Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients
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Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients. / Feger, U; Luther, C; Poeschel, S; Melms, A; Tolosa, E; Wiendl, H.
in: CLIN EXP IMMUNOL, Jahrgang 147, Nr. 3, 01.03.2007, S. 412-8.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients
AU - Feger, U
AU - Luther, C
AU - Poeschel, S
AU - Melms, A
AU - Tolosa, E
AU - Wiendl, H
PY - 2007/3/1
Y1 - 2007/3/1
N2 - Naturally occurring CD4+ CD25+ regulatory T cells (nTreg) play a major role in controlling autoimmunity by suppressing self-reactive T cells. Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system (CNS), where T cells play a key role in orchestrating tissue damage. While CD4+ CD25+ nTreg have been investigated in peripheral blood from MS patients, little is known about their presence and possible function within the target organ, the CNS. In order to study whether these cells are present in the cerebrospinal fluid (CSF) under pathological conditions, we have analysed the frequency of CD4+ CD25+ nTreg in peripheral blood and CSF from MS patients (n=14), patients with other neurological disorders (OND; n=9) and compared peripheral levels with healthy controls (n=40). We found that the frequency of CD4+ CD25+ forkhead transcription factor 3 (FOXP3)+ nTreg was significantly elevated in the CSF from MS patients (mean CSF=4 x 05 +/- 1.54% versus mean peripheral blood = 2 x 93 +/- 0 x 94%) but not from patients with other neurological disorders (mean CSF = 3 x 78 +/- 1 x 26% versus mean peripheral blood = 3 x 74 +/- 1 x 4%). The frequency of nTreg in the periphery did not differ between MS patients and healthy donors; however, nTreg from MS patients showed reduced suppressive capacity.
AB - Naturally occurring CD4+ CD25+ regulatory T cells (nTreg) play a major role in controlling autoimmunity by suppressing self-reactive T cells. Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system (CNS), where T cells play a key role in orchestrating tissue damage. While CD4+ CD25+ nTreg have been investigated in peripheral blood from MS patients, little is known about their presence and possible function within the target organ, the CNS. In order to study whether these cells are present in the cerebrospinal fluid (CSF) under pathological conditions, we have analysed the frequency of CD4+ CD25+ nTreg in peripheral blood and CSF from MS patients (n=14), patients with other neurological disorders (OND; n=9) and compared peripheral levels with healthy controls (n=40). We found that the frequency of CD4+ CD25+ forkhead transcription factor 3 (FOXP3)+ nTreg was significantly elevated in the CSF from MS patients (mean CSF=4 x 05 +/- 1.54% versus mean peripheral blood = 2 x 93 +/- 0 x 94%) but not from patients with other neurological disorders (mean CSF = 3 x 78 +/- 1 x 26% versus mean peripheral blood = 3 x 74 +/- 1 x 4%). The frequency of nTreg in the periphery did not differ between MS patients and healthy donors; however, nTreg from MS patients showed reduced suppressive capacity.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Autoimmune Diseases
KW - Cells, Cultured
KW - Female
KW - Forkhead Transcription Factors
KW - Humans
KW - Immune Tolerance
KW - Interleukin-2 Receptor alpha Subunit
KW - Male
KW - Middle Aged
KW - Multiple Sclerosis
KW - Nervous System Diseases
KW - T-Lymphocyte Subsets
KW - T-Lymphocytes, Regulatory
U2 - 10.1111/j.1365-2249.2006.03271.x
DO - 10.1111/j.1365-2249.2006.03271.x
M3 - SCORING: Journal article
C2 - 17302889
VL - 147
SP - 412
EP - 418
JO - CLIN EXP IMMUNOL
JF - CLIN EXP IMMUNOL
SN - 0009-9104
IS - 3
ER -
