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Incidence and outcomes of perioperative myocardial infarction/injury diagnosed by high-sensitivity cardiac troponin I

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Incidence and outcomes of perioperative myocardial infarction/injury diagnosed by high-sensitivity cardiac troponin I. / Gualandro, Danielle M; Puelacher, Christian; Lurati Buse, Giovanna; Glarner, Noemi; Cardozo, Francisco A; Vogt, Ronja; Hidvegi, Reka; Strunz, Celia; Bolliger, Daniel; Gueckel, Johanna; Yu, Pai C; Liffert, Marcel; Arslani, Ketina; Prepoudis, Alexandra; Calderaro, Daniela; Hammerer-Lercher, Angelika; Lampart, Andreas; Steiner, Luzius A; Schären, Stefan; Kindler, Christoph; Guerke, Lorenz; Osswald, Stefan; Devereaux, P J; Caramelli, Bruno; Mueller, Christian; BASEL-PMI Investigators.

in: CLIN RES CARDIOL, Jahrgang 110, Nr. 9, 09.2021, S. 1450-1463.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gualandro, DM, Puelacher, C, Lurati Buse, G, Glarner, N, Cardozo, FA, Vogt, R, Hidvegi, R, Strunz, C, Bolliger, D, Gueckel, J, Yu, PC, Liffert, M, Arslani, K, Prepoudis, A, Calderaro, D, Hammerer-Lercher, A, Lampart, A, Steiner, LA, Schären, S, Kindler, C, Guerke, L, Osswald, S, Devereaux, PJ, Caramelli, B, Mueller, C & BASEL-PMI Investigators 2021, 'Incidence and outcomes of perioperative myocardial infarction/injury diagnosed by high-sensitivity cardiac troponin I', CLIN RES CARDIOL, Jg. 110, Nr. 9, S. 1450-1463. https://doi.org/10.1007/s00392-021-01827-w

APA

Gualandro, D. M., Puelacher, C., Lurati Buse, G., Glarner, N., Cardozo, F. A., Vogt, R., Hidvegi, R., Strunz, C., Bolliger, D., Gueckel, J., Yu, P. C., Liffert, M., Arslani, K., Prepoudis, A., Calderaro, D., Hammerer-Lercher, A., Lampart, A., Steiner, L. A., Schären, S., ... BASEL-PMI Investigators (2021). Incidence and outcomes of perioperative myocardial infarction/injury diagnosed by high-sensitivity cardiac troponin I. CLIN RES CARDIOL, 110(9), 1450-1463. https://doi.org/10.1007/s00392-021-01827-w

Vancouver

Gualandro DM, Puelacher C, Lurati Buse G, Glarner N, Cardozo FA, Vogt R et al. Incidence and outcomes of perioperative myocardial infarction/injury diagnosed by high-sensitivity cardiac troponin I. CLIN RES CARDIOL. 2021 Sep;110(9):1450-1463. https://doi.org/10.1007/s00392-021-01827-w

