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Impact of cardiac surgery on plasma levels of B-type natriuretic peptide in children with congenital heart disease

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Impact of cardiac surgery on plasma levels of B-type natriuretic peptide in children with congenital heart disease. / Koch, Andreas; Kitzsteiner, Tobias; Zink, Stefan; Cesnjevar, Robert; Singer, Helmut.

in: INT J CARDIOL, Jahrgang 114, Nr. 3, 18.01.2007, S. 339-344.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Koch, A, Kitzsteiner, T, Zink, S, Cesnjevar, R & Singer, H 2007, 'Impact of cardiac surgery on plasma levels of B-type natriuretic peptide in children with congenital heart disease', INT J CARDIOL, Jg. 114, Nr. 3, S. 339-344. https://doi.org/10.1016/j.ijcard.2006.01.022

APA

Koch, A., Kitzsteiner, T., Zink, S., Cesnjevar, R., & Singer, H. (2007). Impact of cardiac surgery on plasma levels of B-type natriuretic peptide in children with congenital heart disease. INT J CARDIOL, 114(3), 339-344. https://doi.org/10.1016/j.ijcard.2006.01.022

Vancouver

Koch A, Kitzsteiner T, Zink S, Cesnjevar R, Singer H. Impact of cardiac surgery on plasma levels of B-type natriuretic peptide in children with congenital heart disease. INT J CARDIOL. 2007 Jan 18;114(3):339-344. https://doi.org/10.1016/j.ijcard.2006.01.022

Bibtex

@article{a91c6966722746999cbdd90369a2ccb1,
title = "Impact of cardiac surgery on plasma levels of B-type natriuretic peptide in children with congenital heart disease",
abstract = "OBJECTIVE: To examine prospectively the effect of cardiac surgery on plasma concentration of B-type natriuretic peptide (BNP) in children with congenital heart disease.SETTING: Tertiary referral center.METHODS: BNP plasma concentration was measured by sandwich immunoassay (Biosite) in 65 consecutive patients with congenital heart disease (age 4 days to 17.1 years, mean (S.D.) age 3.6 (4.7) years, median age 1.0 years) on the day before and after surgical therapy. BNP levels were compared to perioperative data and to healthy subjects.RESULTS: BNP increased significantly (p<0.001) after cardiac surgery from median 31 pg/ml (mean 189 pg/ml) to median 453 pg/ml (mean 607 pg/ml) and remained significantly elevated during the first week (p<0.001). After a first peak mean (S.D.) 1.3 (0.7) days after surgery, there was a significant decrease of plasma BNP followed by a second peak 5.1 (1.1) days after surgery. Postoperative BNP plasma concentration was correlated to BNP before surgery (r=0.58, p<0.001), to cardiopulmonary bypass duration (r=0.52, p<0.001) and to serum lactate concentration at the first day after surgery (r=0.49, p<0.001).CONCLUSIONS: In children with congenital heart defects plasma BNP increased immediately after cardiac surgery despite haemodynamic unloading. The correlation to cardiopulmonary bypass time and serum lactate concentration and the similarity between the pattern of BNP release after surgery and after myocardial ischaemia might be explained by a cytoprotective role for BNP after cardiac surgery.",
keywords = "Adolescent, Case-Control Studies, Child, Child, Preschool, Female, Heart Defects, Congenital/blood, Humans, Immunoassay, Infant, Infant, Newborn, Male, Natriuretic Peptide, Brain/blood, Prospective Studies, Statistics, Nonparametric",
author = "Andreas Koch and Tobias Kitzsteiner and Stefan Zink and Robert Cesnjevar and Helmut Singer",
year = "2007",
month = jan,
day = "18",
doi = "10.1016/j.ijcard.2006.01.022",
language = "English",
volume = "114",
pages = "339--344",
journal = "INT J CARDIOL",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Impact of cardiac surgery on plasma levels of B-type natriuretic peptide in children with congenital heart disease

