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Increased lymphocytic Na+/H+ exchange activity after hemodialysis

Standard

Increased lymphocytic Na+/H+ exchange activity after hemodialysis : evidence for an endogenous inhibitor of Na+/H+ exchange in patients with end-stage renal failure. / Tepel, M; Klaus, T; Laukemper, S; Schlüter, H; Zidek, W.

in: LIFE SCI, Jahrgang 59, Nr. 18, 1996, S. 1545-52.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Tepel, M, Klaus, T, Laukemper, S, Schlüter, H & Zidek, W 1996, 'Increased lymphocytic Na+/H+ exchange activity after hemodialysis: evidence for an endogenous inhibitor of Na+/H+ exchange in patients with end-stage renal failure', LIFE SCI, Jg. 59, Nr. 18, S. 1545-52.

APA

Tepel, M., Klaus, T., Laukemper, S., Schlüter, H., & Zidek, W. (1996). Increased lymphocytic Na+/H+ exchange activity after hemodialysis: evidence for an endogenous inhibitor of Na+/H+ exchange in patients with end-stage renal failure. LIFE SCI, 59(18), 1545-52.

Vancouver

Tepel M, Klaus T, Laukemper S, Schlüter H, Zidek W. Increased lymphocytic Na+/H+ exchange activity after hemodialysis: evidence for an endogenous inhibitor of Na+/H+ exchange in patients with end-stage renal failure. LIFE SCI. 1996;59(18):1545-52.

Bibtex

@article{022a1da0e894489da758fa1e6ed8e5a9,
title = "Increased lymphocytic Na+/H+ exchange activity after hemodialysis: evidence for an endogenous inhibitor of Na+/H+ exchange in patients with end-stage renal failure",
abstract = "The Na+/H+ exchange antiport activity was measured in lymphocytes from 16 patients with end-stage renal failure pre- and postdialysis. In addition the effect of the patients' plasma on lymphocytes from healthy subjects was tested. Resting pH (pHi) was not significantly different in lymphocytes pre- and postdialysis. On the other hand, the Na+/H+ exchange activity was significantly lower in lymphocytes before hemodialysis (6.22 +/- 0.73 x 10(-3) pHi/s) than after hemodialysis (9.32 +/- 1.58 x 10(-3) pHi/s; n = 16; p < 0.05). The buffer capacity was not significantly different before and after hemodialysis. The incubation of lymphocytes from healthy control subjects with plasma from patients with end-stage chronic renal failure significantly reduced the lymphocytic Na+/H+ exchange activity. The addition of ultrafiltrate also significantly reduced the Na+/H+ exchange activity in lymphocytes from healthy control subjects. The study indicates the existence of an endogenous inhibitor of the Na+/H+ exchange that is accumulated in plasma from patients with end-stage chronic renal failure.",
keywords = "Adult, Female, Fluoresceins, Fluorescent Dyes, Humans, Hydrogen-Ion Concentration, Kidney Failure, Chronic, Lymphocytes, Male, Renal Replacement Therapy, Sodium-Hydrogen Exchangers, Journal Article",
author = "M Tepel and T Klaus and S Laukemper and H Schl{\"u}ter and W Zidek",
year = "1996",
language = "English",
volume = "59",
pages = "1545--52",
journal = "LIFE SCI",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "18",

}

RIS

TY - JOUR

T1 - Increased lymphocytic Na+/H+ exchange activity after hemodialysis

T2 - evidence for an endogenous inhibitor of Na+/H+ exchange in patients with end-stage renal failure

AU - Tepel, M

AU - Klaus, T

AU - Laukemper, S

AU - Schlüter, H

AU - Zidek, W

PY - 1996

Y1 - 1996

N2 - The Na+/H+ exchange antiport activity was measured in lymphocytes from 16 patients with end-stage renal failure pre- and postdialysis. In addition the effect of the patients' plasma on lymphocytes from healthy subjects was tested. Resting pH (pHi) was not significantly different in lymphocytes pre- and postdialysis. On the other hand, the Na+/H+ exchange activity was significantly lower in lymphocytes before hemodialysis (6.22 +/- 0.73 x 10(-3) pHi/s) than after hemodialysis (9.32 +/- 1.58 x 10(-3) pHi/s; n = 16; p < 0.05). The buffer capacity was not significantly different before and after hemodialysis. The incubation of lymphocytes from healthy control subjects with plasma from patients with end-stage chronic renal failure significantly reduced the lymphocytic Na+/H+ exchange activity. The addition of ultrafiltrate also significantly reduced the Na+/H+ exchange activity in lymphocytes from healthy control subjects. The study indicates the existence of an endogenous inhibitor of the Na+/H+ exchange that is accumulated in plasma from patients with end-stage chronic renal failure.

AB - The Na+/H+ exchange antiport activity was measured in lymphocytes from 16 patients with end-stage renal failure pre- and postdialysis. In addition the effect of the patients' plasma on lymphocytes from healthy subjects was tested. Resting pH (pHi) was not significantly different in lymphocytes pre- and postdialysis. On the other hand, the Na+/H+ exchange activity was significantly lower in lymphocytes before hemodialysis (6.22 +/- 0.73 x 10(-3) pHi/s) than after hemodialysis (9.32 +/- 1.58 x 10(-3) pHi/s; n = 16; p < 0.05). The buffer capacity was not significantly different before and after hemodialysis. The incubation of lymphocytes from healthy control subjects with plasma from patients with end-stage chronic renal failure significantly reduced the lymphocytic Na+/H+ exchange activity. The addition of ultrafiltrate also significantly reduced the Na+/H+ exchange activity in lymphocytes from healthy control subjects. The study indicates the existence of an endogenous inhibitor of the Na+/H+ exchange that is accumulated in plasma from patients with end-stage chronic renal failure.

KW - Adult

KW - Female

KW - Fluoresceins

KW - Fluorescent Dyes

KW - Humans

KW - Hydrogen-Ion Concentration

KW - Kidney Failure, Chronic

KW - Lymphocytes

KW - Male

KW - Renal Replacement Therapy

KW - Sodium-Hydrogen Exchangers

KW - Journal Article

M3 - SCORING: Journal article

C2 - 8890935

VL - 59

SP - 1545

EP - 1552

JO - LIFE SCI

JF - LIFE SCI

SN - 0024-3205

IS - 18

ER -