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Impact of smoking status on survival after cytoreductive nephrectomy for metastatic renal cell carcinoma

Standard

Impact of smoking status on survival after cytoreductive nephrectomy for metastatic renal cell carcinoma. / Fajkovic, Harun; Shariat, Shahrokh F; Klatte, Tobias; Vartolomei, Mihai Dorin; Lucca, Ilaria; Mbeutcha, Aurélie; Rouprêt, Morgan; Briganti, Alberto; Karakiewicz, Pierre I; Margulis, Vitaly; Rink, Michael; Remzi, Mesut; Seitz, Christian; Bensalah, Karim; Mathieu, Romain.

in: WORLD J UROL, Jahrgang 34, Nr. 10, 10.2016, S. 1411-9.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Fajkovic, H, Shariat, SF, Klatte, T, Vartolomei, MD, Lucca, I, Mbeutcha, A, Rouprêt, M, Briganti, A, Karakiewicz, PI, Margulis, V, Rink, M, Remzi, M, Seitz, C, Bensalah, K & Mathieu, R 2016, 'Impact of smoking status on survival after cytoreductive nephrectomy for metastatic renal cell carcinoma', WORLD J UROL, Jg. 34, Nr. 10, S. 1411-9. https://doi.org/10.1007/s00345-016-1767-9

APA

Fajkovic, H., Shariat, S. F., Klatte, T., Vartolomei, M. D., Lucca, I., Mbeutcha, A., Rouprêt, M., Briganti, A., Karakiewicz, P. I., Margulis, V., Rink, M., Remzi, M., Seitz, C., Bensalah, K., & Mathieu, R. (2016). Impact of smoking status on survival after cytoreductive nephrectomy for metastatic renal cell carcinoma. WORLD J UROL, 34(10), 1411-9. https://doi.org/10.1007/s00345-016-1767-9

Vancouver

Fajkovic H, Shariat SF, Klatte T, Vartolomei MD, Lucca I, Mbeutcha A et al. Impact of smoking status on survival after cytoreductive nephrectomy for metastatic renal cell carcinoma. WORLD J UROL. 2016 Okt;34(10):1411-9. https://doi.org/10.1007/s00345-016-1767-9

Bibtex

@article{a2549be940ac4a7eac3a13813e077608,
title = "Impact of smoking status on survival after cytoreductive nephrectomy for metastatic renal cell carcinoma",
abstract = "OBJECTIVE: To assess the association of smoking status with standard clinicopathological features and overall survival (OS) in a large multi-institutional cohort of patients with metastatic renal cell carcinoma (mRCC) treated with cytoreductive nephrectomy (CNT).METHODS: A total of 613 patients with mRCC treated with CNT in US and Europe institutions between 1990 and 2013 were included. Smoking history comprised smoking status, smoking duration in years, number of cigarettes per day and years since smoking cessation. Cumulative smoking exposure was categorized as light short term, heavy long term and moderate. Association between smoking history and OS was assessed by Cox regression logistic analysis.RESULTS: One hundred and seventy-one patients (27.9 %) never smoked, 193 (31.5 %) were former smokers and 249 (40.6 %) were current smokers. Smoking status was associated with a higher number of metastases (p < 0.001) and an abnormal preoperative corrected calcium level (p = 0.01). Median follow-up was 16 (IQR 7-24) months. Current smokers had a shorter OS than never and former smokers (log rank, p = 0.004). Smoking status was significantly associated with OS in univariable analysis (HR 1.45; 95 % CI 1.16-1.82; p < 0.001), and in multivariable analysis that adjusted for established prognostic factors (HR 1.46; 95 % CI 1.16-1.84; p = 0.002). Daily consumption of more than 20 cigarettes, more than 20 years of smoking exposure and heavy long exposure were all independent prognosticators of worse OS.CONCLUSIONS: Current smoking and a higher cumulative smoking exposure are associated with a higher risk of death in patients with mRCC treated with CNT. Even at this stage, smoking negatively affects kidney cancer outcomes.",
author = "Harun Fajkovic and Shariat, {Shahrokh F} and Tobias Klatte and Vartolomei, {Mihai Dorin} and Ilaria Lucca and Aur{\'e}lie Mbeutcha and Morgan Roupr{\^e}t and Alberto Briganti and Karakiewicz, {Pierre I} and Vitaly Margulis and Michael Rink and Mesut Remzi and Christian Seitz and Karim Bensalah and Romain Mathieu",
year = "2016",
month = oct,
doi = "10.1007/s00345-016-1767-9",
language = "English",
volume = "34",
pages = "1411--9",
journal = "WORLD J UROL",
issn = "0724-4983",
publisher = "Springer",
number = "10",

