Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice.

Zoi Michailidou; Sophie Turban; Eileen Miller; Xiantong Zou; Jörg Schrader; Peter J Ratcliffe; Patrick W F Hadoke; Brian R Walker; John P Iredale; Nicholas M Morton; Jonathan R Seckl

Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice.

Standard

Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice. / Michailidou, Zoi; Turban, Sophie; Miller, Eileen; Zou, Xiantong; Schrader, Jörg; Ratcliffe, Peter J; Hadoke, Patrick W F; Walker, Brian R; Iredale, John P; Morton, Nicholas M; Seckl, Jonathan R.

in: J BIOL CHEM, Jahrgang 287, Nr. 6, 6, 2012, S. 4188-4197.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Michailidou, Z, Turban, S, Miller, E, Zou, X, Schrader, J, Ratcliffe, PJ, Hadoke, PWF, Walker, BR, Iredale, JP, Morton, NM & Seckl, JR 2012, 'Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice.', J BIOL CHEM, Jg. 287, Nr. 6, 6, S. 4188-4197. <http://www.ncbi.nlm.nih.gov/pubmed/22158867?dopt=Citation>

APA

Michailidou, Z., Turban, S., Miller, E., Zou, X., Schrader, J., Ratcliffe, P. J., Hadoke, P. W. F., Walker, B. R., Iredale, J. P., Morton, N. M., & Seckl, J. R. (2012). Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice. J BIOL CHEM, 287(6), 4188-4197. [6]. http://www.ncbi.nlm.nih.gov/pubmed/22158867?dopt=Citation

Vancouver

Michailidou Z, Turban S, Miller E, Zou X, Schrader J, Ratcliffe PJ et al. Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice. J BIOL CHEM. 2012;287(6):4188-4197. 6.

Bibtex

@article{9283d4e2b1ea4b23977901efec2a9655,

title = "Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice.",

abstract = "In obesity, rapidly expanding adipose tissue becomes hypoxic, precipitating inflammation, fibrosis, and insulin resistance. Compensatory angiogenesis may prevent these events. Mice lacking the intracellular glucocorticoid-amplifying enzyme 11?-hydroxysteroid dehydrogenase type 1 (11?HSD1(-/-)) have {"}healthier{"} adipose tissue distribution and resist metabolic disease with diet-induced obesity. Here we show that adipose tissues of 11?HSD1(-/-) mice exhibit attenuated hypoxia, induction of hypoxia-inducible factor (HIF-1?) activation of the TGF-?/Smad3/?-smooth muscle actin (?-SMA) signaling pathway, and fibrogenesis despite similar fat accretion with diet-induced obesity. Moreover, augmented 11?HSD1(-/-) adipose tissue angiogenesis is associated with enhanced peroxisome proliferator-activated receptor ? (PPAR?)-inducible expression of the potent angiogenic factors VEGF-A, apelin, and angiopoietin-like protein 4. Improved adipose angiogenesis and reduced fibrosis provide a novel mechanism whereby suppression of intracellular glucocorticoid regeneration promotes safer fat expansion with weight gain.",

keywords = "Animals, Male, Mice, Mice, Knockout, *Signal Transduction, 11-beta-Hydroxysteroid Dehydrogenase Type 1/*metabolism, Actins/genetics/metabolism, Adipose Tissue/blood supply/*enzymology/pathology, Angiopoietins/genetics/metabolism, Anoxia/*enzymology/pathology/physiopathology, Fibrosis/enzymology/genetics/physiopathology, Hypoxia-Inducible Factor 1, alpha Subunit/genetics/metabolism, Insulin Resistance/genetics, Intercellular Signaling Peptides and Proteins/genetics/metabolism, *Neovascularization, Physiologic, Obesity/*enzymology/pathology/physiopathology, PPAR gamma/genetics/metabolism, Smad3 Protein/genetics/metabolism, Transforming Growth Factor beta/genetics/metabolism, Vascular Endothelial Growth Factor A/genetics/metabolism, Weight Gain/genetics, Animals, Male, Mice, Mice, Knockout, *Signal Transduction, 11-beta-Hydroxysteroid Dehydrogenase Type 1/*metabolism, Actins/genetics/metabolism, Adipose Tissue/blood supply/*enzymology/pathology, Angiopoietins/genetics/metabolism, Anoxia/*enzymology/pathology/physiopathology, Fibrosis/enzymology/genetics/physiopathology, Hypoxia-Inducible Factor 1, alpha Subunit/genetics/metabolism, Insulin Resistance/genetics, Intercellular Signaling Peptides and Proteins/genetics/metabolism, *Neovascularization, Physiologic, Obesity/*enzymology/pathology/physiopathology, PPAR gamma/genetics/metabolism, Smad3 Protein/genetics/metabolism, Transforming Growth Factor beta/genetics/metabolism, Vascular Endothelial Growth Factor A/genetics/metabolism, Weight Gain/genetics",

author = "Zoi Michailidou and Sophie Turban and Eileen Miller and Xiantong Zou and J{\"o}rg Schrader and Ratcliffe, {Peter J} and Hadoke, {Patrick W F} and Walker, {Brian R} and Iredale, {John P} and Morton, {Nicholas M} and Seckl, {Jonathan R}",

year = "2012",

language = "English",

volume = "287",

pages = "4188--4197",

journal = "J BIOL CHEM",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "6",

}

RIS

TY - JOUR

T1 - Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice.

