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Increased neural activity during high working memory load predicts low relapse risk in alcohol dependence

Standard

Increased neural activity during high working memory load predicts low relapse risk in alcohol dependence. / Charlet, Katrin; Beck, Anne; Jorde, Anne; Wimmer, Lioba; Vollstädt-Klein, Sabine; Gallinat, Jürgen; Walter, Henrik; Kiefer, Falk; Heinz, Andreas.

in: ADDICT BIOL, Jahrgang 19, Nr. 3, 05.2014, S. 402-14.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Charlet, K, Beck, A, Jorde, A, Wimmer, L, Vollstädt-Klein, S, Gallinat, J, Walter, H, Kiefer, F & Heinz, A 2014, 'Increased neural activity during high working memory load predicts low relapse risk in alcohol dependence', ADDICT BIOL, Jg. 19, Nr. 3, S. 402-14. https://doi.org/10.1111/adb.12103

APA

Charlet, K., Beck, A., Jorde, A., Wimmer, L., Vollstädt-Klein, S., Gallinat, J., Walter, H., Kiefer, F., & Heinz, A. (2014). Increased neural activity during high working memory load predicts low relapse risk in alcohol dependence. ADDICT BIOL, 19(3), 402-14. https://doi.org/10.1111/adb.12103

Vancouver

Charlet K, Beck A, Jorde A, Wimmer L, Vollstädt-Klein S, Gallinat J et al. Increased neural activity during high working memory load predicts low relapse risk in alcohol dependence. ADDICT BIOL. 2014 Mai;19(3):402-14. https://doi.org/10.1111/adb.12103

Bibtex

@article{3b8d6367679f4c309ef966cd70f0fdd0,
title = "Increased neural activity during high working memory load predicts low relapse risk in alcohol dependence",
abstract = "Working memory (WM) impairments are often observed in alcohol-dependent individuals, especially in early abstinence, which may contribute to an increased relapse risk after detoxification. Brain imaging studies on visuospatial WM in alcohol-dependent patients compared to controls indicate that information processing requires compensatory increased neural activation to perform at a normal level. However, to date, no study tested whether such increased neural WM activation patterns or the lack thereof predict relapse behavior in alcohol-dependent individuals, and whether such differences persist when adequately correcting for individual grey matter differences. We combined analyses of neural activation during an n-back task and local grey matter volumes using Biological Parametric Mapping in 40 detoxified alcohol-dependent patients and 40 matched healthy controls (HC), and assessed prospective relapse risk during a 7-month follow-up period. Despite equal task performance, we found increased functional activation during high versus low cognitive WM load (2-back-0-back) in bilateral rostral prefrontal cortex (BA10) and bilateral ventrolateral prefrontal cortex (BA45,47) in prospective abstainers versus relapsers, and further in left/right lateral/medial premotor cortex (BA6,8) in abstainers versus HC. In prospective abstainers, but not relapsers, subtle cognitive impairment was associated with increased neural task activity in the premotor cortex. These findings suggest that in prospective abstainers, higher functional engagement of presumably less impaired neural resources in executive behavioral control brain areas (BA10, 45, 47, 6, 8) may constitute a resilience factor associated with good treatment outcome.",
keywords = "Adolescent, Adult, Aged, Alcohol Abstinence, Alcoholism, Analysis of Variance, Case-Control Studies, Female, Gray Matter, Humans, Magnetic Resonance Imaging, Male, Memory Disorders, Memory, Short-Term, Middle Aged, Motor Cortex, Neuropsychological Tests, Prefrontal Cortex, Psychomotor Performance, Recurrence, Risk Factors, Young Adult",
author = "Katrin Charlet and Anne Beck and Anne Jorde and Lioba Wimmer and Sabine Vollst{\"a}dt-Klein and J{\"u}rgen Gallinat and Henrik Walter and Falk Kiefer and Andreas Heinz",
note = "{\textcopyright} 2013 Society for the Study of Addiction.",
year = "2014",
month = may,
doi = "10.1111/adb.12103",
language = "English",
volume = "19",
pages = "402--14",
journal = "ADDICT BIOL",
issn = "1355-6215",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Increased neural activity during high working memory load predicts low relapse risk in alcohol dependence

AU - Charlet, Katrin

AU - Beck, Anne

AU - Jorde, Anne

AU - Wimmer, Lioba

AU - Vollstädt-Klein, Sabine

AU - Gallinat, Jürgen

AU - Walter, Henrik

AU - Kiefer, Falk

AU - Heinz, Andreas

N1 - © 2013 Society for the Study of Addiction.

