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Increased frequency of CD39+ CD56 bright Natural Killer cells in HIV-1 infection correlates with immune activation and disease progression

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Increased frequency of CD39+ CD56 bright Natural Killer cells in HIV-1 infection correlates with immune activation and disease progression. / Dierks, Patrick ; Wroblewski, Raluca; Eberhard, Johanna M; Martrus, Gloria; Degen, Olaf; Hertling, Sandra; Schmiedel, Stefan; Lunemann, Sebastian; Hüfner, Anja; Lohse, Ansgar W; Altfeld, Marcus; van Lunzen, Jan; Schulze Zur Wiesch, Julian.

in: JAIDS-J ACQ IMM DEF, Jahrgang 74, Nr. 4, 04.2017, S. 467-472.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Dierks, P, Wroblewski, R, Eberhard, JM, Martrus, G, Degen, O, Hertling, S, Schmiedel, S, Lunemann, S, Hüfner, A, Lohse, AW, Altfeld, M, van Lunzen, J & Schulze Zur Wiesch, J 2017, 'Increased frequency of CD39+ CD56 bright Natural Killer cells in HIV-1 infection correlates with immune activation and disease progression', JAIDS-J ACQ IMM DEF, Jg. 74, Nr. 4, S. 467-472. https://doi.org/10.1097/QAI.0000000000001266

APA

Dierks, P., Wroblewski, R., Eberhard, J. M., Martrus, G., Degen, O., Hertling, S., Schmiedel, S., Lunemann, S., Hüfner, A., Lohse, A. W., Altfeld, M., van Lunzen, J., & Schulze Zur Wiesch, J. (2017). Increased frequency of CD39+ CD56 bright Natural Killer cells in HIV-1 infection correlates with immune activation and disease progression. JAIDS-J ACQ IMM DEF, 74(4), 467-472. https://doi.org/10.1097/QAI.0000000000001266

Vancouver

Dierks P, Wroblewski R, Eberhard JM, Martrus G, Degen O, Hertling S et al. Increased frequency of CD39+ CD56 bright Natural Killer cells in HIV-1 infection correlates with immune activation and disease progression. JAIDS-J ACQ IMM DEF. 2017 Apr;74(4):467-472. https://doi.org/10.1097/QAI.0000000000001266

Bibtex

@article{9d67816f661d4cc9a62ab199d97c80e6,
title = "Increased frequency of CD39+ CD56 bright Natural Killer cells in HIV-1 infection correlates with immune activation and disease progression",
abstract = "The expression pattern of the ectonucleotidases CD39 and CD73 on NK cells was examined in PBMC of 61 HIV-1 infected patients. Increased frequencies of CD39CD56 NK cells were detectable in untreated HIV patients, which was associated with high viral load, low CD4+ T cell count and CD8+ T cell activation. Additionally, levels of CD39 on NK cells were inducible by in vitro stimulation of NK cells, correlating with Aryl hydrocarbon receptor (AHR) and IL-10 expression. Here, we provide first evidence of increased CD39CD56 NK cell frequencies during HIV infection, which might have consequences for NK cell function and HIV pathogenesis.",
author = "Patrick Dierks and Raluca Wroblewski and Eberhard, {Johanna M} and Gloria Martrus and Olaf Degen and Sandra Hertling and Stefan Schmiedel and Sebastian Lunemann and Anja H{\"u}fner and Lohse, {Ansgar W} and Marcus Altfeld and {van Lunzen}, Jan and {Schulze Zur Wiesch}, Julian",
year = "2017",
month = apr,
doi = "10.1097/QAI.0000000000001266",
language = "English",
volume = "74",
pages = "467--472",
journal = "JAIDS-J ACQ IMM DEF",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - Increased frequency of CD39+ CD56 bright Natural Killer cells in HIV-1 infection correlates with immune activation and disease progression

AU - Dierks, Patrick

AU - Wroblewski, Raluca

AU - Eberhard, Johanna M

AU - Martrus, Gloria

AU - Degen, Olaf

AU - Hertling, Sandra

AU - Schmiedel, Stefan

AU - Lunemann, Sebastian

AU - Hüfner, Anja

AU - Lohse, Ansgar W

AU - Altfeld, Marcus

AU - van Lunzen, Jan

AU - Schulze Zur Wiesch, Julian

PY - 2017/4

Y1 - 2017/4

N2 - The expression pattern of the ectonucleotidases CD39 and CD73 on NK cells was examined in PBMC of 61 HIV-1 infected patients. Increased frequencies of CD39CD56 NK cells were detectable in untreated HIV patients, which was associated with high viral load, low CD4+ T cell count and CD8+ T cell activation. Additionally, levels of CD39 on NK cells were inducible by in vitro stimulation of NK cells, correlating with Aryl hydrocarbon receptor (AHR) and IL-10 expression. Here, we provide first evidence of increased CD39CD56 NK cell frequencies during HIV infection, which might have consequences for NK cell function and HIV pathogenesis.

AB - The expression pattern of the ectonucleotidases CD39 and CD73 on NK cells was examined in PBMC of 61 HIV-1 infected patients. Increased frequencies of CD39CD56 NK cells were detectable in untreated HIV patients, which was associated with high viral load, low CD4+ T cell count and CD8+ T cell activation. Additionally, levels of CD39 on NK cells were inducible by in vitro stimulation of NK cells, correlating with Aryl hydrocarbon receptor (AHR) and IL-10 expression. Here, we provide first evidence of increased CD39CD56 NK cell frequencies during HIV infection, which might have consequences for NK cell function and HIV pathogenesis.

U2 - 10.1097/QAI.0000000000001266

DO - 10.1097/QAI.0000000000001266

M3 - SCORING: Journal article

C2 - 27930600

VL - 74

SP - 467

EP - 472

JO - JAIDS-J ACQ IMM DEF

JF - JAIDS-J ACQ IMM DEF

SN - 1525-4135

IS - 4

ER -