Incidence of major adverse cardiac events following non-cardiac surgery

Lorraine Sazgary; Christian Puelacher; Giovanna Lurati Buse; Noemi Glarner; Andreas Lampart; Daniel Bolliger; Luzius Steiner; Lorenz Gürke; Thomas Wolff; Edin Mujagic; Stefan Schaeren; Didier Lardinois; Jacqueline Espinola; Christoph Kindler; Angelika Hammerer-Lercher; Ivo Strebel; Karin Wildi; Reka Hidvegi; Johanna Gueckel; Christina Hollenstein; Tobias Breidthardt; Katharina Rentsch; Andreas Buser; Danielle M Gualandro; Christian Mueller; BASEL-PMI Investigators

doi:10.1093/ehjacc/zuaa008

Incidence of major adverse cardiac events following non-cardiac surgery

Standard

Incidence of major adverse cardiac events following non-cardiac surgery. / Sazgary, Lorraine; Puelacher, Christian; Lurati Buse, Giovanna; Glarner, Noemi; Lampart, Andreas; Bolliger, Daniel; Steiner, Luzius; Gürke, Lorenz; Wolff, Thomas; Mujagic, Edin; Schaeren, Stefan; Lardinois, Didier; Espinola, Jacqueline; Kindler, Christoph; Hammerer-Lercher, Angelika; Strebel, Ivo; Wildi, Karin; Hidvegi, Reka; Gueckel, Johanna; Hollenstein, Christina; Breidthardt, Tobias; Rentsch, Katharina; Buser, Andreas; Gualandro, Danielle M; Mueller, Christian; BASEL-PMI Investigators.

in: EUR HEART J-ACUTE CA, Jahrgang 10, Nr. 5, 14.10.2020, S. 550–558.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sazgary, L, Puelacher, C, Lurati Buse, G, Glarner, N, Lampart, A, Bolliger, D, Steiner, L, Gürke, L, Wolff, T, Mujagic, E, Schaeren, S, Lardinois, D, Espinola, J, Kindler, C, Hammerer-Lercher, A, Strebel, I, Wildi, K, Hidvegi, R, Gueckel, J, Hollenstein, C, Breidthardt, T, Rentsch, K, Buser, A, Gualandro, DM, Mueller, C & BASEL-PMI Investigators 2020, 'Incidence of major adverse cardiac events following non-cardiac surgery', EUR HEART J-ACUTE CA, Jg. 10, Nr. 5, S. 550–558. https://doi.org/10.1093/ehjacc/zuaa008

APA

Sazgary, L., Puelacher, C., Lurati Buse, G., Glarner, N., Lampart, A., Bolliger, D., Steiner, L., Gürke, L., Wolff, T., Mujagic, E., Schaeren, S., Lardinois, D., Espinola, J., Kindler, C., Hammerer-Lercher, A., Strebel, I., Wildi, K., Hidvegi, R., Gueckel, J., ... BASEL-PMI Investigators (2020). Incidence of major adverse cardiac events following non-cardiac surgery. EUR HEART J-ACUTE CA, 10(5), 550–558. https://doi.org/10.1093/ehjacc/zuaa008

Vancouver

Sazgary L, Puelacher C, Lurati Buse G, Glarner N, Lampart A, Bolliger D et al. Incidence of major adverse cardiac events following non-cardiac surgery. EUR HEART J-ACUTE CA. 2020 Okt 14;10(5):550–558. https://doi.org/10.1093/ehjacc/zuaa008

