Incident Subjective Cognitive Decline Does Not Predict Mortality in the Elderly - Results from the Longitudinal German Study on Ageing, Cognition, and Dementia (AgeCoDe)
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Incident Subjective Cognitive Decline Does Not Predict Mortality in the Elderly - Results from the Longitudinal German Study on Ageing, Cognition, and Dementia (AgeCoDe). / Roehr, Susanne; Luck, Tobias; Heser, Kathrin; Fuchs, Angela; Ernst, Annette; Wiese, Birgitt; Werle, Jochen; Bickel, Horst; Brettschneider, Christian; Koppara, Alexander; Pentzek, Michael; Lange, Carolin; Prokein, Jana; Weyerer, Siegfried; Mösch, Edelgard; König, Hans-Helmut; Maier, Wolfgang; Scherer, Martin; Jessen, Frank; Riedel-Heller, Steffi G.
in: PLOS ONE, Jahrgang 11, Nr. 1, 2016, S. e0147050.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Incident Subjective Cognitive Decline Does Not Predict Mortality in the Elderly - Results from the Longitudinal German Study on Ageing, Cognition, and Dementia (AgeCoDe)
AU - Roehr, Susanne
AU - Luck, Tobias
AU - Heser, Kathrin
AU - Fuchs, Angela
AU - Ernst, Annette
AU - Wiese, Birgitt
AU - Werle, Jochen
AU - Bickel, Horst
AU - Brettschneider, Christian
AU - Koppara, Alexander
AU - Pentzek, Michael
AU - Lange, Carolin
AU - Prokein, Jana
AU - Weyerer, Siegfried
AU - Mösch, Edelgard
AU - König, Hans-Helmut
AU - Maier, Wolfgang
AU - Scherer, Martin
AU - Jessen, Frank
AU - Riedel-Heller, Steffi G
PY - 2016
Y1 - 2016
N2 - OBJECTIVE: Subjective cognitive decline (SCD) might represent the first symptomatic representation of Alzheimer's disease (AD), which is associated with increased mortality. Only few studies, however, have analyzed the association of SCD and mortality, and if so, based on prevalent cases. Thus, we investigated incident SCD in memory and mortality.METHODS: Data were derived from the German AgeCoDe study, a prospective longitudinal study on the epidemiology of mild cognitive impairment (MCI) and dementia in primary care patients over 75 years covering an observation period of 7.5 years. We used univariate and multivariate Cox regression analyses to examine the relationship of SCD and mortality. Further, we estimated survival times by the Kaplan Meier method and case-fatality rates with regard to SCD.RESULTS: Among 971 individuals without objective cognitive impairment, 233 (24.0%) incidentally expressed SCD at follow-up I. Incident SCD was not significantly associated with increased mortality in the univariate (HR = 1.0, 95% confidence interval = 0.8-1.3, p = .90) as well as in the multivariate analysis (HR = 0.9, 95% confidence interval = 0.7-1.2, p = .40). The same applied for SCD in relation to concerns. Mean survival time with SCD was 8.0 years (SD = 0.1) after onset.CONCLUSION: Incident SCD in memory in individuals with unimpaired cognitive performance does not predict mortality. The main reason might be that SCD does not ultimately lead into future cognitive decline in any case. However, as prevalence studies suggest, subjectively perceived decline in non-memory cognitive domains might be associated with increased mortality. Future studies may address mortality in such other cognitive domains of SCD in incident cases.
AB - OBJECTIVE: Subjective cognitive decline (SCD) might represent the first symptomatic representation of Alzheimer's disease (AD), which is associated with increased mortality. Only few studies, however, have analyzed the association of SCD and mortality, and if so, based on prevalent cases. Thus, we investigated incident SCD in memory and mortality.METHODS: Data were derived from the German AgeCoDe study, a prospective longitudinal study on the epidemiology of mild cognitive impairment (MCI) and dementia in primary care patients over 75 years covering an observation period of 7.5 years. We used univariate and multivariate Cox regression analyses to examine the relationship of SCD and mortality. Further, we estimated survival times by the Kaplan Meier method and case-fatality rates with regard to SCD.RESULTS: Among 971 individuals without objective cognitive impairment, 233 (24.0%) incidentally expressed SCD at follow-up I. Incident SCD was not significantly associated with increased mortality in the univariate (HR = 1.0, 95% confidence interval = 0.8-1.3, p = .90) as well as in the multivariate analysis (HR = 0.9, 95% confidence interval = 0.7-1.2, p = .40). The same applied for SCD in relation to concerns. Mean survival time with SCD was 8.0 years (SD = 0.1) after onset.CONCLUSION: Incident SCD in memory in individuals with unimpaired cognitive performance does not predict mortality. The main reason might be that SCD does not ultimately lead into future cognitive decline in any case. However, as prevalence studies suggest, subjectively perceived decline in non-memory cognitive domains might be associated with increased mortality. Future studies may address mortality in such other cognitive domains of SCD in incident cases.
U2 - 10.1371/journal.pone.0147050
DO - 10.1371/journal.pone.0147050
M3 - SCORING: Journal article
C2 - 26766555
VL - 11
SP - e0147050
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 1
ER -
