Impact of the localization on disease course and clinical management in spondylodiscitis

Martin Stangenberg; Malte Mohme; Klaus Christian Mende; Darius Maximilian Thiesen; Theresa Krätzig; Benjamin Schoof; Sven Oliver Eicker; Marc Dreimann

doi:10.1016/j.ijid.2020.07.028

Impact of the localization on disease course and clinical management in spondylodiscitis

Standard

Impact of the localization on disease course and clinical management in spondylodiscitis. / Stangenberg, Martin; Mohme, Malte; Mende, Klaus Christian; Thiesen, Darius Maximilian; Krätzig, Theresa; Schoof, Benjamin; Eicker, Sven Oliver; Dreimann, Marc.

in: INT J INFECT DIS, Jahrgang 99, 10.2020, S. 122-130.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Stangenberg, M, Mohme, M, Mende, KC, Thiesen, DM, Krätzig, T, Schoof, B, Eicker, SO & Dreimann, M 2020, 'Impact of the localization on disease course and clinical management in spondylodiscitis', INT J INFECT DIS, Jg. 99, S. 122-130. https://doi.org/10.1016/j.ijid.2020.07.028

APA

Stangenberg, M., Mohme, M., Mende, K. C., Thiesen, D. M., Krätzig, T., Schoof, B., Eicker, S. O., & Dreimann, M. (2020). Impact of the localization on disease course and clinical management in spondylodiscitis. INT J INFECT DIS, 99, 122-130. https://doi.org/10.1016/j.ijid.2020.07.028

Vancouver

Stangenberg M, Mohme M, Mende KC, Thiesen DM, Krätzig T, Schoof B et al. Impact of the localization on disease course and clinical management in spondylodiscitis. INT J INFECT DIS. 2020 Okt;99:122-130. https://doi.org/10.1016/j.ijid.2020.07.028

Bibtex

@article{961549c8690043eca43d12f541b3cd48,

title = "Impact of the localization on disease course and clinical management in spondylodiscitis",

abstract = "OBJECTIVES: Spondylodiscitis is a severe infection of the spine that can take a diverse number of disease courses depending on its localization, resulting in specific therapeutic strategies. This study aims to identify localization specific characteristics and clinical parameters for spondylodiscitis.METHODS: A retrospective review was performed of 211 patients from 2013-2018 with proven spondylodiscitis. In total, 33 were cervical, 48 thoracic and 112 lumbar. In 18 patients disseminated infestations of several localizations were found. The patient records were evaluated for clinical and outcome parameters and demographic characteristics.RESULTS: Patient age, Body Mass Index, inpatient and intensive care stay, and inpatient complications did not differ significantly between different infection localizations. C-reactive protein (CrP) levels showed a significantly reduced value in the thoracic area compared to other localizations. For comorbidities, there was a significantly higher prevalence of endocarditis in disseminated and lumbar infestations compared to thoracic and cervical cases. Epidural abscesses showed a highly increased incidence in cervical cases. With a 30-day mortality rate of 12.1% for cervical, 12.5% thoracic, 13.4% lumbar, and 22.2% in disseminated disease, no significant difference was observed.CONCLUSIONS: The present study determined that, although the 30-day mortality rate does not differ according to the localization of the infection, specific clinical parameters, such as CrP values or comorbidities, showed localization-dependent differences.",

keywords = "Adult, Aged, Aged, 80 and over, Discitis/diagnosis, Epidural Abscess, Female, Humans, Male, Middle Aged, Retrospective Studies, Young Adult",

author = "Martin Stangenberg and Malte Mohme and Mende, {Klaus Christian} and Thiesen, {Darius Maximilian} and Theresa Kr{\"a}tzig and Benjamin Schoof and Eicker, {Sven Oliver} and Marc Dreimann",

year = "2020",

month = oct,

doi = "10.1016/j.ijid.2020.07.028",

language = "English",

volume = "99",

pages = "122--130",

journal = "INT J INFECT DIS",

issn = "1201-9712",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Impact of the localization on disease course and clinical management in spondylodiscitis

AU - Stangenberg, Martin

AU - Mohme, Malte

AU - Mende, Klaus Christian

AU - Thiesen, Darius Maximilian

AU - Krätzig, Theresa

AU - Schoof, Benjamin

AU - Eicker, Sven Oliver

AU - Dreimann, Marc

PY - 2020/10

Y1 - 2020/10

N2 - OBJECTIVES: Spondylodiscitis is a severe infection of the spine that can take a diverse number of disease courses depending on its localization, resulting in specific therapeutic strategies. This study aims to identify localization specific characteristics and clinical parameters for spondylodiscitis.METHODS: A retrospective review was performed of 211 patients from 2013-2018 with proven spondylodiscitis. In total, 33 were cervical, 48 thoracic and 112 lumbar. In 18 patients disseminated infestations of several localizations were found. The patient records were evaluated for clinical and outcome parameters and demographic characteristics.RESULTS: Patient age, Body Mass Index, inpatient and intensive care stay, and inpatient complications did not differ significantly between different infection localizations. C-reactive protein (CrP) levels showed a significantly reduced value in the thoracic area compared to other localizations. For comorbidities, there was a significantly higher prevalence of endocarditis in disseminated and lumbar infestations compared to thoracic and cervical cases. Epidural abscesses showed a highly increased incidence in cervical cases. With a 30-day mortality rate of 12.1% for cervical, 12.5% thoracic, 13.4% lumbar, and 22.2% in disseminated disease, no significant difference was observed.CONCLUSIONS: The present study determined that, although the 30-day mortality rate does not differ according to the localization of the infection, specific clinical parameters, such as CrP values or comorbidities, showed localization-dependent differences.

AB - OBJECTIVES: Spondylodiscitis is a severe infection of the spine that can take a diverse number of disease courses depending on its localization, resulting in specific therapeutic strategies. This study aims to identify localization specific characteristics and clinical parameters for spondylodiscitis.METHODS: A retrospective review was performed of 211 patients from 2013-2018 with proven spondylodiscitis. In total, 33 were cervical, 48 thoracic and 112 lumbar. In 18 patients disseminated infestations of several localizations were found. The patient records were evaluated for clinical and outcome parameters and demographic characteristics.RESULTS: Patient age, Body Mass Index, inpatient and intensive care stay, and inpatient complications did not differ significantly between different infection localizations. C-reactive protein (CrP) levels showed a significantly reduced value in the thoracic area compared to other localizations. For comorbidities, there was a significantly higher prevalence of endocarditis in disseminated and lumbar infestations compared to thoracic and cervical cases. Epidural abscesses showed a highly increased incidence in cervical cases. With a 30-day mortality rate of 12.1% for cervical, 12.5% thoracic, 13.4% lumbar, and 22.2% in disseminated disease, no significant difference was observed.CONCLUSIONS: The present study determined that, although the 30-day mortality rate does not differ according to the localization of the infection, specific clinical parameters, such as CrP values or comorbidities, showed localization-dependent differences.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Discitis/diagnosis

KW - Epidural Abscess

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Retrospective Studies

KW - Young Adult

U2 - 10.1016/j.ijid.2020.07.028

DO - 10.1016/j.ijid.2020.07.028

M3 - SCORING: Journal article

C2 - 32721536

VL - 99

SP - 122

EP - 130

JO - INT J INFECT DIS

JF - INT J INFECT DIS

SN - 1201-9712

ER -