[Improved prognosis in Wilms' tumor due to adjuvant combination drug therapy]
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[Improved prognosis in Wilms' tumor due to adjuvant combination drug therapy]. / Haas, R J; Helmig, F J; Hausner, H; Eife, R; Devens, K; Janka-Schaub, Gritta; Helmig, M; Lampert, F.
in: ONKOLOGIE, Jahrgang 5, Nr. 2, 2, 1982, S. 60-66.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - [Improved prognosis in Wilms' tumor due to adjuvant combination drug therapy]
AU - Haas, R J
AU - Helmig, F J
AU - Hausner, H
AU - Eife, R
AU - Devens, K
AU - Janka-Schaub, Gritta
AU - Helmig, M
AU - Lampert, F
PY - 1982
Y1 - 1982
N2 - 78 children with Wilms' tumor stage I--IV diagnosed since 1960 are presented. There were two groups of patients: one group consisting of 35 patients which received adjuvant chemotherapy for 1 year, the other group consisting of 43 patients which received no chemotherapy. Surgical excision and irradiation was identical in both groups. The prognosis was greatly improved by adjuvant chemotherapy: 4-year survival rates increased from 25 to 69%. Late side effects from radiation and chemotherapy were noted: 15/78 patients suffered from scoliosis and all patients treated by chemotherapy had a decreased lymphotoxin activity over years. The following factors appear to be related to prognosis: the extent of disease in patients determined by better techniques, histopathology of the tumor, and the nature of treatment.
AB - 78 children with Wilms' tumor stage I--IV diagnosed since 1960 are presented. There were two groups of patients: one group consisting of 35 patients which received adjuvant chemotherapy for 1 year, the other group consisting of 43 patients which received no chemotherapy. Surgical excision and irradiation was identical in both groups. The prognosis was greatly improved by adjuvant chemotherapy: 4-year survival rates increased from 25 to 69%. Late side effects from radiation and chemotherapy were noted: 15/78 patients suffered from scoliosis and all patients treated by chemotherapy had a decreased lymphotoxin activity over years. The following factors appear to be related to prognosis: the extent of disease in patients determined by better techniques, histopathology of the tumor, and the nature of treatment.
M3 - SCORING: Zeitschriftenaufsatz
VL - 5
SP - 60
EP - 66
JO - ONKOLOGIE
JF - ONKOLOGIE
SN - 0378-584X
IS - 2
M1 - 2
ER -