AU - Koch, Andreas

AU - Kitzsteiner, Tobias

AU - Zink, Stefan

AU - Cesnjevar, Robert

AU - Singer, Helmut

PY - 2007/1/18

Y1 - 2007/1/18

N2 - OBJECTIVE: To examine prospectively the effect of cardiac surgery on plasma concentration of B-type natriuretic peptide (BNP) in children with congenital heart disease.SETTING: Tertiary referral center.METHODS: BNP plasma concentration was measured by sandwich immunoassay (Biosite) in 65 consecutive patients with congenital heart disease (age 4 days to 17.1 years, mean (S.D.) age 3.6 (4.7) years, median age 1.0 years) on the day before and after surgical therapy. BNP levels were compared to perioperative data and to healthy subjects.RESULTS: BNP increased significantly (p<0.001) after cardiac surgery from median 31 pg/ml (mean 189 pg/ml) to median 453 pg/ml (mean 607 pg/ml) and remained significantly elevated during the first week (p<0.001). After a first peak mean (S.D.) 1.3 (0.7) days after surgery, there was a significant decrease of plasma BNP followed by a second peak 5.1 (1.1) days after surgery. Postoperative BNP plasma concentration was correlated to BNP before surgery (r=0.58, p<0.001), to cardiopulmonary bypass duration (r=0.52, p<0.001) and to serum lactate concentration at the first day after surgery (r=0.49, p<0.001).CONCLUSIONS: In children with congenital heart defects plasma BNP increased immediately after cardiac surgery despite haemodynamic unloading. The correlation to cardiopulmonary bypass time and serum lactate concentration and the similarity between the pattern of BNP release after surgery and after myocardial ischaemia might be explained by a cytoprotective role for BNP after cardiac surgery.

AB - OBJECTIVE: To examine prospectively the effect of cardiac surgery on plasma concentration of B-type natriuretic peptide (BNP) in children with congenital heart disease.SETTING: Tertiary referral center.METHODS: BNP plasma concentration was measured by sandwich immunoassay (Biosite) in 65 consecutive patients with congenital heart disease (age 4 days to 17.1 years, mean (S.D.) age 3.6 (4.7) years, median age 1.0 years) on the day before and after surgical therapy. BNP levels were compared to perioperative data and to healthy subjects.RESULTS: BNP increased significantly (p<0.001) after cardiac surgery from median 31 pg/ml (mean 189 pg/ml) to median 453 pg/ml (mean 607 pg/ml) and remained significantly elevated during the first week (p<0.001). After a first peak mean (S.D.) 1.3 (0.7) days after surgery, there was a significant decrease of plasma BNP followed by a second peak 5.1 (1.1) days after surgery. Postoperative BNP plasma concentration was correlated to BNP before surgery (r=0.58, p<0.001), to cardiopulmonary bypass duration (r=0.52, p<0.001) and to serum lactate concentration at the first day after surgery (r=0.49, p<0.001).CONCLUSIONS: In children with congenital heart defects plasma BNP increased immediately after cardiac surgery despite haemodynamic unloading. The correlation to cardiopulmonary bypass time and serum lactate concentration and the similarity between the pattern of BNP release after surgery and after myocardial ischaemia might be explained by a cytoprotective role for BNP after cardiac surgery.

KW - Adolescent

KW - Case-Control Studies

KW - Child

KW - Child, Preschool

KW - Female

KW - Heart Defects, Congenital/blood

KW - Humans

KW - Immunoassay

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Natriuretic Peptide, Brain/blood

KW - Prospective Studies

KW - Statistics, Nonparametric

U2 - 10.1016/j.ijcard.2006.01.022

DO - 10.1016/j.ijcard.2006.01.022

M3 - SCORING: Journal article

C2 - 16753233

VL - 114

SP - 339

EP - 344

JO - INT J CARDIOL

JF - INT J CARDIOL

SN - 0167-5273

IS - 3

ER -