Impact of statin use on biochemical recurrence in patients treated with radical prostatectomy

  • M Rieken
  • L A Kluth
  • E Xylinas
  • C Seitz
  • H Fajkovic
  • P I Karakiewicz
  • Y Lotan
  • A Briganti
  • W Loidl
  • T Faison
  • J J Crivelli
  • D S Scherr
  • A Bachmann
  • A K Tewari
  • A Kautzky-Willer
  • K Pummer
  • S F Shariat

Beteiligte Einrichtungen

Abstract

BACKGROUND: The impact of statin use on biochemical recurrence (BCR) in patients treated with radical prostatectomy (RP) remains controversial.

METHODS: We retrospectively evaluated 6842 patients who underwent RP for clinically localized prostate cancer (PC) between 2000 and 2011. Uni- and multivariable cox regression models addressed the association of statin use with BCR.

RESULTS: Overall, 2275 (33.3%) patients used statins. Statin users were older and had a higher rate of positive surgical margins than patients not using statins (P-values 0.05). Within a median follow-up of 25 months (interquartile range: 8-42 months), 778 (11.4%) patients experienced BCR. Actuarial estimate 5-years BCR-free survival was 82%±1 for patients without statin use and 84±1% for patients using statins (P=0.05); statin use was not associated with BCR (hazard ratio: 0.88, 95% confidence interval: 0.76-1.03, P=0.10) after adjusting for the effects of standard clinicopathologic features.

CONCLUSIONS: In PC patients undergoing RP, statin use was not independently associated with lower risk of BCR.

Bibliografische Daten

OriginalspracheEnglisch
ISSN1365-7852
DOIs
StatusVeröffentlicht - 01.12.2013
PubMed 23999669