Improvement of schizophrenic patients' subjective well-being under atypical antipsychotic drugs.
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Improvement of schizophrenic patients' subjective well-being under atypical antipsychotic drugs. / Naber, Dieter; Moritz, Steffen; Lambert, Martin; Pajonk, F G; Holzbach, R; Mass, R; Andresen, B; Rajonk, F.
in: SCHIZOPHR RES, Jahrgang 50, Nr. 1-2, 1-2, 2001, S. 79-88.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Improvement of schizophrenic patients' subjective well-being under atypical antipsychotic drugs.
AU - Naber, Dieter
AU - Moritz, Steffen
AU - Lambert, Martin
AU - Pajonk, F G
AU - Holzbach, R
AU - Mass, R
AU - Andresen, B
AU - Rajonk, F
PY - 2001
Y1 - 2001
N2 - Recent research indicates that subjective well-being is a major determinant of medication compliance in schizophrenia. However, it is yet unresolved whether atypical neuroleptics differ regarding subjective side-effects. A self-report instrument has been constructed to evaluate 'subjective well-being under neuroleptics' (SWN). The primary aims of the present study were to develop a short form of the SWN and to investigate the extent to which the atypical antipsychotic improves the patient's subjective well-being.The short form of the SWN was constructed following an item analysis based on data from 212 schizophrenic patients medicated with either typical or atypical antipsychotics. The short form of the SWN showed sufficient internal consistency and good construct validity. The SWN was only moderately correlated with positive and negative syndrome scale (PANSS) scores or changes in psychopathology (r=-0.20 to -0.37). SWN-ratings in patients receiving olanzapine were superior compared to those of patients medicated with either clozapine or risperidone on three of five domains of well-being. Clozapine reduced global psychiatric symptoms significantly more than risperidone. It is concluded that the assessment of subjective well-being under antipsychotic treatment provides an independent outcome measure which is relevant to compliance.
AB - Recent research indicates that subjective well-being is a major determinant of medication compliance in schizophrenia. However, it is yet unresolved whether atypical neuroleptics differ regarding subjective side-effects. A self-report instrument has been constructed to evaluate 'subjective well-being under neuroleptics' (SWN). The primary aims of the present study were to develop a short form of the SWN and to investigate the extent to which the atypical antipsychotic improves the patient's subjective well-being.The short form of the SWN was constructed following an item analysis based on data from 212 schizophrenic patients medicated with either typical or atypical antipsychotics. The short form of the SWN showed sufficient internal consistency and good construct validity. The SWN was only moderately correlated with positive and negative syndrome scale (PANSS) scores or changes in psychopathology (r=-0.20 to -0.37). SWN-ratings in patients receiving olanzapine were superior compared to those of patients medicated with either clozapine or risperidone on three of five domains of well-being. Clozapine reduced global psychiatric symptoms significantly more than risperidone. It is concluded that the assessment of subjective well-being under antipsychotic treatment provides an independent outcome measure which is relevant to compliance.
M3 - SCORING: Zeitschriftenaufsatz
VL - 50
SP - 79
EP - 88
JO - SCHIZOPHR RES
JF - SCHIZOPHR RES
SN - 0920-9964
IS - 1-2
M1 - 1-2
ER -
