Impact of rhBMP-2 on regeneration of buccal alveolar defects during the osseointegration of transgingival inserted implants.

Ralf Smeets; Oliver Maciejewski; Markus Gerressen; Hubertus Spiekermann; Oliver Hanisch; Dieter Riediger; Felix Blake; Jamal Stein; Frank Hölzle; Andreas Kolk

Impact of rhBMP-2 on regeneration of buccal alveolar defects during the osseointegration of transgingival inserted implants.

Standard

Impact of rhBMP-2 on regeneration of buccal alveolar defects during the osseointegration of transgingival inserted implants. / Smeets, Ralf; Maciejewski, Oliver; Gerressen, Markus; Spiekermann, Hubertus; Hanisch, Oliver; Riediger, Dieter; Blake, Felix; Stein, Jamal; Hölzle, Frank; Kolk, Andreas.

in: ORAL SURG ORAL MED O, Jahrgang 108, Nr. 4, 4, 2009, S. 3-12.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Smeets, R, Maciejewski, O, Gerressen, M, Spiekermann, H, Hanisch, O, Riediger, D, Blake, F, Stein, J, Hölzle, F & Kolk, A 2009, 'Impact of rhBMP-2 on regeneration of buccal alveolar defects during the osseointegration of transgingival inserted implants.', ORAL SURG ORAL MED O, Jg. 108, Nr. 4, 4, S. 3-12. <http://www.ncbi.nlm.nih.gov/pubmed/19716715?dopt=Citation>

APA

Smeets, R., Maciejewski, O., Gerressen, M., Spiekermann, H., Hanisch, O., Riediger, D., Blake, F., Stein, J., Hölzle, F., & Kolk, A. (2009). Impact of rhBMP-2 on regeneration of buccal alveolar defects during the osseointegration of transgingival inserted implants. ORAL SURG ORAL MED O, 108(4), 3-12. [4]. http://www.ncbi.nlm.nih.gov/pubmed/19716715?dopt=Citation

Vancouver

Smeets R, Maciejewski O, Gerressen M, Spiekermann H, Hanisch O, Riediger D et al. Impact of rhBMP-2 on regeneration of buccal alveolar defects during the osseointegration of transgingival inserted implants. ORAL SURG ORAL MED O. 2009;108(4):3-12. 4.

Bibtex

@article{7c74a140f56346578ab7c25cc3420619,

title = "Impact of rhBMP-2 on regeneration of buccal alveolar defects during the osseointegration of transgingival inserted implants.",

abstract = "OBJECTIVE: New approaches to enhance vertical bone regeneration in clinically relevant implant models are needed. Therefore, we analyzed the impact of recombinant human bone morphogenic protein 2 (rhBMP-2) on the healing of large buccal alveolar defects during osseointegration of transgingivally inserted implants. STUDY DESIGN: Twenty-four dental implants were inserted transgingivally in the mandibles of 6 labrador/golden retriever cross-bred dogs. Before implantation, a standardized buccal bone defect was created and refilled with either calcium phosphate as a carrier containing rhBMP-2 or calcium phosphate alone. Either ceramic abutments that enabled immediate implant loading or healing distance collars to prevent loading were mounted. Sixteen weeks after intervention, bone implant units were analyzed by radiofrequency analysis and histomorphometry. RESULTS: In total, 14 implants (58.3%) were available for further analysis. The mean depth of the bone defects, the gain of regenerated bone, the vertical osseointegration of the implants, and the bone-to-implant contact in the newly formed bone were slightly greater in the rhBMP-2-containing samples. In contrast, the osseointegration in the preexisting bone was even superior within the non-rhBMP-2-treated specimen. However no differences were statistically significant. CONCLUSIONS: When rhBMP-2-conducted bone regeneration was compared with control samples, no significant differences of newly formed bone were found at the bone-implant interface. The amounts of rhBMP-2 applied do not seem suitable to enhance implant osseointegration in large buccal defects.",

keywords = "Animals, Humans, Male, Time Factors, Recombinant Proteins therapeutic use, Alveolar Bone Loss pathology, Bone Matrix pathology, Bone Morphogenetic Proteins therapeutic use, Bone Regeneration drug effects, Calcium Phosphates, Ceramics chemistry, Dental Abutments, Dental Implants, Dental Materials chemistry, Dental Prosthesis Design, Dogs, Drug Carriers, Mandible pathology, Mandibular Diseases pathology, Osseointegration physiology, Osteoblasts pathology, Osteogenesis physiology, Surface Properties, Transforming Growth Factor beta therapeutic use, Animals, Humans, Male, Time Factors, Recombinant Proteins therapeutic use, Alveolar Bone Loss pathology, Bone Matrix pathology, Bone Morphogenetic Proteins therapeutic use, Bone Regeneration drug effects, Calcium Phosphates, Ceramics chemistry, Dental Abutments, Dental Implants, Dental Materials chemistry, Dental Prosthesis Design, Dogs, Drug Carriers, Mandible pathology, Mandibular Diseases pathology, Osseointegration physiology, Osteoblasts pathology, Osteogenesis physiology, Surface Properties, Transforming Growth Factor beta therapeutic use",