Bibtex

@article{dce16974dff74d09aa4312d63460d70c,
title = "Incidence and outcomes of perioperative myocardial infarction/injury diagnosed by high-sensitivity cardiac troponin I",
abstract = "BACKGROUND: Perioperative myocardial infarction/injury (PMI) diagnosed by high-sensitivity troponin (hs-cTn) T is frequent and a prognostically important complication of non-cardiac surgery. We aimed to evaluate the incidence and outcome of PMI diagnosed using hs-cTnI, and compare it to PMI diagnosed using hs-cTnT.METHODS: We prospectively included 2455 patients at high cardiovascular risk undergoing 3111 non-cardiac surgeries, for whom hs-cTnI and hs-cTnT concentrations were measured before surgery and on postoperative days 1 and 2. PMI was defined as a composite of perioperative myocardial infarction (PMIInfarct) and perioperative myocardial injury (PMIInjury), according to the Fourth Universal Definition of Myocardial Infarction. All-cause mortality was the primary endpoint.RESULTS: Using hs-cTnI, the incidence of overall PMI was 9% (95% confidence interval [CI] 8-10%), including PMIInfarct 2.6% (95% CI 2.0-3.2) and PMIInjury 6.1% (95% CI 5.3-6.9%), which was lower versus using hs-cTnT: overall PMI 15% (95% CI 14-16%), PMIInfarct 3.7% (95% CI 3.0-4.4) and PMIInjury 11.3% (95% CI 10.2-12.4%). All-cause mortality occurred in 52 (2%) patients within 30 days and 217 (9%) within 1 year. Using hs-cTnI, both PMIInfarct and PMIInjury were independent predictors of 30-day all-cause mortality (adjusted hazard ratio [aHR] 2.5 [95% CI 1.1-6.0], and aHR 2.8 [95% CI 1.4-5.5], respectively) and, 1-year all-cause mortality (aHR 2.0 [95% CI 1.2-3.3], and aHR 1.8 [95% CI 1.2-2.7], respectively). Overall, the prognostic impact of PMI diagnosed by hs-cTnI was comparable to the prognostic impact of PMI using hs-cTnT.CONCLUSIONS: Using hs-cTnI, PMI is less common versus using hs-cTnT. Using hs-cTnI, both PMIInfarct and PMIInjury remain independent predictors of 30-day and 1-year mortality.",
author = "Gualandro, {Danielle M} and Christian Puelacher and {Lurati Buse}, Giovanna and Noemi Glarner and Cardozo, {Francisco A} and Ronja Vogt and Reka Hidvegi and Celia Strunz and Daniel Bolliger and Johanna Gueckel and Yu, {Pai C} and Marcel Liffert and Ketina Arslani and Alexandra Prepoudis and Daniela Calderaro and Angelika Hammerer-Lercher and Andreas Lampart and Steiner, {Luzius A} and Stefan Sch{\"a}ren and Christoph Kindler and Lorenz Guerke and Stefan Osswald and Devereaux, {P J} and Bruno Caramelli and Christian Mueller and {BASEL-PMI Investigators} and Raphael Twerenbold",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
month = sep,
doi = "10.1007/s00392-021-01827-w",
language = "English",
volume = "110",
pages = "1450--1463",
journal = "CLIN RES CARDIOL",
issn = "1861-0684",
publisher = "D. Steinkopff-Verlag",
number = "9",

}

RIS

TY - JOUR

T1 - Incidence and outcomes of perioperative myocardial infarction/injury diagnosed by high-sensitivity cardiac troponin I

AU - Gualandro, Danielle M

AU - Puelacher, Christian

AU - Lurati Buse, Giovanna

AU - Glarner, Noemi

AU - Cardozo, Francisco A

AU - Vogt, Ronja

AU - Hidvegi, Reka

AU - Strunz, Celia

AU - Bolliger, Daniel

AU - Gueckel, Johanna

AU - Yu, Pai C

AU - Liffert, Marcel

AU - Arslani, Ketina

AU - Prepoudis, Alexandra

AU - Calderaro, Daniela

AU - Hammerer-Lercher, Angelika

AU - Lampart, Andreas

AU - Steiner, Luzius A

AU - Schären, Stefan

AU - Kindler, Christoph

AU - Guerke, Lorenz

AU - Osswald, Stefan

AU - Devereaux, P J

AU - Caramelli, Bruno

AU - Mueller, Christian

AU - BASEL-PMI Investigators

AU - Twerenbold, Raphael

N1 - © 2021. The Author(s).

