Increased ERCC1 expression is linked to chromosomal aberrations and adverse tumor biology in prostate cancer
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Increased ERCC1 expression is linked to chromosomal aberrations and adverse tumor biology in prostate cancer. / Jacobsen, Frank; Taskin, Billurvan; Melling, Nathaniel; Sauer, Charlotte; Wittmer, Corinna; Hube-Magg, Claudia; Kluth, Martina; Simon, Ronald; Pehrke, Dirk; Beyer, Burkhard; Steuber, Thomas; Thederan, Imke; Sauter, Guido; Schlomm, Thorsten; Wilczak, Waldemar; Möller, Katharina; Weidemann, Sören A; Burdak-Rothkamm, Susanne.
in: BMC CANCER, Jahrgang 17, Nr. 1, 26.07.2017, S. 504.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Increased ERCC1 expression is linked to chromosomal aberrations and adverse tumor biology in prostate cancer
AU - Jacobsen, Frank
AU - Taskin, Billurvan
AU - Melling, Nathaniel
AU - Sauer, Charlotte
AU - Wittmer, Corinna
AU - Hube-Magg, Claudia
AU - Kluth, Martina
AU - Simon, Ronald
AU - Pehrke, Dirk
AU - Beyer, Burkhard
AU - Steuber, Thomas
AU - Thederan, Imke
AU - Sauter, Guido
AU - Schlomm, Thorsten
AU - Wilczak, Waldemar
AU - Möller, Katharina
AU - Weidemann, Sören A
AU - Burdak-Rothkamm, Susanne
PY - 2017/7/26
Y1 - 2017/7/26
N2 - BACKGROUND: Animal model experiments have suggested a role of the DNA repair protein ERCC1 (Excision Repair Cross-Complementation Group 1) in prostate cancer progression.METHODS: To better understand the impact of ERCC1 protein expression in human prostate cancer, a preexisting tissue microarray (TMA) containing more than 12,000 prostate cancer specimens was analyzed by immunohistochemistry and data were compared with tumor phenotype, PSA recurrence and several of the most common genomic alterations (TMPRSS2:ERG fusions: deletions of PTEN, 6q, 5q, 3p).RESULTS: ERCC1 staining was seen in 64.7% of 10,436 interpretable tissues and was considered weak in 37.1%, moderate in 22.6% and strong in 5% of tumors. High-level ERCC1 staining was linked to advanced pT stage, high Gleason grade, positive lymph nodes, high pre-operative serum PSA, and positive surgical margin status (p < 0.0001 each). High ERCC1 expression was strongly associated with an elevated risk of PSA recurrence (p < 0.0001). This was independent of established prognostic features. A subgroup analysis of cancers defined by comparable quantitative Gleason grades revealed that the prognostic impact was mostly driven by low-grade tumors with a Gleason 3 + 3 or 3 + 4 (Gleason 4: ≤5%). High ERCC1 expression was strongly associated with the presence of genomic alterations and expression levels increased with the number of deletions present in the tumor. These latter data suggest a functional relationship of ERCC1 expression with genomic instability.CONCLUSION: The results of our study demonstrate that expression of ERCC1 - a potential surrogate for genomic instability - is an independent prognostic marker in prostate cancer with particular importance in low-grade tumors.
AB - BACKGROUND: Animal model experiments have suggested a role of the DNA repair protein ERCC1 (Excision Repair Cross-Complementation Group 1) in prostate cancer progression.METHODS: To better understand the impact of ERCC1 protein expression in human prostate cancer, a preexisting tissue microarray (TMA) containing more than 12,000 prostate cancer specimens was analyzed by immunohistochemistry and data were compared with tumor phenotype, PSA recurrence and several of the most common genomic alterations (TMPRSS2:ERG fusions: deletions of PTEN, 6q, 5q, 3p).RESULTS: ERCC1 staining was seen in 64.7% of 10,436 interpretable tissues and was considered weak in 37.1%, moderate in 22.6% and strong in 5% of tumors. High-level ERCC1 staining was linked to advanced pT stage, high Gleason grade, positive lymph nodes, high pre-operative serum PSA, and positive surgical margin status (p < 0.0001 each). High ERCC1 expression was strongly associated with an elevated risk of PSA recurrence (p < 0.0001). This was independent of established prognostic features. A subgroup analysis of cancers defined by comparable quantitative Gleason grades revealed that the prognostic impact was mostly driven by low-grade tumors with a Gleason 3 + 3 or 3 + 4 (Gleason 4: ≤5%). High ERCC1 expression was strongly associated with the presence of genomic alterations and expression levels increased with the number of deletions present in the tumor. These latter data suggest a functional relationship of ERCC1 expression with genomic instability.CONCLUSION: The results of our study demonstrate that expression of ERCC1 - a potential surrogate for genomic instability - is an independent prognostic marker in prostate cancer with particular importance in low-grade tumors.
KW - Journal Article
U2 - 10.1186/s12885-017-3489-9
DO - 10.1186/s12885-017-3489-9
M3 - SCORING: Journal article
C2 - 28747165
VL - 17
SP - 504
JO - BMC CANCER
JF - BMC CANCER
SN - 1471-2407
IS - 1
ER -