Impairment of in vivo theta-burst long-term potentiation and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle.

Peter Jedlicka; Stephan W Schwarzacher; Raphael Winkels; Friederike Kienzler; Michael Frotscher; Clive R Bramham; Christian Schultz; Bas Orth Carlos; Thomas Deller

Impairment of in vivo theta-burst long-term potentiation and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle.

Standard

Impairment of in vivo theta-burst long-term potentiation and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle. / Jedlicka, Peter; Schwarzacher, Stephan W; Winkels, Raphael; Kienzler, Friederike; Frotscher, Michael; Bramham, Clive R; Schultz, Christian; Carlos, Bas Orth; Deller, Thomas.

in: HIPPOCAMPUS, Jahrgang 19, Nr. 2, 2, 2009, S. 130-140.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Jedlicka, P, Schwarzacher, SW, Winkels, R, Kienzler, F, Frotscher, M, Bramham, CR, Schultz, C, Carlos, BO & Deller, T 2009, 'Impairment of in vivo theta-burst long-term potentiation and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle.', HIPPOCAMPUS, Jg. 19, Nr. 2, 2, S. 130-140. <http://www.ncbi.nlm.nih.gov/pubmed/18767067?dopt=Citation>

APA

Jedlicka, P., Schwarzacher, S. W., Winkels, R., Kienzler, F., Frotscher, M., Bramham, C. R., Schultz, C., Carlos, B. O., & Deller, T. (2009). Impairment of in vivo theta-burst long-term potentiation and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle. HIPPOCAMPUS, 19(2), 130-140. [2]. http://www.ncbi.nlm.nih.gov/pubmed/18767067?dopt=Citation

Vancouver

Jedlicka P, Schwarzacher SW, Winkels R, Kienzler F, Frotscher M, Bramham CR et al. Impairment of in vivo theta-burst long-term potentiation and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle. HIPPOCAMPUS. 2009;19(2):130-140. 2.

Bibtex

@article{ced28565c201454ab93fae46920cdffc,

title = "Impairment of in vivo theta-burst long-term potentiation and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle.",

abstract = "The function of the spine apparatus in dendritic spines and the cisternal organelles in axon initial segments is little understood. The actin-associated protein, synaptopodin, is essential for the formation of these organelles which are absent in synaptopodin -/- mice. Here, we used synaptopodin -/- mice to explore the role of the spine apparatus and the cisternal organelle in synaptic plasticity and local circuit excitability in response to activation of the perforant path input to the dentate gyrus in vivo. We found impaired long-term potentiation following theta-burst stimulation, whereas tetanus-evoked LTP was unaffected. Furthermore, paired-pulse inhibition of the population spike was reduced and granule cell excitability was enhanced in mutants, hence revealing an impairment of local network inhibition. In summary, our data represent the first electrophysiological evidence that the lack of the spine apparatus and the cisternal organelle leads to a defect in long-term synaptic plasticity and alterations in local circuit control of granule cell excitability under adult in vivo conditions.",

keywords = "Animals, Male, Mice, Mice, Knockout, Neurons physiology, Action Potentials physiology, Dendritic Spines physiology, Dentate Gyrus physiology, Electric Stimulation, Excitatory Postsynaptic Potentials physiology, Fluorescent Antibody Technique, Imaging, Three-Dimensional, Long-Term Potentiation physiology, Microelectrodes, Microfilament Proteins deficiency, Models, Neurological, Neural Inhibition physiology, Organelles physiology, Perforant Pathway physiology, Synapses physiology, Animals, Male, Mice, Mice, Knockout, Neurons physiology, Action Potentials physiology, Dendritic Spines physiology, Dentate Gyrus physiology, Electric Stimulation, Excitatory Postsynaptic Potentials physiology, Fluorescent Antibody Technique, Imaging, Three-Dimensional, Long-Term Potentiation physiology, Microelectrodes, Microfilament Proteins deficiency, Models, Neurological, Neural Inhibition physiology, Organelles physiology, Perforant Pathway physiology, Synapses physiology",

author = "Peter Jedlicka and Schwarzacher, {Stephan W} and Raphael Winkels and Friederike Kienzler and Michael Frotscher and Bramham, {Clive R} and Christian Schultz and Carlos, {Bas Orth} and Thomas Deller",

year = "2009",

language = "Deutsch",

volume = "19",

pages = "130--140",

journal = "HIPPOCAMPUS",

issn = "1050-9631",

publisher = "Wiley-Liss Inc.",

number = "2",

}

RIS

TY - JOUR

T1 - Impairment of in vivo theta-burst long-term potentiation and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle.

