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Impact of Anti-T-lymphocyte globulin dosing on GVHD and Immune reconstitution in matched unrelated myeloablative peripheral blood stem cell transplantation

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Impact of Anti-T-lymphocyte globulin dosing on GVHD and Immune reconstitution in matched unrelated myeloablative peripheral blood stem cell transplantation. / Massoud, Radwan; Klyuchnikov, Evgeny; Gagelmann, Nico; Zabelina, Tatiana; Wolschke, Christine; Ayuk, Francis; Fritzsche-Friedland, Ulrike; Zander, Axel; Kröger, Nicolaus.

in: BONE MARROW TRANSPL, Jahrgang 57, Nr. 10, 10.2022, S. 1548-1555.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Massoud, R, Klyuchnikov, E, Gagelmann, N, Zabelina, T, Wolschke, C, Ayuk, F, Fritzsche-Friedland, U, Zander, A & Kröger, N 2022, 'Impact of Anti-T-lymphocyte globulin dosing on GVHD and Immune reconstitution in matched unrelated myeloablative peripheral blood stem cell transplantation', BONE MARROW TRANSPL, Jg. 57, Nr. 10, S. 1548-1555. https://doi.org/10.1038/s41409-022-01666-x

APA

Massoud, R., Klyuchnikov, E., Gagelmann, N., Zabelina, T., Wolschke, C., Ayuk, F., Fritzsche-Friedland, U., Zander, A., & Kröger, N. (2022). Impact of Anti-T-lymphocyte globulin dosing on GVHD and Immune reconstitution in matched unrelated myeloablative peripheral blood stem cell transplantation. BONE MARROW TRANSPL, 57(10), 1548-1555. https://doi.org/10.1038/s41409-022-01666-x

Vancouver

Massoud R, Klyuchnikov E, Gagelmann N, Zabelina T, Wolschke C, Ayuk F et al. Impact of Anti-T-lymphocyte globulin dosing on GVHD and Immune reconstitution in matched unrelated myeloablative peripheral blood stem cell transplantation. BONE MARROW TRANSPL. 2022 Okt;57(10):1548-1555. https://doi.org/10.1038/s41409-022-01666-x

Bibtex

@article{6fb0d75219c344b4bcaebd50696484a8,
title = "Impact of Anti-T-lymphocyte globulin dosing on GVHD and Immune reconstitution in matched unrelated myeloablative peripheral blood stem cell transplantation",
abstract = "Data on the influence of different Anti-lymphocyte globulin (ATLG) doses on graft versus host disease (GVHD) incidence and immune reconstitution in matched unrelated (MUD) allogeneic Stem cell transplantation (allo-SCT) is limited. This retrospective study conducted at the University Medical-Center Hamburg compares GVHD and Immune reconstitution after myeloablative MUD (HLA 10/10) PBSC allogeneic stem cell transplant between 30 mg/Kg (n = 73) and 60 mg/Kg (n = 216) ATLG. Detailed phenotypes of T, B natural killer (NK), natural killer T (NKT) cells were analyzed by multicolor flow at day 30, 100, and 180 posttransplant. Neutrophil and platelet engraftments were significantly delayed in the 60 mg/kg group with a higher Cumulative incidence of Infections (67% vs 75% p = 0.049) and EBV (21% vs 41% p = 0.049) reactivation at day 100 in this group. In the 30 mg/kg group, we observed a faster reconstitution of na{\"i}ve-B cells (p < 0.0001) and γδ T cells (p = 0.045) at day+30 and a faster na{\"i}ve helper T-cell (p = 0.046), NK-cells (p = 0.035), and na{\"i}ve B-cell reconstitution (p = 0.009) at day+180. There were no significant differences in aGVHD, cGVHD, NRM, RI, PFS, and OS between the groups. The choice of ATLG dose has significant impact on IR but not on GVHD after MUD-allo-SCT. Higher doses are associated with delayed engraftment and increased infections.",
author = "Radwan Massoud and Evgeny Klyuchnikov and Nico Gagelmann and Tatiana Zabelina and Christine Wolschke and Francis Ayuk and Ulrike Fritzsche-Friedland and Axel Zander and Nicolaus Kr{\"o}ger",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
month = oct,
doi = "10.1038/s41409-022-01666-x",
language = "English",
volume = "57",
pages = "1548--1555",
journal = "BONE MARROW TRANSPL",
issn = "0268-3369",
publisher = "NATURE PUBLISHING GROUP",
number = "10",