author = "Ralf Smeets and Oliver Maciejewski and Markus Gerressen and Hubertus Spiekermann and Oliver Hanisch and Dieter Riediger and Felix Blake and Jamal Stein and Frank H{\"o}lzle and Andreas Kolk",

year = "2009",

language = "Deutsch",

volume = "108",

pages = "3--12",

journal = "ORAL SURG ORAL MED O",

issn = "1079-2104",

publisher = "Mosby Inc.",

number = "4",

}

RIS

TY - JOUR

T1 - Impact of rhBMP-2 on regeneration of buccal alveolar defects during the osseointegration of transgingival inserted implants.

AU - Smeets, Ralf

AU - Maciejewski, Oliver

AU - Gerressen, Markus

AU - Spiekermann, Hubertus

AU - Hanisch, Oliver

AU - Riediger, Dieter

AU - Blake, Felix

AU - Stein, Jamal

AU - Hölzle, Frank

AU - Kolk, Andreas

PY - 2009

Y1 - 2009

N2 - OBJECTIVE: New approaches to enhance vertical bone regeneration in clinically relevant implant models are needed. Therefore, we analyzed the impact of recombinant human bone morphogenic protein 2 (rhBMP-2) on the healing of large buccal alveolar defects during osseointegration of transgingivally inserted implants. STUDY DESIGN: Twenty-four dental implants were inserted transgingivally in the mandibles of 6 labrador/golden retriever cross-bred dogs. Before implantation, a standardized buccal bone defect was created and refilled with either calcium phosphate as a carrier containing rhBMP-2 or calcium phosphate alone. Either ceramic abutments that enabled immediate implant loading or healing distance collars to prevent loading were mounted. Sixteen weeks after intervention, bone implant units were analyzed by radiofrequency analysis and histomorphometry. RESULTS: In total, 14 implants (58.3%) were available for further analysis. The mean depth of the bone defects, the gain of regenerated bone, the vertical osseointegration of the implants, and the bone-to-implant contact in the newly formed bone were slightly greater in the rhBMP-2-containing samples. In contrast, the osseointegration in the preexisting bone was even superior within the non-rhBMP-2-treated specimen. However no differences were statistically significant. CONCLUSIONS: When rhBMP-2-conducted bone regeneration was compared with control samples, no significant differences of newly formed bone were found at the bone-implant interface. The amounts of rhBMP-2 applied do not seem suitable to enhance implant osseointegration in large buccal defects.

AB - OBJECTIVE: New approaches to enhance vertical bone regeneration in clinically relevant implant models are needed. Therefore, we analyzed the impact of recombinant human bone morphogenic protein 2 (rhBMP-2) on the healing of large buccal alveolar defects during osseointegration of transgingivally inserted implants. STUDY DESIGN: Twenty-four dental implants were inserted transgingivally in the mandibles of 6 labrador/golden retriever cross-bred dogs. Before implantation, a standardized buccal bone defect was created and refilled with either calcium phosphate as a carrier containing rhBMP-2 or calcium phosphate alone. Either ceramic abutments that enabled immediate implant loading or healing distance collars to prevent loading were mounted. Sixteen weeks after intervention, bone implant units were analyzed by radiofrequency analysis and histomorphometry. RESULTS: In total, 14 implants (58.3%) were available for further analysis. The mean depth of the bone defects, the gain of regenerated bone, the vertical osseointegration of the implants, and the bone-to-implant contact in the newly formed bone were slightly greater in the rhBMP-2-containing samples. In contrast, the osseointegration in the preexisting bone was even superior within the non-rhBMP-2-treated specimen. However no differences were statistically significant. CONCLUSIONS: When rhBMP-2-conducted bone regeneration was compared with control samples, no significant differences of newly formed bone were found at the bone-implant interface. The amounts of rhBMP-2 applied do not seem suitable to enhance implant osseointegration in large buccal defects.

KW - Animals

KW - Humans

KW - Male

KW - Time Factors

KW - Recombinant Proteins therapeutic use

KW - Alveolar Bone Loss pathology

KW - Bone Matrix pathology

KW - Bone Morphogenetic Proteins therapeutic use

KW - Bone Regeneration drug effects

KW - Calcium Phosphates

KW - Ceramics chemistry

KW - Dental Abutments

KW - Dental Implants

KW - Dental Materials chemistry

KW - Dental Prosthesis Design

KW - Dogs

KW - Drug Carriers

KW - Mandible pathology

KW - Mandibular Diseases pathology

KW - Osseointegration physiology

KW - Osteoblasts pathology

KW - Osteogenesis physiology

KW - Surface Properties

KW - Transforming Growth Factor beta therapeutic use