}

RIS

TY - JOUR

T1 - Impact of smoking status on survival after cytoreductive nephrectomy for metastatic renal cell carcinoma

AU - Fajkovic, Harun

AU - Shariat, Shahrokh F

AU - Klatte, Tobias

AU - Vartolomei, Mihai Dorin

AU - Lucca, Ilaria

AU - Mbeutcha, Aurélie

AU - Rouprêt, Morgan

AU - Briganti, Alberto

AU - Karakiewicz, Pierre I

AU - Margulis, Vitaly

AU - Rink, Michael

AU - Remzi, Mesut

AU - Seitz, Christian

AU - Bensalah, Karim

AU - Mathieu, Romain

PY - 2016/10

Y1 - 2016/10

N2 - OBJECTIVE: To assess the association of smoking status with standard clinicopathological features and overall survival (OS) in a large multi-institutional cohort of patients with metastatic renal cell carcinoma (mRCC) treated with cytoreductive nephrectomy (CNT).METHODS: A total of 613 patients with mRCC treated with CNT in US and Europe institutions between 1990 and 2013 were included. Smoking history comprised smoking status, smoking duration in years, number of cigarettes per day and years since smoking cessation. Cumulative smoking exposure was categorized as light short term, heavy long term and moderate. Association between smoking history and OS was assessed by Cox regression logistic analysis.RESULTS: One hundred and seventy-one patients (27.9 %) never smoked, 193 (31.5 %) were former smokers and 249 (40.6 %) were current smokers. Smoking status was associated with a higher number of metastases (p < 0.001) and an abnormal preoperative corrected calcium level (p = 0.01). Median follow-up was 16 (IQR 7-24) months. Current smokers had a shorter OS than never and former smokers (log rank, p = 0.004). Smoking status was significantly associated with OS in univariable analysis (HR 1.45; 95 % CI 1.16-1.82; p < 0.001), and in multivariable analysis that adjusted for established prognostic factors (HR 1.46; 95 % CI 1.16-1.84; p = 0.002). Daily consumption of more than 20 cigarettes, more than 20 years of smoking exposure and heavy long exposure were all independent prognosticators of worse OS.CONCLUSIONS: Current smoking and a higher cumulative smoking exposure are associated with a higher risk of death in patients with mRCC treated with CNT. Even at this stage, smoking negatively affects kidney cancer outcomes.

AB - OBJECTIVE: To assess the association of smoking status with standard clinicopathological features and overall survival (OS) in a large multi-institutional cohort of patients with metastatic renal cell carcinoma (mRCC) treated with cytoreductive nephrectomy (CNT).METHODS: A total of 613 patients with mRCC treated with CNT in US and Europe institutions between 1990 and 2013 were included. Smoking history comprised smoking status, smoking duration in years, number of cigarettes per day and years since smoking cessation. Cumulative smoking exposure was categorized as light short term, heavy long term and moderate. Association between smoking history and OS was assessed by Cox regression logistic analysis.RESULTS: One hundred and seventy-one patients (27.9 %) never smoked, 193 (31.5 %) were former smokers and 249 (40.6 %) were current smokers. Smoking status was associated with a higher number of metastases (p < 0.001) and an abnormal preoperative corrected calcium level (p = 0.01). Median follow-up was 16 (IQR 7-24) months. Current smokers had a shorter OS than never and former smokers (log rank, p = 0.004). Smoking status was significantly associated with OS in univariable analysis (HR 1.45; 95 % CI 1.16-1.82; p < 0.001), and in multivariable analysis that adjusted for established prognostic factors (HR 1.46; 95 % CI 1.16-1.84; p = 0.002). Daily consumption of more than 20 cigarettes, more than 20 years of smoking exposure and heavy long exposure were all independent prognosticators of worse OS.CONCLUSIONS: Current smoking and a higher cumulative smoking exposure are associated with a higher risk of death in patients with mRCC treated with CNT. Even at this stage, smoking negatively affects kidney cancer outcomes.

U2 - 10.1007/s00345-016-1767-9

DO - 10.1007/s00345-016-1767-9

M3 - SCORING: Journal article

C2 - 26879416

VL - 34

SP - 1411

EP - 1419

JO - WORLD J UROL

JF - WORLD J UROL

SN - 0724-4983

IS - 10

ER -