Impairment of respiratory muscle function in pulmonary hypertension.
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Impairment of respiratory muscle function in pulmonary hypertension. / Kabitz, Hans-Joachim; Schwoerer, Anja; Bremer, Hinrich-Cordt; Sonntag, Florian; Walterspacher, Stephan; Walker, David; Schaefer, Vanessa; Ehlken, Nicola; Staehler, Gerd; Halank, Michael; Klose, Hans; Ghofrani, Hossein A; Hoeper, Marius M; Gruenig, Ekkehard; Windisch, Wolfram.
in: CLIN SCI, Jahrgang 114, Nr. 2, 2, 2008, S. 165-171.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Impairment of respiratory muscle function in pulmonary hypertension.
AU - Kabitz, Hans-Joachim
AU - Schwoerer, Anja
AU - Bremer, Hinrich-Cordt
AU - Sonntag, Florian
AU - Walterspacher, Stephan
AU - Walker, David
AU - Schaefer, Vanessa
AU - Ehlken, Nicola
AU - Staehler, Gerd
AU - Halank, Michael
AU - Klose, Hans
AU - Ghofrani, Hossein A
AU - Hoeper, Marius M
AU - Gruenig, Ekkehard
AU - Windisch, Wolfram
PY - 2008
Y1 - 2008
N2 - It has been suggested that impaired respiratory muscle function occurs in patients with PH (pulmonary hypertension); however, comprehensive investigations of respiratory muscle function, including the application of non-volitional tests, needed to verify impairment of respiratory muscle strength in patients with PH have not yet been performed. In the present study, respiratory muscle function was assessed in 31 patients with PH (20 females and 11 males; mean pulmonary artery pressure, 51+/-20 mmHg; median World Health Organization class 3.0+/-0.5; 25 patients with pulmonary arterial hypertension and six patients with chronic thromboembolic PH) and in 31 control subjects (20 females and 11 males) well-matched for gender, age and BMI (body mass index). A 6-min walking test was performed to determine exercise capacity. Volitionally assessed maximal inspiratory (7.5+/-2.1 compared with 6.2+/-2.8 kPa; P=0.04) and expiratory (13.3+/-4.2 compared with 9.9+/-3.4 kPa; P
AB - It has been suggested that impaired respiratory muscle function occurs in patients with PH (pulmonary hypertension); however, comprehensive investigations of respiratory muscle function, including the application of non-volitional tests, needed to verify impairment of respiratory muscle strength in patients with PH have not yet been performed. In the present study, respiratory muscle function was assessed in 31 patients with PH (20 females and 11 males; mean pulmonary artery pressure, 51+/-20 mmHg; median World Health Organization class 3.0+/-0.5; 25 patients with pulmonary arterial hypertension and six patients with chronic thromboembolic PH) and in 31 control subjects (20 females and 11 males) well-matched for gender, age and BMI (body mass index). A 6-min walking test was performed to determine exercise capacity. Volitionally assessed maximal inspiratory (7.5+/-2.1 compared with 6.2+/-2.8 kPa; P=0.04) and expiratory (13.3+/-4.2 compared with 9.9+/-3.4 kPa; P
M3 - SCORING: Zeitschriftenaufsatz
VL - 114
SP - 165
EP - 171
JO - CLIN SCI
JF - CLIN SCI
SN - 0143-5221
IS - 2
M1 - 2
ER -