Bibtex

@article{909c9f9fba4741bfac9f271bb98d5b8f,

title = "Incidence of major adverse cardiac events following non-cardiac surgery",

abstract = "AIMS: Major adverse cardiac events (MACE) triggered by non-cardiac surgery are prognostically important perioperative complications. However, due to often asymptomatic presentation, the incidence and timing of postoperative MACE are incompletely understood.METHODS AND RESULTS: We conducted a prospective observational study implementing a perioperative screening for postoperative MACE [cardiovascular death (CVD), acute heart failure (AHF), haemodynamically relevant arrhythmias, spontaneous myocardial infarction (MI), and perioperative myocardial infarction/injury (PMI)] in patients at increased cardiovascular risk (≥65 years OR ≥45 years with history of cardiovascular disease) undergoing non-cardiac surgery at a tertiary hospital. All patients received serial measurements of cardiac troponin to detect asymptomatic MACE. Among 2265 patients (mean age 73 years, 43.4% women), the incidence of MACE was 15.2% within 30 days, and 20.6% within 365 days. CVD occurred in 1.2% [95% confidence interval (CI) 0.9-1.8] and in 3.7% (95% CI 3.0-4.5), haemodynamically relevant arrhythmias in 1.2% (95% CI 0.9-1.8) and in 2.1% (95% CI 1.6-2.8), AHF in 1.6% (95% CI 1.2-2.2) and in 4.2% (95% CI 3.4-5.1), spontaneous MI in 0.5% (95% CI 0.3-0.9) and in 1.6% (95% CI 1.2-2.2), and PMI in 13.2% (95% CI 11.9-14.7) and in 14.8% (95% CI 13.4-16.4) within 30 days and within 365 days, respectively. The MACE-incidence was increased above presumed baseline rate until Day 135 (95% CI 104-163), indicating a vulnerable period of 3-5 months.CONCLUSION: One out of five high-risk patients undergoing non-cardiac surgery will develop one or more MACE within 365 days. The risk for MACE remains increased for about 5 months after non-cardiac surgery.TRIAL REGISTRATION: https://www.clinicaltrials.gov. Unique identifier: NCT02573532.",

author = "Lorraine Sazgary and Christian Puelacher and {Lurati Buse}, Giovanna and Noemi Glarner and Andreas Lampart and Daniel Bolliger and Luzius Steiner and Lorenz G{\"u}rke and Thomas Wolff and Edin Mujagic and Stefan Schaeren and Didier Lardinois and Jacqueline Espinola and Christoph Kindler and Angelika Hammerer-Lercher and Ivo Strebel and Karin Wildi and Reka Hidvegi and Johanna Gueckel and Christina Hollenstein and Tobias Breidthardt and Katharina Rentsch and Andreas Buser and Gualandro, {Danielle M} and Christian Mueller and {BASEL-PMI Investigators} and Raphael Twerenbold",