AU - Jedlicka, Peter

AU - Schwarzacher, Stephan W

AU - Winkels, Raphael

AU - Kienzler, Friederike

AU - Frotscher, Michael

AU - Bramham, Clive R

AU - Schultz, Christian

AU - Carlos, Bas Orth

AU - Deller, Thomas

PY - 2009

Y1 - 2009

N2 - The function of the spine apparatus in dendritic spines and the cisternal organelles in axon initial segments is little understood. The actin-associated protein, synaptopodin, is essential for the formation of these organelles which are absent in synaptopodin -/- mice. Here, we used synaptopodin -/- mice to explore the role of the spine apparatus and the cisternal organelle in synaptic plasticity and local circuit excitability in response to activation of the perforant path input to the dentate gyrus in vivo. We found impaired long-term potentiation following theta-burst stimulation, whereas tetanus-evoked LTP was unaffected. Furthermore, paired-pulse inhibition of the population spike was reduced and granule cell excitability was enhanced in mutants, hence revealing an impairment of local network inhibition. In summary, our data represent the first electrophysiological evidence that the lack of the spine apparatus and the cisternal organelle leads to a defect in long-term synaptic plasticity and alterations in local circuit control of granule cell excitability under adult in vivo conditions.

AB - The function of the spine apparatus in dendritic spines and the cisternal organelles in axon initial segments is little understood. The actin-associated protein, synaptopodin, is essential for the formation of these organelles which are absent in synaptopodin -/- mice. Here, we used synaptopodin -/- mice to explore the role of the spine apparatus and the cisternal organelle in synaptic plasticity and local circuit excitability in response to activation of the perforant path input to the dentate gyrus in vivo. We found impaired long-term potentiation following theta-burst stimulation, whereas tetanus-evoked LTP was unaffected. Furthermore, paired-pulse inhibition of the population spike was reduced and granule cell excitability was enhanced in mutants, hence revealing an impairment of local network inhibition. In summary, our data represent the first electrophysiological evidence that the lack of the spine apparatus and the cisternal organelle leads to a defect in long-term synaptic plasticity and alterations in local circuit control of granule cell excitability under adult in vivo conditions.

KW - Animals

KW - Male

KW - Mice

KW - Mice, Knockout

KW - Neurons physiology

KW - Action Potentials physiology

KW - Dendritic Spines physiology

KW - Dentate Gyrus physiology

KW - Electric Stimulation

KW - Excitatory Postsynaptic Potentials physiology

KW - Fluorescent Antibody Technique

KW - Imaging, Three-Dimensional

KW - Long-Term Potentiation physiology

KW - Microelectrodes

KW - Microfilament Proteins deficiency

KW - Models, Neurological

KW - Neural Inhibition physiology

KW - Organelles physiology

KW - Perforant Pathway physiology

KW - Synapses physiology

KW - Animals

KW - Male

KW - Mice

KW - Mice, Knockout

KW - Neurons physiology

KW - Action Potentials physiology

KW - Dendritic Spines physiology

KW - Dentate Gyrus physiology

KW - Electric Stimulation

KW - Excitatory Postsynaptic Potentials physiology

KW - Fluorescent Antibody Technique

KW - Imaging, Three-Dimensional

KW - Long-Term Potentiation physiology

KW - Microelectrodes

KW - Microfilament Proteins deficiency

KW - Models, Neurological

KW - Neural Inhibition physiology

KW - Organelles physiology

KW - Perforant Pathway physiology

KW - Synapses physiology

M3 - SCORING: Zeitschriftenaufsatz

VL - 19

SP - 130

EP - 140

JO - HIPPOCAMPUS

JF - HIPPOCAMPUS

SN - 1050-9631

IS - 2

M1 - 2

ER -