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Impaired contractile performance of cultured rabbit ventricular myocytes after adenoviral gene transfer of Na(+)-Ca(2+) exchanger.

Standard

Impaired contractile performance of cultured rabbit ventricular myocytes after adenoviral gene transfer of Na(+)-Ca(2+) exchanger. / Schillinger, W; Janssen, P M; Emami, S; Henderson, S A; Ross, R S; Teucher, N; Zeitz, Oliver; Philipson, K D; Prestle, J; Hasenfuss, G.

in: CIRC RES, Jahrgang 87, Nr. 7, 7, 2000, S. 581-587.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schillinger, W, Janssen, PM, Emami, S, Henderson, SA, Ross, RS, Teucher, N, Zeitz, O, Philipson, KD, Prestle, J & Hasenfuss, G 2000, 'Impaired contractile performance of cultured rabbit ventricular myocytes after adenoviral gene transfer of Na(+)-Ca(2+) exchanger.', CIRC RES, Jg. 87, Nr. 7, 7, S. 581-587. <http://www.ncbi.nlm.nih.gov/pubmed/11009563?dopt=Citation>

APA

Schillinger, W., Janssen, P. M., Emami, S., Henderson, S. A., Ross, R. S., Teucher, N., Zeitz, O., Philipson, K. D., Prestle, J., & Hasenfuss, G. (2000). Impaired contractile performance of cultured rabbit ventricular myocytes after adenoviral gene transfer of Na(+)-Ca(2+) exchanger. CIRC RES, 87(7), 581-587. [7]. http://www.ncbi.nlm.nih.gov/pubmed/11009563?dopt=Citation

Vancouver

Schillinger W, Janssen PM, Emami S, Henderson SA, Ross RS, Teucher N et al. Impaired contractile performance of cultured rabbit ventricular myocytes after adenoviral gene transfer of Na(+)-Ca(2+) exchanger. CIRC RES. 2000;87(7):581-587. 7.

Bibtex

@article{9e38807c42c740e3b86ac894ffa97779,
title = "Impaired contractile performance of cultured rabbit ventricular myocytes after adenoviral gene transfer of Na(+)-Ca(2+) exchanger.",
abstract = "Na(+)-Ca(2+) exchanger (NCX) gene expression is increased in the failing human heart. We investigated the hypothesis that upregulation of NCX can induce depressed contractile performance. Overexpression of NCX was achieved in isolated rabbit ventricular myocytes through adenoviral gene transfer (Ad-NCX). After 48 hours, immunoblots revealed a virus dose-dependent increase in NCX protein. Adenoviral beta-galactosidase transfection served as a control. The fractional shortening (FS) of electrically stimulated myocytes was analyzed. At 60 min(-1), FS was depressed by 15.6% in the Ad-NCX group (n=143) versus the control group (n=163, P:",
author = "W Schillinger and Janssen, {P M} and S Emami and Henderson, {S A} and Ross, {R S} and N Teucher and Oliver Zeitz and Philipson, {K D} and J Prestle and G Hasenfuss",
year = "2000",
language = "Deutsch",
volume = "87",
pages = "581--587",
journal = "CIRC RES",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

RIS

TY - JOUR

T1 - Impaired contractile performance of cultured rabbit ventricular myocytes after adenoviral gene transfer of Na(+)-Ca(2+) exchanger.

AU - Schillinger, W

AU - Janssen, P M

AU - Emami, S

AU - Henderson, S A

AU - Ross, R S

AU - Teucher, N

AU - Zeitz, Oliver

AU - Philipson, K D

AU - Prestle, J

AU - Hasenfuss, G

PY - 2000

Y1 - 2000

N2 - Na(+)-Ca(2+) exchanger (NCX) gene expression is increased in the failing human heart. We investigated the hypothesis that upregulation of NCX can induce depressed contractile performance. Overexpression of NCX was achieved in isolated rabbit ventricular myocytes through adenoviral gene transfer (Ad-NCX). After 48 hours, immunoblots revealed a virus dose-dependent increase in NCX protein. Adenoviral beta-galactosidase transfection served as a control. The fractional shortening (FS) of electrically stimulated myocytes was analyzed. At 60 min(-1), FS was depressed by 15.6% in the Ad-NCX group (n=143) versus the control group (n=163, P:

AB - Na(+)-Ca(2+) exchanger (NCX) gene expression is increased in the failing human heart. We investigated the hypothesis that upregulation of NCX can induce depressed contractile performance. Overexpression of NCX was achieved in isolated rabbit ventricular myocytes through adenoviral gene transfer (Ad-NCX). After 48 hours, immunoblots revealed a virus dose-dependent increase in NCX protein. Adenoviral beta-galactosidase transfection served as a control. The fractional shortening (FS) of electrically stimulated myocytes was analyzed. At 60 min(-1), FS was depressed by 15.6% in the Ad-NCX group (n=143) versus the control group (n=163, P:

M3 - SCORING: Zeitschriftenaufsatz

VL - 87

SP - 581

EP - 587

JO - CIRC RES

JF - CIRC RES

SN - 0009-7330

IS - 7

M1 - 7

ER -