Increased γ oscillations during voluntary selection processes in adult patients with attention deficit/hyperactivity disorder.
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Increased γ oscillations during voluntary selection processes in adult patients with attention deficit/hyperactivity disorder. / Karch, Susanne; Segmiller, Felix; Hantschk, Irmgard; Cerovecki, Anja; Opgen-Rhein, Markus; Hock, Bettina; Dargel, Sascha; Leicht, Gregor; Hennig-Fast, Kristina; Riedel, Michael; Pogarell, Oliver.
in: J PSYCHIATR RES, Jahrgang 46, Nr. 11, 11, 2012, S. 1515-1523.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Increased γ oscillations during voluntary selection processes in adult patients with attention deficit/hyperactivity disorder.
AU - Karch, Susanne
AU - Segmiller, Felix
AU - Hantschk, Irmgard
AU - Cerovecki, Anja
AU - Opgen-Rhein, Markus
AU - Hock, Bettina
AU - Dargel, Sascha
AU - Leicht, Gregor
AU - Hennig-Fast, Kristina
AU - Riedel, Michael
AU - Pogarell, Oliver
PY - 2012
Y1 - 2012
N2 - Executive dysfunctions (regarding behavioural inhibition, decision making, flexibility or voluntary selection) rank among the core symptoms of attention deficit/hyperactivity disorder. Several studies demonstrated functional variations in patients with ADHD especially during response inhibition and flexibility. However, information about functional correlates of other aspects of executive functions such as voluntary selection processes is limited. A group of thirty adult patients with attention deficit/hyperactivity disorder (ADHD) and 30 healthy controls, matched for age and education, participated in the present study. Electrophysiological responses (event-related potentials, gamma oscillations) and behavioural data were acquired during the voluntary selection between various response alternatives. ADHD patients demonstrated increased responses in the gamma frequency band especially in frontal and fronto-central brain areas during voluntary response selection processes compared to healthy subjects. In addition, the error rate was increased in patients. Given that gamma-band responses have been related to GABAergic and glutamatergic responses these results may indicate accordant dysfunction in patients with ADHD.
AB - Executive dysfunctions (regarding behavioural inhibition, decision making, flexibility or voluntary selection) rank among the core symptoms of attention deficit/hyperactivity disorder. Several studies demonstrated functional variations in patients with ADHD especially during response inhibition and flexibility. However, information about functional correlates of other aspects of executive functions such as voluntary selection processes is limited. A group of thirty adult patients with attention deficit/hyperactivity disorder (ADHD) and 30 healthy controls, matched for age and education, participated in the present study. Electrophysiological responses (event-related potentials, gamma oscillations) and behavioural data were acquired during the voluntary selection between various response alternatives. ADHD patients demonstrated increased responses in the gamma frequency band especially in frontal and fronto-central brain areas during voluntary response selection processes compared to healthy subjects. In addition, the error rate was increased in patients. Given that gamma-band responses have been related to GABAergic and glutamatergic responses these results may indicate accordant dysfunction in patients with ADHD.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Adolescent
KW - Young Adult
KW - Neuropsychological Tests
KW - Wechsler Scales
KW - Brain Waves/physiology
KW - Electroencephalography/methods
KW - Inhibition (Psychology)
KW - Attention Deficit Disorder with Hyperactivity/physiopathology
KW - Executive Function/physiology
KW - Up-Regulation/physiology
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Adolescent
KW - Young Adult
KW - Neuropsychological Tests
KW - Wechsler Scales
KW - Brain Waves/physiology
KW - Electroencephalography/methods
KW - Inhibition (Psychology)
KW - Attention Deficit Disorder with Hyperactivity/physiopathology
KW - Executive Function/physiology
KW - Up-Regulation/physiology
M3 - SCORING: Journal article
VL - 46
SP - 1515
EP - 1523
JO - J PSYCHIATR RES
JF - J PSYCHIATR RES
SN - 0022-3956
IS - 11
M1 - 11
ER -