PY - 2021/9

Y1 - 2021/9

N2 - BACKGROUND: Perioperative myocardial infarction/injury (PMI) diagnosed by high-sensitivity troponin (hs-cTn) T is frequent and a prognostically important complication of non-cardiac surgery. We aimed to evaluate the incidence and outcome of PMI diagnosed using hs-cTnI, and compare it to PMI diagnosed using hs-cTnT.METHODS: We prospectively included 2455 patients at high cardiovascular risk undergoing 3111 non-cardiac surgeries, for whom hs-cTnI and hs-cTnT concentrations were measured before surgery and on postoperative days 1 and 2. PMI was defined as a composite of perioperative myocardial infarction (PMIInfarct) and perioperative myocardial injury (PMIInjury), according to the Fourth Universal Definition of Myocardial Infarction. All-cause mortality was the primary endpoint.RESULTS: Using hs-cTnI, the incidence of overall PMI was 9% (95% confidence interval [CI] 8-10%), including PMIInfarct 2.6% (95% CI 2.0-3.2) and PMIInjury 6.1% (95% CI 5.3-6.9%), which was lower versus using hs-cTnT: overall PMI 15% (95% CI 14-16%), PMIInfarct 3.7% (95% CI 3.0-4.4) and PMIInjury 11.3% (95% CI 10.2-12.4%). All-cause mortality occurred in 52 (2%) patients within 30 days and 217 (9%) within 1 year. Using hs-cTnI, both PMIInfarct and PMIInjury were independent predictors of 30-day all-cause mortality (adjusted hazard ratio [aHR] 2.5 [95% CI 1.1-6.0], and aHR 2.8 [95% CI 1.4-5.5], respectively) and, 1-year all-cause mortality (aHR 2.0 [95% CI 1.2-3.3], and aHR 1.8 [95% CI 1.2-2.7], respectively). Overall, the prognostic impact of PMI diagnosed by hs-cTnI was comparable to the prognostic impact of PMI using hs-cTnT.CONCLUSIONS: Using hs-cTnI, PMI is less common versus using hs-cTnT. Using hs-cTnI, both PMIInfarct and PMIInjury remain independent predictors of 30-day and 1-year mortality.

AB - BACKGROUND: Perioperative myocardial infarction/injury (PMI) diagnosed by high-sensitivity troponin (hs-cTn) T is frequent and a prognostically important complication of non-cardiac surgery. We aimed to evaluate the incidence and outcome of PMI diagnosed using hs-cTnI, and compare it to PMI diagnosed using hs-cTnT.METHODS: We prospectively included 2455 patients at high cardiovascular risk undergoing 3111 non-cardiac surgeries, for whom hs-cTnI and hs-cTnT concentrations were measured before surgery and on postoperative days 1 and 2. PMI was defined as a composite of perioperative myocardial infarction (PMIInfarct) and perioperative myocardial injury (PMIInjury), according to the Fourth Universal Definition of Myocardial Infarction. All-cause mortality was the primary endpoint.RESULTS: Using hs-cTnI, the incidence of overall PMI was 9% (95% confidence interval [CI] 8-10%), including PMIInfarct 2.6% (95% CI 2.0-3.2) and PMIInjury 6.1% (95% CI 5.3-6.9%), which was lower versus using hs-cTnT: overall PMI 15% (95% CI 14-16%), PMIInfarct 3.7% (95% CI 3.0-4.4) and PMIInjury 11.3% (95% CI 10.2-12.4%). All-cause mortality occurred in 52 (2%) patients within 30 days and 217 (9%) within 1 year. Using hs-cTnI, both PMIInfarct and PMIInjury were independent predictors of 30-day all-cause mortality (adjusted hazard ratio [aHR] 2.5 [95% CI 1.1-6.0], and aHR 2.8 [95% CI 1.4-5.5], respectively) and, 1-year all-cause mortality (aHR 2.0 [95% CI 1.2-3.3], and aHR 1.8 [95% CI 1.2-2.7], respectively). Overall, the prognostic impact of PMI diagnosed by hs-cTnI was comparable to the prognostic impact of PMI using hs-cTnT.CONCLUSIONS: Using hs-cTnI, PMI is less common versus using hs-cTnT. Using hs-cTnI, both PMIInfarct and PMIInjury remain independent predictors of 30-day and 1-year mortality.

U2 - 10.1007/s00392-021-01827-w

DO - 10.1007/s00392-021-01827-w

M3 - SCORING: Journal article

C2 - 33768367

VL - 110

SP - 1450

EP - 1463

JO - CLIN RES CARDIOL

JF - CLIN RES CARDIOL

SN - 1861-0684

IS - 9

ER -