marked in the cerebellar granular layer (by 32.6%; 95% confidence interval: 9.9-58.7%), followed by the fimbria hippocampi and the molecular layer of hippocampal CA1/CA3 region. These data need to be taken into account when using SCID mice as a model for microglial reaction in immunodeficient mice.",
author = "Dietrich Lorke and Ip, {Chi Wang} and Udo Schumacher",
year = "2008",
language = "Deutsch",
volume = "130",
pages = "693--697",
journal = "HISTOCHEM CELL BIOL",
issn = "0948-6143",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Increased number of microglia in the brain of severe combined immunodeficient (SCID) mice.

AU - Lorke, Dietrich

AU - Ip, Chi Wang

AU - Schumacher, Udo

PY - 2008

Y1 - 2008

N2 - To assess the in vivo influence of the systemic immune system upon microglia, six defined brain regions of adult SCID mice (n = 10) lacking functional T- and B-lymphocytes have been analyzed by NDPase histochemistry, morphometry and immunohistochemistry. Despite absence of neuropathology and lack of microglial activation, microglial numerical density was significantly increased in SCID mice. Elevation was most marked in the cerebellar granular layer (by 32.6%; 95% confidence interval: 9.9-58.7%), followed by the fimbria hippocampi and the molecular layer of hippocampal CA1/CA3 region. These data need to be taken into account when using SCID mice as a model for microglial reaction in immunodeficient mice.

AB - To assess the in vivo influence of the systemic immune system upon microglia, six defined brain regions of adult SCID mice (n = 10) lacking functional T- and B-lymphocytes have been analyzed by NDPase histochemistry, morphometry and immunohistochemistry. Despite absence of neuropathology and lack of microglial activation, microglial numerical density was significantly increased in SCID mice. Elevation was most marked in the cerebellar granular layer (by 32.6%; 95% confidence interval: 9.9-58.7%), followed by the fimbria hippocampi and the molecular layer of hippocampal CA1/CA3 region. These data need to be taken into account when using SCID mice as a model for microglial reaction in immunodeficient mice.

M3 - SCORING: Zeitschriftenaufsatz

VL - 130

SP - 693

EP - 697

JO - HISTOCHEM CELL BIOL

JF - HISTOCHEM CELL BIOL

SN - 0948-6143

IS - 4

M1 - 4

ER -