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Impact of single-room contact precautions on acquisition and transmission of vancomycin-resistant enterococci on haematological and oncological wards, multicentre cohort-study, Germany, January-December 2016

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Impact of single-room contact precautions on acquisition and transmission of vancomycin-resistant enterococci on haematological and oncological wards, multicentre cohort-study, Germany, January-December 2016. / Biehl, Lena M; Higgins, Paul G; Stemler, Jannik; Gilles, Meyke; Peter, Silke; Dörfel, Daniela; Vogel, Wichard; Kern, Winfried V; Gölz, Hanna; Bertz, Hartmut; Rohde, Holger; Klupp, Eva-Maria; Schafhausen, Philippe; Salmanton-García, Jon; Stecher, Melanie; Wille, Julia; Liss, Blasius; Xanthopoulou, Kyriaki; Zweigner, Janine; Seifert, Harald; Vehreschild, Maria J G T.

in: EUROSURVEILLANCE, Jahrgang 27, Nr. 2, 2001876, 01.2022.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Biehl, LM, Higgins, PG, Stemler, J, Gilles, M, Peter, S, Dörfel, D, Vogel, W, Kern, WV, Gölz, H, Bertz, H, Rohde, H, Klupp, E-M, Schafhausen, P, Salmanton-García, J, Stecher, M, Wille, J, Liss, B, Xanthopoulou, K, Zweigner, J, Seifert, H & Vehreschild, MJGT 2022, 'Impact of single-room contact precautions on acquisition and transmission of vancomycin-resistant enterococci on haematological and oncological wards, multicentre cohort-study, Germany, January-December 2016', EUROSURVEILLANCE, Jg. 27, Nr. 2, 2001876. https://doi.org/10.2807/1560-7917.ES.2022.27.2.2001876

APA

Biehl, L. M., Higgins, P. G., Stemler, J., Gilles, M., Peter, S., Dörfel, D., Vogel, W., Kern, W. V., Gölz, H., Bertz, H., Rohde, H., Klupp, E-M., Schafhausen, P., Salmanton-García, J., Stecher, M., Wille, J., Liss, B., Xanthopoulou, K., Zweigner, J., ... Vehreschild, M. J. G. T. (2022). Impact of single-room contact precautions on acquisition and transmission of vancomycin-resistant enterococci on haematological and oncological wards, multicentre cohort-study, Germany, January-December 2016. EUROSURVEILLANCE, 27(2), [2001876]. https://doi.org/10.2807/1560-7917.ES.2022.27.2.2001876

Vancouver

Biehl LM, Higgins PG, Stemler J, Gilles M, Peter S, Dörfel D et al. Impact of single-room contact precautions on acquisition and transmission of vancomycin-resistant enterococci on haematological and oncological wards, multicentre cohort-study, Germany, January-December 2016. EUROSURVEILLANCE. 2022 Jan;27(2). 2001876. https://doi.org/10.2807/1560-7917.ES.2022.27.2.2001876

Bibtex

@article{e43ee8726bf1473d93005472c5b2687f,
title = "Impact of single-room contact precautions on acquisition and transmission of vancomycin-resistant enterococci on haematological and oncological wards, multicentre cohort-study, Germany, January-December 2016",
abstract = "BackgroundEvidence supporting the effectiveness of single-room contact precautions (SCP) in preventing in-hospital acquisition of vancomycin-resistant enterococci (haVRE) is limited.AimWe assessed the impact of SCP on haVRE and their transmission.MethodsWe conducted a prospective, multicentre cohort study in German haematological/oncological departments during 2016. Two sites performed SCP for VRE patients and two did not (NCP). We defined a 5% haVRE-risk difference as non-inferiority margin, screened patients for VRE, and characterised isolates by whole genome sequencing and core genome MLST (cgMLST). Potential confounders were assessed by competing risk regression analysis.ResultsWe included 1,397 patients at NCP and 1,531 patients at SCP sites. Not performing SCP was associated with a significantly higher proportion of haVRE; 12.2% (170/1,397) patients at NCP and 7.4% (113/1,531) patients at SCP sites (relative risk (RR) 1.74; 95% confidence interval (CI): 1.35-2.23). The difference (4.8%) was below the non-inferiority margin. Competing risk regression analysis indicated a stronger impact of antimicrobial exposure (subdistribution hazard ratio (SHR) 7.46; 95% CI: 4.59-12.12) and underlying disease (SHR for acute leukaemia 2.34; 95% CI: 1.46-3.75) on haVRE than NCP (SHR 1.60; 95% CI: 1.14-2.25). Based on cgMLST and patient movement data, we observed 131 patient-to-patient VRE transmissions at NCP and 85 at SCP sites (RR 1.76; 95% CI: 1.33-2.34).ConclusionsWe show a positive impact of SCP on haVRE in a high-risk population, although the observed difference was below the pre-specified non-inferiority margin. Importantly, other factors including antimicrobial exposure seem to be more influential.",
author = "Biehl, {Lena M} and Higgins, {Paul G} and Jannik Stemler and Meyke Gilles and Silke Peter and Daniela D{\"o}rfel and Wichard Vogel and Kern, {Winfried V} and Hanna G{\"o}lz and Hartmut Bertz and Holger Rohde and Eva-Maria Klupp and Philippe Schafhausen and Jon Salmanton-Garc{\'i}a and Melanie Stecher and Julia Wille and Blasius Liss and Kyriaki Xanthopoulou and Janine Zweigner and Harald Seifert and Vehreschild, {Maria J G T}",
year = "2022",
month = jan,
doi = "10.2807/1560-7917.ES.2022.27.2.2001876",
language = "English",
volume = "27",
journal = "EUROSURVEILLANCE",
issn = "1025-496X",
publisher = "Centre Europeen pour la Surveillance Epidemiologique du SIDA",
number = "2",

