Impact of physical activity and doping on epigenetic gene regulation.
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Impact of physical activity and doping on epigenetic gene regulation. / Schwarzenbach, Heidi.
in: DRUG TEST ANAL, Jahrgang 3, Nr. 10, 10, 2011, S. 682-687.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Impact of physical activity and doping on epigenetic gene regulation.
AU - Schwarzenbach, Heidi
PY - 2011
Y1 - 2011
N2 - To achieve success in sports, many athletes consume doping substances, such as anabolic androgenic steroids and growth hormones, and ignore the negative influence of these drugs on their health. Apart from the unethical aspect of doping in sports, it is essential to consider the tremendous risk it represents to their physical condition. The abuse of pharmaceuticals which improve athletic performance may alter the expression of specific genes involved in muscle and bone metabolism by epigenetic mechanisms, such as DNA methylation and histone modifications. Moreover, excessive and relentless training to increase the muscle mass, may also have an influence on the health of the athletes. This stress releases neurotransmitters and growth factors, and may affect the expression of endogenous genes by DNA methylation, too. This paper focuses on the relationship between epigenetic mechanisms and sports, highlights the potential consequences of abuse of doping drugs on gene expression, and describes methods to molecularly detect epigenetic changes of gene markers reflecting the physiological or metabolic effects of doping agents.
AB - To achieve success in sports, many athletes consume doping substances, such as anabolic androgenic steroids and growth hormones, and ignore the negative influence of these drugs on their health. Apart from the unethical aspect of doping in sports, it is essential to consider the tremendous risk it represents to their physical condition. The abuse of pharmaceuticals which improve athletic performance may alter the expression of specific genes involved in muscle and bone metabolism by epigenetic mechanisms, such as DNA methylation and histone modifications. Moreover, excessive and relentless training to increase the muscle mass, may also have an influence on the health of the athletes. This stress releases neurotransmitters and growth factors, and may affect the expression of endogenous genes by DNA methylation, too. This paper focuses on the relationship between epigenetic mechanisms and sports, highlights the potential consequences of abuse of doping drugs on gene expression, and describes methods to molecularly detect epigenetic changes of gene markers reflecting the physiological or metabolic effects of doping agents.
KW - Animals
KW - Humans
KW - Anabolic Agents/pharmacology
KW - DNA Methylation/drug effects
KW - Doping in Sports
KW - Epigenesis, Genetic/drug effects
KW - Growth Hormone/pharmacology
KW - Growth Substances/pharmacology
KW - Histones/genetics
KW - Insulin-Like Growth Factor I/pharmacology
KW - Motor Activity/drug effects
KW - Animals
KW - Humans
KW - Anabolic Agents/pharmacology
KW - DNA Methylation/drug effects
KW - Doping in Sports
KW - Epigenesis, Genetic/drug effects
KW - Growth Hormone/pharmacology
KW - Growth Substances/pharmacology
KW - Histones/genetics
KW - Insulin-Like Growth Factor I/pharmacology
KW - Motor Activity/drug effects
M3 - SCORING: Journal article
VL - 3
SP - 682
EP - 687
JO - DRUG TEST ANAL
JF - DRUG TEST ANAL
SN - 1942-7603
IS - 10
M1 - 10
ER -
