Implications of Sex Differences in Immunity for SARS-CoV-2 Pathogenesis and Design of Therapeutic Interventions

Madeleine J Bunders; Marcus Altfeld

doi:10.1016/j.immuni.2020.08.003

Implications of Sex Differences in Immunity for SARS-CoV-2 Pathogenesis and Design of Therapeutic Interventions

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Implications of Sex Differences in Immunity for SARS-CoV-2 Pathogenesis and Design of Therapeutic Interventions. / Bunders, Madeleine J ; Altfeld, Marcus.

in: IMMUNITY, Jahrgang 53, Nr. 3, 15.09.2020, S. 487-495.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Bunders, MJ & Altfeld, M 2020, 'Implications of Sex Differences in Immunity for SARS-CoV-2 Pathogenesis and Design of Therapeutic Interventions', IMMUNITY, Jg. 53, Nr. 3, S. 487-495. https://doi.org/10.1016/j.immuni.2020.08.003

APA

Bunders, M. J., & Altfeld, M. (2020). Implications of Sex Differences in Immunity for SARS-CoV-2 Pathogenesis and Design of Therapeutic Interventions. IMMUNITY, 53(3), 487-495. https://doi.org/10.1016/j.immuni.2020.08.003

Vancouver

Bunders MJ , Altfeld M. Implications of Sex Differences in Immunity for SARS-CoV-2 Pathogenesis and Design of Therapeutic Interventions. IMMUNITY. 2020 Sep 15;53(3):487-495. https://doi.org/10.1016/j.immuni.2020.08.003

Bibtex

@article{f25fc7745692498480d92bb4c6c10167,

title = "Implications of Sex Differences in Immunity for SARS-CoV-2 Pathogenesis and Design of Therapeutic Interventions",

abstract = "Men present more frequently with severe manifestations of coronavirus disease 2019 (COVID-19) and are at higher risk for death. The underlying mechanisms for these differences between female and male individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are insufficiently understood. However, studies from other viral infections have shown that females can mount stronger immune responses against viruses than males. Emerging knowledge on the basic biological pathways that underlie differences in immune responses between women and men needs to be incorporated into research efforts on SARS-CoV-2 pathogenesis and pathology to identify targets for therapeutic interventions aimed at enhancing antiviral immune function and lung airway resilience while reducing pathogenic inflammation in COVID-19.",

author = "Bunders, {Madeleine J} and Marcus Altfeld",

year = "2020",

month = sep,

day = "15",

doi = "10.1016/j.immuni.2020.08.003",

language = "English",

volume = "53",

pages = "487--495",

journal = "IMMUNITY",

issn = "1074-7613",

publisher = "Cell Press",

number = "3",

}

RIS

TY - JOUR

T1 - Implications of Sex Differences in Immunity for SARS-CoV-2 Pathogenesis and Design of Therapeutic Interventions

AU - Bunders, Madeleine J

AU - Altfeld, Marcus

PY - 2020/9/15

Y1 - 2020/9/15

N2 - Men present more frequently with severe manifestations of coronavirus disease 2019 (COVID-19) and are at higher risk for death. The underlying mechanisms for these differences between female and male individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are insufficiently understood. However, studies from other viral infections have shown that females can mount stronger immune responses against viruses than males. Emerging knowledge on the basic biological pathways that underlie differences in immune responses between women and men needs to be incorporated into research efforts on SARS-CoV-2 pathogenesis and pathology to identify targets for therapeutic interventions aimed at enhancing antiviral immune function and lung airway resilience while reducing pathogenic inflammation in COVID-19.

AB - Men present more frequently with severe manifestations of coronavirus disease 2019 (COVID-19) and are at higher risk for death. The underlying mechanisms for these differences between female and male individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are insufficiently understood. However, studies from other viral infections have shown that females can mount stronger immune responses against viruses than males. Emerging knowledge on the basic biological pathways that underlie differences in immune responses between women and men needs to be incorporated into research efforts on SARS-CoV-2 pathogenesis and pathology to identify targets for therapeutic interventions aimed at enhancing antiviral immune function and lung airway resilience while reducing pathogenic inflammation in COVID-19.

U2 - 10.1016/j.immuni.2020.08.003

DO - 10.1016/j.immuni.2020.08.003

M3 - SCORING: Review article

C2 - 32853545

VL - 53

SP - 487

EP - 495

JO - IMMUNITY

JF - IMMUNITY

SN - 1074-7613

IS - 3

ER -