}

RIS

TY - JOUR

T1 - Impact of single-room contact precautions on acquisition and transmission of vancomycin-resistant enterococci on haematological and oncological wards, multicentre cohort-study, Germany, January-December 2016

AU - Biehl, Lena M

AU - Higgins, Paul G

AU - Stemler, Jannik

AU - Gilles, Meyke

AU - Peter, Silke

AU - Dörfel, Daniela

AU - Vogel, Wichard

AU - Kern, Winfried V

AU - Gölz, Hanna

AU - Bertz, Hartmut

AU - Rohde, Holger

AU - Klupp, Eva-Maria

AU - Schafhausen, Philippe

AU - Salmanton-García, Jon

AU - Stecher, Melanie

AU - Wille, Julia

AU - Liss, Blasius

AU - Xanthopoulou, Kyriaki

AU - Zweigner, Janine

AU - Seifert, Harald

AU - Vehreschild, Maria J G T

PY - 2022/1

Y1 - 2022/1

N2 - BackgroundEvidence supporting the effectiveness of single-room contact precautions (SCP) in preventing in-hospital acquisition of vancomycin-resistant enterococci (haVRE) is limited.AimWe assessed the impact of SCP on haVRE and their transmission.MethodsWe conducted a prospective, multicentre cohort study in German haematological/oncological departments during 2016. Two sites performed SCP for VRE patients and two did not (NCP). We defined a 5% haVRE-risk difference as non-inferiority margin, screened patients for VRE, and characterised isolates by whole genome sequencing and core genome MLST (cgMLST). Potential confounders were assessed by competing risk regression analysis.ResultsWe included 1,397 patients at NCP and 1,531 patients at SCP sites. Not performing SCP was associated with a significantly higher proportion of haVRE; 12.2% (170/1,397) patients at NCP and 7.4% (113/1,531) patients at SCP sites (relative risk (RR) 1.74; 95% confidence interval (CI): 1.35-2.23). The difference (4.8%) was below the non-inferiority margin. Competing risk regression analysis indicated a stronger impact of antimicrobial exposure (subdistribution hazard ratio (SHR) 7.46; 95% CI: 4.59-12.12) and underlying disease (SHR for acute leukaemia 2.34; 95% CI: 1.46-3.75) on haVRE than NCP (SHR 1.60; 95% CI: 1.14-2.25). Based on cgMLST and patient movement data, we observed 131 patient-to-patient VRE transmissions at NCP and 85 at SCP sites (RR 1.76; 95% CI: 1.33-2.34).ConclusionsWe show a positive impact of SCP on haVRE in a high-risk population, although the observed difference was below the pre-specified non-inferiority margin. Importantly, other factors including antimicrobial exposure seem to be more influential.

AB - BackgroundEvidence supporting the effectiveness of single-room contact precautions (SCP) in preventing in-hospital acquisition of vancomycin-resistant enterococci (haVRE) is limited.AimWe assessed the impact of SCP on haVRE and their transmission.MethodsWe conducted a prospective, multicentre cohort study in German haematological/oncological departments during 2016. Two sites performed SCP for VRE patients and two did not (NCP). We defined a 5% haVRE-risk difference as non-inferiority margin, screened patients for VRE, and characterised isolates by whole genome sequencing and core genome MLST (cgMLST). Potential confounders were assessed by competing risk regression analysis.ResultsWe included 1,397 patients at NCP and 1,531 patients at SCP sites. Not performing SCP was associated with a significantly higher proportion of haVRE; 12.2% (170/1,397) patients at NCP and 7.4% (113/1,531) patients at SCP sites (relative risk (RR) 1.74; 95% confidence interval (CI): 1.35-2.23). The difference (4.8%) was below the non-inferiority margin. Competing risk regression analysis indicated a stronger impact of antimicrobial exposure (subdistribution hazard ratio (SHR) 7.46; 95% CI: 4.59-12.12) and underlying disease (SHR for acute leukaemia 2.34; 95% CI: 1.46-3.75) on haVRE than NCP (SHR 1.60; 95% CI: 1.14-2.25). Based on cgMLST and patient movement data, we observed 131 patient-to-patient VRE transmissions at NCP and 85 at SCP sites (RR 1.76; 95% CI: 1.33-2.34).ConclusionsWe show a positive impact of SCP on haVRE in a high-risk population, although the observed difference was below the pre-specified non-inferiority margin. Importantly, other factors including antimicrobial exposure seem to be more influential.

U2 - 10.2807/1560-7917.ES.2022.27.2.2001876

DO - 10.2807/1560-7917.ES.2022.27.2.2001876

M3 - SCORING: Journal article

C2 - 35027104

VL - 27

JO - EUROSURVEILLANCE

JF - EUROSURVEILLANCE

SN - 1025-496X

IS - 2

M1 - 2001876

ER -