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Impaired sense of smell and color discrimination in monogenic and idiopathic Parkinson's disease.

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Impaired sense of smell and color discrimination in monogenic and idiopathic Parkinson's disease. / Kertelge, Lena; Brüggemann, Norbert; Schmidt, Alexander; Tadic, Vera; Wisse, Claudia; Dankert, Sylwia; Drude, Laura; van der Vegt, Joyce; Siebner, Hartwig; Pawlack, Heike; Pramstaller, Peter P; Behrens, Maria Isabel; Ramirez, Alfredo; Reichel, Dirk; Buhmann, Carsten; Hagenah, Johann; Klein, Christine; Lohmann, Katja; Kasten, Meike.

in: MOVEMENT DISORD, Jahrgang 25, Nr. 15, 15, 2010, S. 2665-2669.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kertelge, L, Brüggemann, N, Schmidt, A, Tadic, V, Wisse, C, Dankert, S, Drude, L, van der Vegt, J, Siebner, H, Pawlack, H, Pramstaller, PP, Behrens, MI, Ramirez, A, Reichel, D, Buhmann, C, Hagenah, J, Klein, C, Lohmann, K & Kasten, M 2010, 'Impaired sense of smell and color discrimination in monogenic and idiopathic Parkinson's disease.', MOVEMENT DISORD, Jg. 25, Nr. 15, 15, S. 2665-2669. <http://www.ncbi.nlm.nih.gov/pubmed/20721915?dopt=Citation>

APA

Kertelge, L., Brüggemann, N., Schmidt, A., Tadic, V., Wisse, C., Dankert, S., Drude, L., van der Vegt, J., Siebner, H., Pawlack, H., Pramstaller, P. P., Behrens, M. I., Ramirez, A., Reichel, D., Buhmann, C., Hagenah, J., Klein, C., Lohmann, K., & Kasten, M. (2010). Impaired sense of smell and color discrimination in monogenic and idiopathic Parkinson's disease. MOVEMENT DISORD, 25(15), 2665-2669. [15]. http://www.ncbi.nlm.nih.gov/pubmed/20721915?dopt=Citation

Vancouver

Kertelge L, Brüggemann N, Schmidt A, Tadic V, Wisse C, Dankert S et al. Impaired sense of smell and color discrimination in monogenic and idiopathic Parkinson's disease. MOVEMENT DISORD. 2010;25(15):2665-2669. 15.

Bibtex

@article{a60bab0f24bc48bb8a15d2cebb13748a,
title = "Impaired sense of smell and color discrimination in monogenic and idiopathic Parkinson's disease.",
abstract = "Olfaction is typically impaired in idiopathic Parkinson's disease (IPD), but its role is uncertain in monogenic PD. Diminished color discrimination has been suggested as another early sign of dopaminergic dysfunction but not been systematically studied. Furthermore, it is unknown whether both deficits are linked. We examined 100 patients with IPD, 27 manifesting mutation carriers (MC), 20 nonmanifesting mutation carriers (NMC), and 110 controls. Participants underwent a standardized neurological examination, the University of Pennsylvania Smell Identification Test (UPSIT), the Farnsworth-Munsell (FM) color discrimination test, and mutation testing in known PD genes. The monogenic group consisted of 15 Parkin (6MC/9NMC), 17 PINK1 (10MC/7NMC), 8 LRRK2 (4MC/4NMC), 3 SNCA (MC), and 4 ATP13A2 (MC) carriers. Olfaction was most impaired in IPD (UPSIT percentiles 10.1 ± 13.5) compared with all other groups (MC 13.8 ± 11.9, NMC 19.6 ± 13.0, controls 33.8 ± 22.4). Within MC, carriers of two mutations in Parkin and PINK1 showed higher UPSIT percentiles than LRRK2 and SNCA carriers. Color discrimination was reduced in IPD (FM total error score 134.8 ± 92.7). In MC (122.4 ± 142.4), the reduction was most pronounced in LRRK2, NMC (80.0 ± 38.8) were comparable with controls (97.2 ± 61.1). UPSIT and FM scores were correlated in the control (r = -0.305; P = 0.002) and the IPD group (r = -0.303; P = 0.006) but not among mutation carriers. First, we confirmed olfaction and color discrimination to be impaired in IPD and suggest olfaction to be a premotor sign. Second, olfaction differed between carriers with one and two mutations in Parkin/PINK1-associated PD. Third, olfaction and color discrimination impairment do not necessarily evolve in parallel.",
keywords = "Humans, Male, Aged, Female, Middle Aged, Mutation, Statistics, Nonparametric, Genetic Testing, Parkinson Disease genetics, Discrimination (Psychology) physiology, Color Perception genetics, Color Vision Defects genetics, Olfaction Disorders genetics, Smell genetics, alpha-Synuclein genetics, Humans, Male, Aged, Female, Middle Aged, Mutation, Statistics, Nonparametric, Genetic Testing, Parkinson Disease genetics, Discrimination (Psychology) physiology, Color Perception genetics, Color Vision Defects genetics, Olfaction Disorders genetics, Smell genetics, alpha-Synuclein genetics",
author = "Lena Kertelge and Norbert Br{\"u}ggemann and Alexander Schmidt and Vera Tadic and Claudia Wisse and Sylwia Dankert and Laura Drude and {van der Vegt}, Joyce and Hartwig Siebner and Heike Pawlack and Pramstaller, {Peter P} and Behrens, {Maria Isabel} and Alfredo Ramirez and Dirk Reichel and Carsten Buhmann and Johann Hagenah and Christine Klein and Katja Lohmann and Meike Kasten",
year = "2010",
language = "English",
volume = "25",
pages = "2665--2669",
journal = "MOVEMENT DISORD",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "15",

}

RIS

TY - JOUR

T1 - Impaired sense of smell and color discrimination in monogenic and idiopathic Parkinson's disease.