year = "2020",

month = oct,

day = "14",

doi = "10.1093/ehjacc/zuaa008",

language = "English",

volume = "10",

pages = "550–558",

journal = "EUR HEART J-ACUTE CA",

issn = "2048-8726",

publisher = "SAGE Publications",

number = "5",

}

RIS

TY - JOUR

T1 - Incidence of major adverse cardiac events following non-cardiac surgery

AU - Sazgary, Lorraine

AU - Puelacher, Christian

AU - Lurati Buse, Giovanna

AU - Glarner, Noemi

AU - Lampart, Andreas

AU - Bolliger, Daniel

AU - Steiner, Luzius

AU - Gürke, Lorenz

AU - Wolff, Thomas

AU - Mujagic, Edin

AU - Schaeren, Stefan

AU - Lardinois, Didier

AU - Espinola, Jacqueline

AU - Kindler, Christoph

AU - Hammerer-Lercher, Angelika

AU - Strebel, Ivo

AU - Wildi, Karin

AU - Hidvegi, Reka

AU - Gueckel, Johanna

AU - Hollenstein, Christina

AU - Breidthardt, Tobias

AU - Rentsch, Katharina

AU - Buser, Andreas

AU - Gualandro, Danielle M

AU - Mueller, Christian

AU - BASEL-PMI Investigators

AU - Twerenbold, Raphael

PY - 2020/10/14

Y1 - 2020/10/14

N2 - AIMS: Major adverse cardiac events (MACE) triggered by non-cardiac surgery are prognostically important perioperative complications. However, due to often asymptomatic presentation, the incidence and timing of postoperative MACE are incompletely understood.METHODS AND RESULTS: We conducted a prospective observational study implementing a perioperative screening for postoperative MACE [cardiovascular death (CVD), acute heart failure (AHF), haemodynamically relevant arrhythmias, spontaneous myocardial infarction (MI), and perioperative myocardial infarction/injury (PMI)] in patients at increased cardiovascular risk (≥65 years OR ≥45 years with history of cardiovascular disease) undergoing non-cardiac surgery at a tertiary hospital. All patients received serial measurements of cardiac troponin to detect asymptomatic MACE. Among 2265 patients (mean age 73 years, 43.4% women), the incidence of MACE was 15.2% within 30 days, and 20.6% within 365 days. CVD occurred in 1.2% [95% confidence interval (CI) 0.9-1.8] and in 3.7% (95% CI 3.0-4.5), haemodynamically relevant arrhythmias in 1.2% (95% CI 0.9-1.8) and in 2.1% (95% CI 1.6-2.8), AHF in 1.6% (95% CI 1.2-2.2) and in 4.2% (95% CI 3.4-5.1), spontaneous MI in 0.5% (95% CI 0.3-0.9) and in 1.6% (95% CI 1.2-2.2), and PMI in 13.2% (95% CI 11.9-14.7) and in 14.8% (95% CI 13.4-16.4) within 30 days and within 365 days, respectively. The MACE-incidence was increased above presumed baseline rate until Day 135 (95% CI 104-163), indicating a vulnerable period of 3-5 months.CONCLUSION: One out of five high-risk patients undergoing non-cardiac surgery will develop one or more MACE within 365 days. The risk for MACE remains increased for about 5 months after non-cardiac surgery.TRIAL REGISTRATION: https://www.clinicaltrials.gov. Unique identifier: NCT02573532.

AB - AIMS: Major adverse cardiac events (MACE) triggered by non-cardiac surgery are prognostically important perioperative complications. However, due to often asymptomatic presentation, the incidence and timing of postoperative MACE are incompletely understood.METHODS AND RESULTS: We conducted a prospective observational study implementing a perioperative screening for postoperative MACE [cardiovascular death (CVD), acute heart failure (AHF), haemodynamically relevant arrhythmias, spontaneous myocardial infarction (MI), and perioperative myocardial infarction/injury (PMI)] in patients at increased cardiovascular risk (≥65 years OR ≥45 years with history of cardiovascular disease) undergoing non-cardiac surgery at a tertiary hospital. All patients received serial measurements of cardiac troponin to detect asymptomatic MACE. Among 2265 patients (mean age 73 years, 43.4% women), the incidence of MACE was 15.2% within 30 days, and 20.6% within 365 days. CVD occurred in 1.2% [95% confidence interval (CI) 0.9-1.8] and in 3.7% (95% CI 3.0-4.5), haemodynamically relevant arrhythmias in 1.2% (95% CI 0.9-1.8) and in 2.1% (95% CI 1.6-2.8), AHF in 1.6% (95% CI 1.2-2.2) and in 4.2% (95% CI 3.4-5.1), spontaneous MI in 0.5% (95% CI 0.3-0.9) and in 1.6% (95% CI 1.2-2.2), and PMI in 13.2% (95% CI 11.9-14.7) and in 14.8% (95% CI 13.4-16.4) within 30 days and within 365 days, respectively. The MACE-incidence was increased above presumed baseline rate until Day 135 (95% CI 104-163), indicating a vulnerable period of 3-5 months.CONCLUSION: One out of five high-risk patients undergoing non-cardiac surgery will develop one or more MACE within 365 days. The risk for MACE remains increased for about 5 months after non-cardiac surgery.TRIAL REGISTRATION: https://www.clinicaltrials.gov. Unique identifier: NCT02573532.

U2 - 10.1093/ehjacc/zuaa008

DO - 10.1093/ehjacc/zuaa008

M3 - SCORING: Journal article

C2 - 33620378

VL - 10

SP - 550

EP - 558

JO - EUR HEART J-ACUTE CA

JF - EUR HEART J-ACUTE CA

SN - 2048-8726

IS - 5

ER -