Impaired working memory duration but normal learning abilities found in mice that are conditionally deficient in the close homolog of L1.
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Impaired working memory duration but normal learning abilities found in mice that are conditionally deficient in the close homolog of L1. / Kolata, Stefan; Wu, Junfang; Light, Kenneth; Schachner, Melitta; Matzel, Louis D.
in: J NEUROSCI, Jahrgang 28, Nr. 50, 50, 2008, S. 13505-13510.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Impaired working memory duration but normal learning abilities found in mice that are conditionally deficient in the close homolog of L1.
AU - Kolata, Stefan
AU - Wu, Junfang
AU - Light, Kenneth
AU - Schachner, Melitta
AU - Matzel, Louis D
PY - 2008
Y1 - 2008
N2 - In addition to its role in axon growth and neuronal migration, the close homolog of L1 (CHL1), a member of the L1 family of cell adhesion molecules, is involved in synaptic plasticity. To date, little has been done to disassociate the role of CHL1 during adulthood from its role during development. To address this issue, mice conditionally deficient in CHL1 (lacking CHL1 only after the third postnatal week) were tested relative to littermate controls as adults in five learning tasks and several tests of working memory (including duration and selective attention). CHL1-deficient mice showed no impairments in the learning tasks compared with wild-type controls. CHL1 deletion had no effect on selective attention despite its widespread impairment of working memory duration. These results suggest a role for CHL1 in the adult-brain in the short-term maintenance of information.
AB - In addition to its role in axon growth and neuronal migration, the close homolog of L1 (CHL1), a member of the L1 family of cell adhesion molecules, is involved in synaptic plasticity. To date, little has been done to disassociate the role of CHL1 during adulthood from its role during development. To address this issue, mice conditionally deficient in CHL1 (lacking CHL1 only after the third postnatal week) were tested relative to littermate controls as adults in five learning tasks and several tests of working memory (including duration and selective attention). CHL1-deficient mice showed no impairments in the learning tasks compared with wild-type controls. CHL1 deletion had no effect on selective attention despite its widespread impairment of working memory duration. These results suggest a role for CHL1 in the adult-brain in the short-term maintenance of information.
M3 - SCORING: Zeitschriftenaufsatz
VL - 28
SP - 13505
EP - 13510
JO - J NEUROSCI
JF - J NEUROSCI
SN - 0270-6474
IS - 50
M1 - 50
ER -
