Impact of 2 generational improvements in colonoscopes on adenoma miss rates
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Impact of 2 generational improvements in colonoscopes on adenoma miss rates. / Pioche, Mathieu; Denis, Angelique; Allescher, Hans-Dieter; Andrisani, Gianluca; Costamagna, Guido; Dekker, Evelien; Fockens, Paul; Gerges, Christian; Groth, Stefan; Kandler, Jennis; Lienhart, Isabelle; Neuhaus, Horst; Petruzziello, Lucio; Schachschal, Guido; Tytgat, Kristien; Wallner, Jürgen; Weingart, Vincens; Touzet, Sandrine; Ponchon, Thierry; Rösch, Thomas.
in: GASTROINTEST ENDOSC, Jahrgang 88, Nr. 1, 07.2018, S. 107-116.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Impact of 2 generational improvements in colonoscopes on adenoma miss rates
AU - Pioche, Mathieu
AU - Denis, Angelique
AU - Allescher, Hans-Dieter
AU - Andrisani, Gianluca
AU - Costamagna, Guido
AU - Dekker, Evelien
AU - Fockens, Paul
AU - Gerges, Christian
AU - Groth, Stefan
AU - Kandler, Jennis
AU - Lienhart, Isabelle
AU - Neuhaus, Horst
AU - Petruzziello, Lucio
AU - Schachschal, Guido
AU - Tytgat, Kristien
AU - Wallner, Jürgen
AU - Weingart, Vincens
AU - Touzet, Sandrine
AU - Ponchon, Thierry
AU - Rösch, Thomas
N1 - Copyright © 2018 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.
PY - 2018/7
Y1 - 2018/7
N2 - BACKGROUND AND AIMS: Numerous randomized studies have shown that changing certain features of colonoscopes, usually incorporated when switching from one endoscope generation to the next, mostly do not increase adenoma yield. There is, however, indirect evidence that it may be necessary to skip one instrument generation (ie, changing from one generation to the next but one) to achieve this effect.METHODS: We compared the latest-generation colonoscopes from one company (Olympus Exera III, 190-C) with the next to last one (Olympus 160/5-C) in a prospective multicenter study randomized for the order of colonoscopes in a tandem fashion, involving 2 different examiners. Patients with increased risk for colorectal neoplasia undergoing colonoscopy (positive fecal occult blood test, personal/familial history of colorectal cancer/adenoma, rectal bleeding, recent change in bowel movements) were included. The primary outcome was the adenoma miss rate with the 190 (190-C) colonoscope in comparison with the 160/5 colonoscope (160/5-C).RESULTS: A total of 856 patients (48.8% male; mean age, 58.3 years) with a personal (41%) or family (38%) history of colorectal neoplasia, rectal bleeding (19%), and other indications were included. Of the 429 patients in the 190-C first group, 16.6% (95% confidence interval [CI], 13.0%-20.1%) had at least one adenoma missed during the first procedure, compared with 30.2% (95% CI, 25.9%-34.6%) in the group with 160/5-C first (P < .001). Similarly, the adenoma detection rate during the first colonoscopy was 43.8% versus 36.5% (P = .030) for 190-C versus 160/5-C, respectively.CONCLUSIONS: This randomized tandem trial showed lower adenoma miss rates and higher adenoma detection rates for the newer 190 colonoscopes compared with the 160/5 series. These results suggest that it takes multiple improvements, such as those implemented over 2 instrument generations, before an effect on adenoma (miss) rate can be observed. (Study registration number: ISRCTN 2010-A01256-33.).
AB - BACKGROUND AND AIMS: Numerous randomized studies have shown that changing certain features of colonoscopes, usually incorporated when switching from one endoscope generation to the next, mostly do not increase adenoma yield. There is, however, indirect evidence that it may be necessary to skip one instrument generation (ie, changing from one generation to the next but one) to achieve this effect.METHODS: We compared the latest-generation colonoscopes from one company (Olympus Exera III, 190-C) with the next to last one (Olympus 160/5-C) in a prospective multicenter study randomized for the order of colonoscopes in a tandem fashion, involving 2 different examiners. Patients with increased risk for colorectal neoplasia undergoing colonoscopy (positive fecal occult blood test, personal/familial history of colorectal cancer/adenoma, rectal bleeding, recent change in bowel movements) were included. The primary outcome was the adenoma miss rate with the 190 (190-C) colonoscope in comparison with the 160/5 colonoscope (160/5-C).RESULTS: A total of 856 patients (48.8% male; mean age, 58.3 years) with a personal (41%) or family (38%) history of colorectal neoplasia, rectal bleeding (19%), and other indications were included. Of the 429 patients in the 190-C first group, 16.6% (95% confidence interval [CI], 13.0%-20.1%) had at least one adenoma missed during the first procedure, compared with 30.2% (95% CI, 25.9%-34.6%) in the group with 160/5-C first (P < .001). Similarly, the adenoma detection rate during the first colonoscopy was 43.8% versus 36.5% (P = .030) for 190-C versus 160/5-C, respectively.CONCLUSIONS: This randomized tandem trial showed lower adenoma miss rates and higher adenoma detection rates for the newer 190 colonoscopes compared with the 160/5 series. These results suggest that it takes multiple improvements, such as those implemented over 2 instrument generations, before an effect on adenoma (miss) rate can be observed. (Study registration number: ISRCTN 2010-A01256-33.).
KW - Journal Article
U2 - 10.1016/j.gie.2018.01.025
DO - 10.1016/j.gie.2018.01.025
M3 - SCORING: Journal article
C2 - 29410020
VL - 88
SP - 107
EP - 116
JO - GASTROINTEST ENDOSC
JF - GASTROINTEST ENDOSC
SN - 0016-5107
IS - 1
ER -
