Increased diversity within the HLA-A*66 group: implications for matching in unrelated bone marrow transplantation.
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Increased diversity within the HLA-A*66 group: implications for matching in unrelated bone marrow transplantation. / Binder, Thomas; Wehling, J; Huhn, D; Blasczyk, R.
in: TISSUE ANTIGENS, Jahrgang 50, Nr. 1, 1, 1997, S. 77-82.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Increased diversity within the HLA-A*66 group: implications for matching in unrelated bone marrow transplantation.
AU - Binder, Thomas
AU - Wehling, J
AU - Huhn, D
AU - Blasczyk, R
PY - 1997
Y1 - 1997
N2 - We have identified a new A*66 allele (A*6603) in three related individuals, an Arabic patient suffering from acute myeloid leukemia and two of her relatives. The A*66 alleles differ in three amino acid residues at positions 70, 90 and 163. The closer relationship between A*6602 and A*6603, which only differ at amino acid 70, replacing GLN with HIS, suggests that the alloreactive potential in this mismatch combination is lower than in all other mismatched A*66 donor-recipient combinations, which exhibit two (A*6601 versus A*6602) and three (A*6601 versus A*6603) differences at the pivotal positions, respectively. This emphasizes the potential role of the A*66 subtypes in bone marrow transplantation with alternative donors. For that reasons, allelic subtyping should be considered in donor-recipient matching to identify the kind of disparity.
AB - We have identified a new A*66 allele (A*6603) in three related individuals, an Arabic patient suffering from acute myeloid leukemia and two of her relatives. The A*66 alleles differ in three amino acid residues at positions 70, 90 and 163. The closer relationship between A*6602 and A*6603, which only differ at amino acid 70, replacing GLN with HIS, suggests that the alloreactive potential in this mismatch combination is lower than in all other mismatched A*66 donor-recipient combinations, which exhibit two (A*6601 versus A*6602) and three (A*6601 versus A*6603) differences at the pivotal positions, respectively. This emphasizes the potential role of the A*66 subtypes in bone marrow transplantation with alternative donors. For that reasons, allelic subtyping should be considered in donor-recipient matching to identify the kind of disparity.
M3 - SCORING: Zeitschriftenaufsatz
VL - 50
SP - 77
EP - 82
JO - TISSUE ANTIGENS
JF - TISSUE ANTIGENS
SN - 0001-2815
IS - 1
M1 - 1
ER -
