Impaired eye blink classical conditioning distinguishes dystonic patients with and without tremor

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Impaired eye blink classical conditioning distinguishes dystonic patients with and without tremor. / Antelmi, E; Di Stasio, F; Rocchi, L; Erro, R; Liguori, R; Ganos, C; Brugger, F; Teo, J; Berardelli, A; Rothwell, J; Bhatia, K P.

in: PARKINSONISM RELAT D, Jahrgang 31, 10.2016, S. 23-27.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

Harvard

Antelmi, E, Di Stasio, F, Rocchi, L, Erro, R, Liguori, R, Ganos, C, Brugger, F, Teo, J, Berardelli, A, Rothwell, J & Bhatia, KP 2016, 'Impaired eye blink classical conditioning distinguishes dystonic patients with and without tremor', PARKINSONISM RELAT D, Jg. 31, S. 23-27. https://doi.org/10.1016/j.parkreldis.2016.06.011

APA

Antelmi, E., Di Stasio, F., Rocchi, L., Erro, R., Liguori, R., Ganos, C., Brugger, F., Teo, J., Berardelli, A., Rothwell, J., & Bhatia, K. P. (2016). Impaired eye blink classical conditioning distinguishes dystonic patients with and without tremor. PARKINSONISM RELAT D, 31, 23-27. https://doi.org/10.1016/j.parkreldis.2016.06.011

Vancouver

Bibtex

@article{9da7d6508b9e4bfeb61357bdeabdeead,
title = "Impaired eye blink classical conditioning distinguishes dystonic patients with and without tremor",
abstract = "INTRODUCTION: Tremor is frequently associated with dystonia, but its pathophysiology is still unclear. Dysfunctions of cerebellar circuits are known to play a role in the pathophysiology of action-induced tremors, and cerebellar impairment has frequently been associated to dystonia. However, a link between dystonic tremor and cerebellar abnormalities has not been demonstrated so far.METHODS: Twenty-five patients with idiopathic isolated cervical dystonia, with and without tremor, were enrolled. We studied the excitability of inhibitory circuits in the brainstem by measuring the R2 blink reflex recovery cycle (BRC) and implicit learning mediated by the cerebellum by means of eyeblink classical conditioning (EBCC). Results were compared with those obtained in a group of age-matched healthy subjects (HS).RESULTS: Statistical analysis did not disclose any significant clinical differences among dystonic patients with and without tremor. Patients with dystonia (regardless of the presence of tremor) showed decreased inhibition of R2 blink reflex by conditioning pulses compared with HS. Patients with dystonic tremor showed a decreased number of conditioned responses in the EBCC paradigm compared to HS and dystonic patients without tremor.CONCLUSION: The present data show that cerebellar impairment segregates with the presence of tremor in patients with dystonia, suggesting that the cerebellum might have a role in the occurrence of dystonic tremor.",
author = "E Antelmi and {Di Stasio}, F and L Rocchi and R Erro and R Liguori and C Ganos and F Brugger and J Teo and A Berardelli and J Rothwell and Bhatia, {K P}",
note = "Copyright {\textcopyright} 2016 Elsevier Ltd. All rights reserved.",
year = "2016",
month = oct,
doi = "10.1016/j.parkreldis.2016.06.011",
language = "English",
volume = "31",
pages = "23--27",
journal = "PARKINSONISM RELAT D",
issn = "1353-8020",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Impaired eye blink classical conditioning distinguishes dystonic patients with and without tremor

AU - Antelmi, E

AU - Di Stasio, F

AU - Rocchi, L

AU - Erro, R

AU - Liguori, R

AU - Ganos, C

AU - Brugger, F

AU - Teo, J

AU - Berardelli, A

AU - Rothwell, J

AU - Bhatia, K P

N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.

PY - 2016/10

Y1 - 2016/10

N2 - INTRODUCTION: Tremor is frequently associated with dystonia, but its pathophysiology is still unclear. Dysfunctions of cerebellar circuits are known to play a role in the pathophysiology of action-induced tremors, and cerebellar impairment has frequently been associated to dystonia. However, a link between dystonic tremor and cerebellar abnormalities has not been demonstrated so far.METHODS: Twenty-five patients with idiopathic isolated cervical dystonia, with and without tremor, were enrolled. We studied the excitability of inhibitory circuits in the brainstem by measuring the R2 blink reflex recovery cycle (BRC) and implicit learning mediated by the cerebellum by means of eyeblink classical conditioning (EBCC). Results were compared with those obtained in a group of age-matched healthy subjects (HS).RESULTS: Statistical analysis did not disclose any significant clinical differences among dystonic patients with and without tremor. Patients with dystonia (regardless of the presence of tremor) showed decreased inhibition of R2 blink reflex by conditioning pulses compared with HS. Patients with dystonic tremor showed a decreased number of conditioned responses in the EBCC paradigm compared to HS and dystonic patients without tremor.CONCLUSION: The present data show that cerebellar impairment segregates with the presence of tremor in patients with dystonia, suggesting that the cerebellum might have a role in the occurrence of dystonic tremor.

AB - INTRODUCTION: Tremor is frequently associated with dystonia, but its pathophysiology is still unclear. Dysfunctions of cerebellar circuits are known to play a role in the pathophysiology of action-induced tremors, and cerebellar impairment has frequently been associated to dystonia. However, a link between dystonic tremor and cerebellar abnormalities has not been demonstrated so far.METHODS: Twenty-five patients with idiopathic isolated cervical dystonia, with and without tremor, were enrolled. We studied the excitability of inhibitory circuits in the brainstem by measuring the R2 blink reflex recovery cycle (BRC) and implicit learning mediated by the cerebellum by means of eyeblink classical conditioning (EBCC). Results were compared with those obtained in a group of age-matched healthy subjects (HS).RESULTS: Statistical analysis did not disclose any significant clinical differences among dystonic patients with and without tremor. Patients with dystonia (regardless of the presence of tremor) showed decreased inhibition of R2 blink reflex by conditioning pulses compared with HS. Patients with dystonic tremor showed a decreased number of conditioned responses in the EBCC paradigm compared to HS and dystonic patients without tremor.CONCLUSION: The present data show that cerebellar impairment segregates with the presence of tremor in patients with dystonia, suggesting that the cerebellum might have a role in the occurrence of dystonic tremor.

U2 - 10.1016/j.parkreldis.2016.06.011

DO - 10.1016/j.parkreldis.2016.06.011

M3 - SCORING: Journal article

C2 - 27388270

VL - 31

SP - 23

EP - 27

JO - PARKINSONISM RELAT D

JF - PARKINSONISM RELAT D

SN - 1353-8020

ER -