Incidence rates and contemporary trends in primary urethral cancer
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Incidence rates and contemporary trends in primary urethral cancer. / Wenzel, Mike; Nocera, Luigi; Collà Ruvolo, Claudia; Würnschimmel, Christoph; Tian, Zhe; Shariat, Shahrokh F; Saad, Fred; Briganti, Alberto; Tilki, Derya; Mandel, Philipp; Becker, Andreas; Kluth, Luis A; Chun, Felix K H; Karakiewicz, Pierre I.
in: CANCER CAUSE CONTROL, Jahrgang 32, Nr. 6, 06.2021, S. 627-634.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Incidence rates and contemporary trends in primary urethral cancer
AU - Wenzel, Mike
AU - Nocera, Luigi
AU - Collà Ruvolo, Claudia
AU - Würnschimmel, Christoph
AU - Tian, Zhe
AU - Shariat, Shahrokh F
AU - Saad, Fred
AU - Briganti, Alberto
AU - Tilki, Derya
AU - Mandel, Philipp
AU - Becker, Andreas
AU - Kluth, Luis A
AU - Chun, Felix K H
AU - Karakiewicz, Pierre I
PY - 2021/6
Y1 - 2021/6
N2 - PURPOSE: We assessed contemporary incidence rates and trends of primary urethral cancer.METHODS: We identified urethral cancer patients within Surveillance, Epidemiology and End Results registry (SEER, 2004-2016). Age-standardized incidence rates per 1,000,000 (ASR) were calculated. Log linear regression analyses were used to compute average annual percent change (AAPC).RESULTS: From 2004 to 2016, 1907 patients with urethral cancer were diagnosed (ASR 1.69; AAPC: -0.98%, p = 0.3). ASR rates were higher in males than in females (2.70 vs. 0.55), respectively and did not change over the time (both p = 0.3). Highest incidence rates were recorded in respectively ≥75 (0.77), 55-74 (0.71) and ≤54 (0.19) years of age categories, in that order. African Americans exhibited highest incidence rate (3.33) followed by Caucasians (1.72), other race groups (1.57) and Hispanics (1.57), in that order. A significant decrease occurred over time in Hispanics, but not in other race groups. In African Americans, male and female sex-stratified incidence rates were higher than in any other race group. Urothelial histological subtype exhibited highest incidence rate (0.92), followed by squamous cell carcinoma (0.41), adenocarcinoma (0.29) and other histologies (0.20). In stage stratified analyses, T1N0M0 stage exhibited highest incidence rate. However, it decreased over time (-3.00%, p = 0.02) in favor of T1-4N1-2M0 stage (+ 2.11%, p = 0.02).CONCLUSION: Urethral cancer is rare. Its incidence rates are highest in males, elderly patients, African Americans and in urothelial histological subtype. Most urethral cancer cases are T1N0M0, but over time, the incidence of T1N0M0 decreased in favor of T1-4N1-2M0.
AB - PURPOSE: We assessed contemporary incidence rates and trends of primary urethral cancer.METHODS: We identified urethral cancer patients within Surveillance, Epidemiology and End Results registry (SEER, 2004-2016). Age-standardized incidence rates per 1,000,000 (ASR) were calculated. Log linear regression analyses were used to compute average annual percent change (AAPC).RESULTS: From 2004 to 2016, 1907 patients with urethral cancer were diagnosed (ASR 1.69; AAPC: -0.98%, p = 0.3). ASR rates were higher in males than in females (2.70 vs. 0.55), respectively and did not change over the time (both p = 0.3). Highest incidence rates were recorded in respectively ≥75 (0.77), 55-74 (0.71) and ≤54 (0.19) years of age categories, in that order. African Americans exhibited highest incidence rate (3.33) followed by Caucasians (1.72), other race groups (1.57) and Hispanics (1.57), in that order. A significant decrease occurred over time in Hispanics, but not in other race groups. In African Americans, male and female sex-stratified incidence rates were higher than in any other race group. Urothelial histological subtype exhibited highest incidence rate (0.92), followed by squamous cell carcinoma (0.41), adenocarcinoma (0.29) and other histologies (0.20). In stage stratified analyses, T1N0M0 stage exhibited highest incidence rate. However, it decreased over time (-3.00%, p = 0.02) in favor of T1-4N1-2M0 stage (+ 2.11%, p = 0.02).CONCLUSION: Urethral cancer is rare. Its incidence rates are highest in males, elderly patients, African Americans and in urothelial histological subtype. Most urethral cancer cases are T1N0M0, but over time, the incidence of T1N0M0 decreased in favor of T1-4N1-2M0.
KW - Adenocarcinoma/diagnosis
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Carcinoma, Squamous Cell/diagnosis
KW - Female
KW - Humans
KW - Incidence
KW - Male
KW - Middle Aged
KW - Neoplasm Grading
KW - SEER Program/trends
KW - Sex Factors
KW - Urethral Neoplasms/diagnosis
U2 - 10.1007/s10552-021-01416-2
DO - 10.1007/s10552-021-01416-2
M3 - SCORING: Journal article
C2 - 33751293
VL - 32
SP - 627
EP - 634
JO - CANCER CAUSE CONTROL
JF - CANCER CAUSE CONTROL
SN - 0957-5243
IS - 6
ER -