}

RIS

TY - JOUR

T1 - Impact of Anti-T-lymphocyte globulin dosing on GVHD and Immune reconstitution in matched unrelated myeloablative peripheral blood stem cell transplantation

AU - Massoud, Radwan

AU - Klyuchnikov, Evgeny

AU - Gagelmann, Nico

AU - Zabelina, Tatiana

AU - Wolschke, Christine

AU - Ayuk, Francis

AU - Fritzsche-Friedland, Ulrike

AU - Zander, Axel

AU - Kröger, Nicolaus

N1 - © 2022. The Author(s).

PY - 2022/10

Y1 - 2022/10

N2 - Data on the influence of different Anti-lymphocyte globulin (ATLG) doses on graft versus host disease (GVHD) incidence and immune reconstitution in matched unrelated (MUD) allogeneic Stem cell transplantation (allo-SCT) is limited. This retrospective study conducted at the University Medical-Center Hamburg compares GVHD and Immune reconstitution after myeloablative MUD (HLA 10/10) PBSC allogeneic stem cell transplant between 30 mg/Kg (n = 73) and 60 mg/Kg (n = 216) ATLG. Detailed phenotypes of T, B natural killer (NK), natural killer T (NKT) cells were analyzed by multicolor flow at day 30, 100, and 180 posttransplant. Neutrophil and platelet engraftments were significantly delayed in the 60 mg/kg group with a higher Cumulative incidence of Infections (67% vs 75% p = 0.049) and EBV (21% vs 41% p = 0.049) reactivation at day 100 in this group. In the 30 mg/kg group, we observed a faster reconstitution of naïve-B cells (p < 0.0001) and γδ T cells (p = 0.045) at day+30 and a faster naïve helper T-cell (p = 0.046), NK-cells (p = 0.035), and naïve B-cell reconstitution (p = 0.009) at day+180. There were no significant differences in aGVHD, cGVHD, NRM, RI, PFS, and OS between the groups. The choice of ATLG dose has significant impact on IR but not on GVHD after MUD-allo-SCT. Higher doses are associated with delayed engraftment and increased infections.

AB - Data on the influence of different Anti-lymphocyte globulin (ATLG) doses on graft versus host disease (GVHD) incidence and immune reconstitution in matched unrelated (MUD) allogeneic Stem cell transplantation (allo-SCT) is limited. This retrospective study conducted at the University Medical-Center Hamburg compares GVHD and Immune reconstitution after myeloablative MUD (HLA 10/10) PBSC allogeneic stem cell transplant between 30 mg/Kg (n = 73) and 60 mg/Kg (n = 216) ATLG. Detailed phenotypes of T, B natural killer (NK), natural killer T (NKT) cells were analyzed by multicolor flow at day 30, 100, and 180 posttransplant. Neutrophil and platelet engraftments were significantly delayed in the 60 mg/kg group with a higher Cumulative incidence of Infections (67% vs 75% p = 0.049) and EBV (21% vs 41% p = 0.049) reactivation at day 100 in this group. In the 30 mg/kg group, we observed a faster reconstitution of naïve-B cells (p < 0.0001) and γδ T cells (p = 0.045) at day+30 and a faster naïve helper T-cell (p = 0.046), NK-cells (p = 0.035), and naïve B-cell reconstitution (p = 0.009) at day+180. There were no significant differences in aGVHD, cGVHD, NRM, RI, PFS, and OS between the groups. The choice of ATLG dose has significant impact on IR but not on GVHD after MUD-allo-SCT. Higher doses are associated with delayed engraftment and increased infections.

U2 - 10.1038/s41409-022-01666-x

DO - 10.1038/s41409-022-01666-x

M3 - SCORING: Journal article

C2 - 35831408

VL - 57

SP - 1548

EP - 1555

JO - BONE MARROW TRANSPL

JF - BONE MARROW TRANSPL

SN - 0268-3369

IS - 10

ER -