Immunological substrates of depressive symptoms in patients with severe obesity: An exploratory study
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Immunological substrates of depressive symptoms in patients with severe obesity: An exploratory study. / Stiglbauer, Victoria; Gamradt, Stefanie; Scherzer, Marie; Brasanac, Jelena; Otte, Christian; Rose, Matthias; Hofmann, Tobias; Hinkelmann, Kim; Gold, Stefan M.
in: CELL BIOCHEM FUNCT, Jahrgang 39, Nr. 3, 04.2021, S. 423-431.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Immunological substrates of depressive symptoms in patients with severe obesity: An exploratory study
AU - Stiglbauer, Victoria
AU - Gamradt, Stefanie
AU - Scherzer, Marie
AU - Brasanac, Jelena
AU - Otte, Christian
AU - Rose, Matthias
AU - Hofmann, Tobias
AU - Hinkelmann, Kim
AU - Gold, Stefan M
N1 - © 2021 The Authors. Cell Biochemistry and Function published by John Wiley & Sons Ltd.
PY - 2021/4
Y1 - 2021/4
N2 - In this pilot study, we explored the immune phenotype of patients with severe obesity and comorbid depressive symptoms compared to non-depressed patients with obesity and normal-weight controls. Immune cell subsets were analysed by flow cytometry and depressive symptoms assessed using the Patient Health Questionnaire (PHQ-9). Cell frequencies were correlated with depressive symptom scores and waist-to-hip ratio (WHR). Patients with obesity and comorbid depression showed significantly lower numbers of circulating cytotoxic natural killer cells, dendritic cells and CD8+ effector memory T cells, compared to normal-weight controls. Regulatory T cells and CD4+ central memory T cells were increased compared to non-depressed patients with obesity and compared to normal-weight controls, respectively. Frequencies of cytotoxic natural killer cells and CD4+ central memory T cells significantly correlated with PHQ-9 scores, but not with WHR. Reduced numbers of dendritic cells were observed in both patient groups with obesity and correlated with PHQ-9 scores and WHR. These findings provide evidence for an altered immune composition in comorbid obesity and depression, supporting a pathobiological overlap between the two disorders.
AB - In this pilot study, we explored the immune phenotype of patients with severe obesity and comorbid depressive symptoms compared to non-depressed patients with obesity and normal-weight controls. Immune cell subsets were analysed by flow cytometry and depressive symptoms assessed using the Patient Health Questionnaire (PHQ-9). Cell frequencies were correlated with depressive symptom scores and waist-to-hip ratio (WHR). Patients with obesity and comorbid depression showed significantly lower numbers of circulating cytotoxic natural killer cells, dendritic cells and CD8+ effector memory T cells, compared to normal-weight controls. Regulatory T cells and CD4+ central memory T cells were increased compared to non-depressed patients with obesity and compared to normal-weight controls, respectively. Frequencies of cytotoxic natural killer cells and CD4+ central memory T cells significantly correlated with PHQ-9 scores, but not with WHR. Reduced numbers of dendritic cells were observed in both patient groups with obesity and correlated with PHQ-9 scores and WHR. These findings provide evidence for an altered immune composition in comorbid obesity and depression, supporting a pathobiological overlap between the two disorders.
U2 - 10.1002/cbf.3608
DO - 10.1002/cbf.3608
M3 - SCORING: Journal article
C2 - 33401342
VL - 39
SP - 423
EP - 431
JO - CELL BIOCHEM FUNCT
JF - CELL BIOCHEM FUNCT
SN - 0263-6484
IS - 3
ER -