AU - Michailidou, Zoi

AU - Turban, Sophie

AU - Miller, Eileen

AU - Zou, Xiantong

AU - Schrader, Jörg

AU - Ratcliffe, Peter J

AU - Hadoke, Patrick W F

AU - Walker, Brian R

AU - Iredale, John P

AU - Morton, Nicholas M

AU - Seckl, Jonathan R

PY - 2012

Y1 - 2012

N2 - In obesity, rapidly expanding adipose tissue becomes hypoxic, precipitating inflammation, fibrosis, and insulin resistance. Compensatory angiogenesis may prevent these events. Mice lacking the intracellular glucocorticoid-amplifying enzyme 11?-hydroxysteroid dehydrogenase type 1 (11?HSD1(-/-)) have "healthier" adipose tissue distribution and resist metabolic disease with diet-induced obesity. Here we show that adipose tissues of 11?HSD1(-/-) mice exhibit attenuated hypoxia, induction of hypoxia-inducible factor (HIF-1?) activation of the TGF-?/Smad3/?-smooth muscle actin (?-SMA) signaling pathway, and fibrogenesis despite similar fat accretion with diet-induced obesity. Moreover, augmented 11?HSD1(-/-) adipose tissue angiogenesis is associated with enhanced peroxisome proliferator-activated receptor ? (PPAR?)-inducible expression of the potent angiogenic factors VEGF-A, apelin, and angiopoietin-like protein 4. Improved adipose angiogenesis and reduced fibrosis provide a novel mechanism whereby suppression of intracellular glucocorticoid regeneration promotes safer fat expansion with weight gain.

AB - In obesity, rapidly expanding adipose tissue becomes hypoxic, precipitating inflammation, fibrosis, and insulin resistance. Compensatory angiogenesis may prevent these events. Mice lacking the intracellular glucocorticoid-amplifying enzyme 11?-hydroxysteroid dehydrogenase type 1 (11?HSD1(-/-)) have "healthier" adipose tissue distribution and resist metabolic disease with diet-induced obesity. Here we show that adipose tissues of 11?HSD1(-/-) mice exhibit attenuated hypoxia, induction of hypoxia-inducible factor (HIF-1?) activation of the TGF-?/Smad3/?-smooth muscle actin (?-SMA) signaling pathway, and fibrogenesis despite similar fat accretion with diet-induced obesity. Moreover, augmented 11?HSD1(-/-) adipose tissue angiogenesis is associated with enhanced peroxisome proliferator-activated receptor ? (PPAR?)-inducible expression of the potent angiogenic factors VEGF-A, apelin, and angiopoietin-like protein 4. Improved adipose angiogenesis and reduced fibrosis provide a novel mechanism whereby suppression of intracellular glucocorticoid regeneration promotes safer fat expansion with weight gain.

KW - Animals

KW - Male

KW - Mice

KW - Mice, Knockout

KW - Signal Transduction

KW - 11-beta-Hydroxysteroid Dehydrogenase Type 1/metabolism

KW - Actins/genetics/metabolism

KW - Adipose Tissue/blood supply/enzymology/pathology

KW - Angiopoietins/genetics/metabolism

KW - Anoxia/enzymology/pathology/physiopathology

KW - Fibrosis/enzymology/genetics/physiopathology

KW - Hypoxia-Inducible Factor 1, alpha Subunit/genetics/metabolism

KW - Insulin Resistance/genetics

KW - Intercellular Signaling Peptides and Proteins/genetics/metabolism

KW - Neovascularization, Physiologic

KW - Obesity/enzymology/pathology/physiopathology

KW - PPAR gamma/genetics/metabolism

KW - Smad3 Protein/genetics/metabolism

KW - Transforming Growth Factor beta/genetics/metabolism

KW - Vascular Endothelial Growth Factor A/genetics/metabolism

KW - Weight Gain/genetics

KW - Animals

KW - Male

KW - Mice

KW - Mice, Knockout

KW - Signal Transduction

KW - 11-beta-Hydroxysteroid Dehydrogenase Type 1/metabolism

KW - Actins/genetics/metabolism

KW - Adipose Tissue/blood supply/enzymology/pathology

KW - Angiopoietins/genetics/metabolism

KW - Anoxia/enzymology/pathology/physiopathology

KW - Fibrosis/enzymology/genetics/physiopathology

KW - Hypoxia-Inducible Factor 1, alpha Subunit/genetics/metabolism

KW - Insulin Resistance/genetics

KW - Intercellular Signaling Peptides and Proteins/genetics/metabolism

KW - Neovascularization, Physiologic

KW - Obesity/enzymology/pathology/physiopathology

KW - PPAR gamma/genetics/metabolism

KW - Smad3 Protein/genetics/metabolism

KW - Transforming Growth Factor beta/genetics/metabolism

KW - Vascular Endothelial Growth Factor A/genetics/metabolism

KW - Weight Gain/genetics

M3 - SCORING: Journal article

VL - 287

SP - 4188

EP - 4197

JO - J BIOL CHEM

JF - J BIOL CHEM

SN - 0021-9258

IS - 6

M1 - 6

ER -