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Impact of the Level of Urothelial Carcinoma Involvement of the Prostate on Survival after Radical Cystectomy

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Impact of the Level of Urothelial Carcinoma Involvement of the Prostate on Survival after Radical Cystectomy. / Moschini, Marco; Soria, Francesco; Susani, Martin; Korn, Stephan; Briganti, Alberto; Roupret, Morgan; Seitz, Christian; Gust, Killian; Haitel, Andrea; Montorsi, Francesco; Wirth, Gregory; Robinson, Brian D; Karakiewicz, Pierre I; Özsoy, Mehmet; Rink, Michael; Shariat, Shahrokh F.

in: Bladder Cancer, Jahrgang 3, Nr. 3, 27.07.2017, S. 161-169.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Moschini, M, Soria, F, Susani, M, Korn, S, Briganti, A, Roupret, M, Seitz, C, Gust, K, Haitel, A, Montorsi, F, Wirth, G, Robinson, BD, Karakiewicz, PI, Özsoy, M, Rink, M & Shariat, SF 2017, 'Impact of the Level of Urothelial Carcinoma Involvement of the Prostate on Survival after Radical Cystectomy', Bladder Cancer, Jg. 3, Nr. 3, S. 161-169. https://doi.org/10.3233/BLC-160086

APA

Moschini, M., Soria, F., Susani, M., Korn, S., Briganti, A., Roupret, M., Seitz, C., Gust, K., Haitel, A., Montorsi, F., Wirth, G., Robinson, B. D., Karakiewicz, P. I., Özsoy, M., Rink, M., & Shariat, S. F. (2017). Impact of the Level of Urothelial Carcinoma Involvement of the Prostate on Survival after Radical Cystectomy. Bladder Cancer, 3(3), 161-169. https://doi.org/10.3233/BLC-160086

Vancouver

Moschini M, Soria F, Susani M, Korn S, Briganti A, Roupret M et al. Impact of the Level of Urothelial Carcinoma Involvement of the Prostate on Survival after Radical Cystectomy. Bladder Cancer. 2017 Jul 27;3(3):161-169. https://doi.org/10.3233/BLC-160086

Bibtex

@article{3b3a7f4c50c148f6bc664fff2033c93c,
title = "Impact of the Level of Urothelial Carcinoma Involvement of the Prostate on Survival after Radical Cystectomy",
abstract = "OBJECTIVE: Urothelial prostatic involvement (UPI) at the time of radical cystoprostatectomy (RCP) was found associated with worse survival outcomes by several previous reports. Our aim is to evaluate the impact of different levels of UPI on survival outcomes using a large series of male patients treated with RCP.METHODS: Whole step section specimens from 995 male BCa patients were assessed for UPI defined as: no involvement vs. prostatic urethral carcinomain situ(CIS) vs. lamina propria involvement vs. ductal CIS vs. prostate stromal involvement. Primary end point of the study was predictors of prostatic involvement at RCP and its impact on overall survival after surgery.RESULTS: Prostatic involvement was recorded in 307 (30.9%) patients: 28% with prostatic urethral CIS, 12% with lamina propria involvement, 13% with ductal CIS and 47% with stromal involvement. Median follow-up was 70 months. Patients with stromal involvement had a worse 5-year survival (12%) than those with prostatic urethra CIS (40%), lamina propria involvement (36%), and ductal CIS (35%). Considering predictors of prostatic involvement, multifocal tumor (Odds Ratio [OR]: 6.60,p < 0.001), lymphovascular invasion (OR: 2.61,p < 0.001), lymph node metastases (OR: 2.02,p < 0.001) and CIS (OR: 2.02,p < 0.001) were found associated. Similar predictors were found assessing stromal involvement.CONCLUSIONS: Approximately one third of RCP patients harbor prostatic involvement of urothelial carcinoma. While all UPI are associated with worse overall survival, stromal involvement confers the worst outcome supporting its classification as T4 in the TNM staging.",
keywords = "Journal Article",
author = "Marco Moschini and Francesco Soria and Martin Susani and Stephan Korn and Alberto Briganti and Morgan Roupret and Christian Seitz and Killian Gust and Andrea Haitel and Francesco Montorsi and Gregory Wirth and Robinson, {Brian D} and Karakiewicz, {Pierre I} and Mehmet {\"O}zsoy and Michael Rink and Shariat, {Shahrokh F}",
year = "2017",
month = jul,
day = "27",
doi = "10.3233/BLC-160086",
language = "English",
volume = "3",
pages = "161--169",
journal = "Bladder Cancer",
issn = "2352-3727",
publisher = "IOS Press",
number = "3",