PY - 2014/5

Y1 - 2014/5

N2 - Working memory (WM) impairments are often observed in alcohol-dependent individuals, especially in early abstinence, which may contribute to an increased relapse risk after detoxification. Brain imaging studies on visuospatial WM in alcohol-dependent patients compared to controls indicate that information processing requires compensatory increased neural activation to perform at a normal level. However, to date, no study tested whether such increased neural WM activation patterns or the lack thereof predict relapse behavior in alcohol-dependent individuals, and whether such differences persist when adequately correcting for individual grey matter differences. We combined analyses of neural activation during an n-back task and local grey matter volumes using Biological Parametric Mapping in 40 detoxified alcohol-dependent patients and 40 matched healthy controls (HC), and assessed prospective relapse risk during a 7-month follow-up period. Despite equal task performance, we found increased functional activation during high versus low cognitive WM load (2-back-0-back) in bilateral rostral prefrontal cortex (BA10) and bilateral ventrolateral prefrontal cortex (BA45,47) in prospective abstainers versus relapsers, and further in left/right lateral/medial premotor cortex (BA6,8) in abstainers versus HC. In prospective abstainers, but not relapsers, subtle cognitive impairment was associated with increased neural task activity in the premotor cortex. These findings suggest that in prospective abstainers, higher functional engagement of presumably less impaired neural resources in executive behavioral control brain areas (BA10, 45, 47, 6, 8) may constitute a resilience factor associated with good treatment outcome.

AB - Working memory (WM) impairments are often observed in alcohol-dependent individuals, especially in early abstinence, which may contribute to an increased relapse risk after detoxification. Brain imaging studies on visuospatial WM in alcohol-dependent patients compared to controls indicate that information processing requires compensatory increased neural activation to perform at a normal level. However, to date, no study tested whether such increased neural WM activation patterns or the lack thereof predict relapse behavior in alcohol-dependent individuals, and whether such differences persist when adequately correcting for individual grey matter differences. We combined analyses of neural activation during an n-back task and local grey matter volumes using Biological Parametric Mapping in 40 detoxified alcohol-dependent patients and 40 matched healthy controls (HC), and assessed prospective relapse risk during a 7-month follow-up period. Despite equal task performance, we found increased functional activation during high versus low cognitive WM load (2-back-0-back) in bilateral rostral prefrontal cortex (BA10) and bilateral ventrolateral prefrontal cortex (BA45,47) in prospective abstainers versus relapsers, and further in left/right lateral/medial premotor cortex (BA6,8) in abstainers versus HC. In prospective abstainers, but not relapsers, subtle cognitive impairment was associated with increased neural task activity in the premotor cortex. These findings suggest that in prospective abstainers, higher functional engagement of presumably less impaired neural resources in executive behavioral control brain areas (BA10, 45, 47, 6, 8) may constitute a resilience factor associated with good treatment outcome.

KW - Adolescent

KW - Adult

KW - Aged

KW - Alcohol Abstinence

KW - Alcoholism

KW - Analysis of Variance

KW - Case-Control Studies

KW - Female

KW - Gray Matter

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Memory Disorders

KW - Memory, Short-Term

KW - Middle Aged

KW - Motor Cortex

KW - Neuropsychological Tests

KW - Prefrontal Cortex

KW - Psychomotor Performance

KW - Recurrence

KW - Risk Factors

KW - Young Adult

U2 - 10.1111/adb.12103

DO - 10.1111/adb.12103

M3 - SCORING: Journal article

C2 - 24147643

VL - 19

SP - 402

EP - 414

JO - ADDICT BIOL

JF - ADDICT BIOL

SN - 1355-6215

IS - 3

ER -