AU - Kertelge, Lena

AU - Brüggemann, Norbert

AU - Schmidt, Alexander

AU - Tadic, Vera

AU - Wisse, Claudia

AU - Dankert, Sylwia

AU - Drude, Laura

AU - van der Vegt, Joyce

AU - Siebner, Hartwig

AU - Pawlack, Heike

AU - Pramstaller, Peter P

AU - Behrens, Maria Isabel

AU - Ramirez, Alfredo

AU - Reichel, Dirk

AU - Buhmann, Carsten

AU - Hagenah, Johann

AU - Klein, Christine

AU - Lohmann, Katja

AU - Kasten, Meike

PY - 2010

Y1 - 2010

N2 - Olfaction is typically impaired in idiopathic Parkinson's disease (IPD), but its role is uncertain in monogenic PD. Diminished color discrimination has been suggested as another early sign of dopaminergic dysfunction but not been systematically studied. Furthermore, it is unknown whether both deficits are linked. We examined 100 patients with IPD, 27 manifesting mutation carriers (MC), 20 nonmanifesting mutation carriers (NMC), and 110 controls. Participants underwent a standardized neurological examination, the University of Pennsylvania Smell Identification Test (UPSIT), the Farnsworth-Munsell (FM) color discrimination test, and mutation testing in known PD genes. The monogenic group consisted of 15 Parkin (6MC/9NMC), 17 PINK1 (10MC/7NMC), 8 LRRK2 (4MC/4NMC), 3 SNCA (MC), and 4 ATP13A2 (MC) carriers. Olfaction was most impaired in IPD (UPSIT percentiles 10.1 ± 13.5) compared with all other groups (MC 13.8 ± 11.9, NMC 19.6 ± 13.0, controls 33.8 ± 22.4). Within MC, carriers of two mutations in Parkin and PINK1 showed higher UPSIT percentiles than LRRK2 and SNCA carriers. Color discrimination was reduced in IPD (FM total error score 134.8 ± 92.7). In MC (122.4 ± 142.4), the reduction was most pronounced in LRRK2, NMC (80.0 ± 38.8) were comparable with controls (97.2 ± 61.1). UPSIT and FM scores were correlated in the control (r = -0.305; P = 0.002) and the IPD group (r = -0.303; P = 0.006) but not among mutation carriers. First, we confirmed olfaction and color discrimination to be impaired in IPD and suggest olfaction to be a premotor sign. Second, olfaction differed between carriers with one and two mutations in Parkin/PINK1-associated PD. Third, olfaction and color discrimination impairment do not necessarily evolve in parallel.

AB - Olfaction is typically impaired in idiopathic Parkinson's disease (IPD), but its role is uncertain in monogenic PD. Diminished color discrimination has been suggested as another early sign of dopaminergic dysfunction but not been systematically studied. Furthermore, it is unknown whether both deficits are linked. We examined 100 patients with IPD, 27 manifesting mutation carriers (MC), 20 nonmanifesting mutation carriers (NMC), and 110 controls. Participants underwent a standardized neurological examination, the University of Pennsylvania Smell Identification Test (UPSIT), the Farnsworth-Munsell (FM) color discrimination test, and mutation testing in known PD genes. The monogenic group consisted of 15 Parkin (6MC/9NMC), 17 PINK1 (10MC/7NMC), 8 LRRK2 (4MC/4NMC), 3 SNCA (MC), and 4 ATP13A2 (MC) carriers. Olfaction was most impaired in IPD (UPSIT percentiles 10.1 ± 13.5) compared with all other groups (MC 13.8 ± 11.9, NMC 19.6 ± 13.0, controls 33.8 ± 22.4). Within MC, carriers of two mutations in Parkin and PINK1 showed higher UPSIT percentiles than LRRK2 and SNCA carriers. Color discrimination was reduced in IPD (FM total error score 134.8 ± 92.7). In MC (122.4 ± 142.4), the reduction was most pronounced in LRRK2, NMC (80.0 ± 38.8) were comparable with controls (97.2 ± 61.1). UPSIT and FM scores were correlated in the control (r = -0.305; P = 0.002) and the IPD group (r = -0.303; P = 0.006) but not among mutation carriers. First, we confirmed olfaction and color discrimination to be impaired in IPD and suggest olfaction to be a premotor sign. Second, olfaction differed between carriers with one and two mutations in Parkin/PINK1-associated PD. Third, olfaction and color discrimination impairment do not necessarily evolve in parallel.

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Mutation

KW - Statistics, Nonparametric

KW - Genetic Testing

KW - Parkinson Disease genetics

KW - Discrimination (Psychology) physiology

KW - Color Perception genetics

KW - Color Vision Defects genetics

KW - Olfaction Disorders genetics

KW - Smell genetics

KW - alpha-Synuclein genetics

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Mutation

KW - Statistics, Nonparametric

KW - Genetic Testing

KW - Parkinson Disease genetics

KW - Discrimination (Psychology) physiology

KW - Color Perception genetics

KW - Color Vision Defects genetics

KW - Olfaction Disorders genetics

KW - Smell genetics

KW - alpha-Synuclein genetics

M3 - SCORING: Journal article

VL - 25

SP - 2665

EP - 2669

JO - MOVEMENT DISORD

JF - MOVEMENT DISORD

SN - 0885-3185

IS - 15

M1 - 15

ER -