}

RIS

TY - JOUR

T1 - Impact of the Level of Urothelial Carcinoma Involvement of the Prostate on Survival after Radical Cystectomy

AU - Moschini, Marco

AU - Soria, Francesco

AU - Susani, Martin

AU - Korn, Stephan

AU - Briganti, Alberto

AU - Roupret, Morgan

AU - Seitz, Christian

AU - Gust, Killian

AU - Haitel, Andrea

AU - Montorsi, Francesco

AU - Wirth, Gregory

AU - Robinson, Brian D

AU - Karakiewicz, Pierre I

AU - Özsoy, Mehmet

AU - Rink, Michael

AU - Shariat, Shahrokh F

PY - 2017/7/27

Y1 - 2017/7/27

N2 - OBJECTIVE: Urothelial prostatic involvement (UPI) at the time of radical cystoprostatectomy (RCP) was found associated with worse survival outcomes by several previous reports. Our aim is to evaluate the impact of different levels of UPI on survival outcomes using a large series of male patients treated with RCP.METHODS: Whole step section specimens from 995 male BCa patients were assessed for UPI defined as: no involvement vs. prostatic urethral carcinomain situ(CIS) vs. lamina propria involvement vs. ductal CIS vs. prostate stromal involvement. Primary end point of the study was predictors of prostatic involvement at RCP and its impact on overall survival after surgery.RESULTS: Prostatic involvement was recorded in 307 (30.9%) patients: 28% with prostatic urethral CIS, 12% with lamina propria involvement, 13% with ductal CIS and 47% with stromal involvement. Median follow-up was 70 months. Patients with stromal involvement had a worse 5-year survival (12%) than those with prostatic urethra CIS (40%), lamina propria involvement (36%), and ductal CIS (35%). Considering predictors of prostatic involvement, multifocal tumor (Odds Ratio [OR]: 6.60,p < 0.001), lymphovascular invasion (OR: 2.61,p < 0.001), lymph node metastases (OR: 2.02,p < 0.001) and CIS (OR: 2.02,p < 0.001) were found associated. Similar predictors were found assessing stromal involvement.CONCLUSIONS: Approximately one third of RCP patients harbor prostatic involvement of urothelial carcinoma. While all UPI are associated with worse overall survival, stromal involvement confers the worst outcome supporting its classification as T4 in the TNM staging.

AB - OBJECTIVE: Urothelial prostatic involvement (UPI) at the time of radical cystoprostatectomy (RCP) was found associated with worse survival outcomes by several previous reports. Our aim is to evaluate the impact of different levels of UPI on survival outcomes using a large series of male patients treated with RCP.METHODS: Whole step section specimens from 995 male BCa patients were assessed for UPI defined as: no involvement vs. prostatic urethral carcinomain situ(CIS) vs. lamina propria involvement vs. ductal CIS vs. prostate stromal involvement. Primary end point of the study was predictors of prostatic involvement at RCP and its impact on overall survival after surgery.RESULTS: Prostatic involvement was recorded in 307 (30.9%) patients: 28% with prostatic urethral CIS, 12% with lamina propria involvement, 13% with ductal CIS and 47% with stromal involvement. Median follow-up was 70 months. Patients with stromal involvement had a worse 5-year survival (12%) than those with prostatic urethra CIS (40%), lamina propria involvement (36%), and ductal CIS (35%). Considering predictors of prostatic involvement, multifocal tumor (Odds Ratio [OR]: 6.60,p < 0.001), lymphovascular invasion (OR: 2.61,p < 0.001), lymph node metastases (OR: 2.02,p < 0.001) and CIS (OR: 2.02,p < 0.001) were found associated. Similar predictors were found assessing stromal involvement.CONCLUSIONS: Approximately one third of RCP patients harbor prostatic involvement of urothelial carcinoma. While all UPI are associated with worse overall survival, stromal involvement confers the worst outcome supporting its classification as T4 in the TNM staging.

KW - Journal Article

U2 - 10.3233/BLC-160086

DO - 10.3233/BLC-160086

M3 - SCORING: Journal article

C2 - 28824943

VL - 3

SP - 161

EP - 169

JO - Bladder Cancer

JF - Bladder Cancer

SN - 2352-3727

IS - 3

ER -