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Immunoglobulins and virus-specific antibodies in patients with Creutzfeldt-Jakob disease.

Standard

Immunoglobulins and virus-specific antibodies in patients with Creutzfeldt-Jakob disease. / Jacobi, C; Arlt, Sönke; Reiber, H; Westner, I; Kretzschmar, H A; Poser, S; Zerr, I.

in: ACTA NEUROL SCAND, Jahrgang 111, Nr. 3, 3, 2005, S. 185-190.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Jacobi, C, Arlt, S, Reiber, H, Westner, I, Kretzschmar, HA, Poser, S & Zerr, I 2005, 'Immunoglobulins and virus-specific antibodies in patients with Creutzfeldt-Jakob disease.', ACTA NEUROL SCAND, Jg. 111, Nr. 3, 3, S. 185-190. <http://www.ncbi.nlm.nih.gov/pubmed/15691288?dopt=Citation>

APA

Jacobi, C., Arlt, S., Reiber, H., Westner, I., Kretzschmar, H. A., Poser, S., & Zerr, I. (2005). Immunoglobulins and virus-specific antibodies in patients with Creutzfeldt-Jakob disease. ACTA NEUROL SCAND, 111(3), 185-190. [3]. http://www.ncbi.nlm.nih.gov/pubmed/15691288?dopt=Citation

Vancouver

Jacobi C, Arlt S, Reiber H, Westner I, Kretzschmar HA, Poser S et al. Immunoglobulins and virus-specific antibodies in patients with Creutzfeldt-Jakob disease. ACTA NEUROL SCAND. 2005;111(3):185-190. 3.

Bibtex

@article{5fdd58d1f6e849aa887b37ce886cf373,
title = "Immunoglobulins and virus-specific antibodies in patients with Creutzfeldt-Jakob disease.",
abstract = "OBJECTIVES: Cerebrospinal fluid (CSF) pattern in patients with neuropathologically diagnosed Creutzfeldt-Jakob disease was analyzed. MATERIAL AND METHODS: Routine tests included white blood cells count, protein, albumin, immunoglobulins and the presence of oligoclonal immunoglobulin G (IgG) in the CSF as well as the calculation of intrathecal synthesis of immunoglobulins by standard methods. In addition, antibodies against neurotropic viruses such as measles, rubella, varicella zoster and herpes simplex were measured and the specific antibody index was calculated. RESULTS: A blood-CSF barrier dysfunction was observed in six of 25 cases. In CSF/serum quotient diagrams, no patient had intrathecally synthesized immunoglobulins, but in two of 25 patients oligoclonal bands were detected. Two patients had intrathecally synthesized antibodies against varicella zoster and three against herpes simplex virus. CONCLUSION: In conclusion, in the routine diagnosis, the CSF in CJD is normal in most cases. In some patients, abnormalities include the blood-CSF barrier dysfunction, mild pleocytosis, oligoclonal bands and intrathecally synthesized viral antibodies.",
author = "C Jacobi and S{\"o}nke Arlt and H Reiber and I Westner and Kretzschmar, {H A} and S Poser and I Zerr",
year = "2005",
language = "Deutsch",
volume = "111",
pages = "185--190",
journal = "ACTA NEUROL SCAND",
issn = "0001-6314",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Immunoglobulins and virus-specific antibodies in patients with Creutzfeldt-Jakob disease.

AU - Jacobi, C

AU - Arlt, Sönke

AU - Reiber, H

AU - Westner, I

AU - Kretzschmar, H A

AU - Poser, S

AU - Zerr, I

PY - 2005

Y1 - 2005

N2 - OBJECTIVES: Cerebrospinal fluid (CSF) pattern in patients with neuropathologically diagnosed Creutzfeldt-Jakob disease was analyzed. MATERIAL AND METHODS: Routine tests included white blood cells count, protein, albumin, immunoglobulins and the presence of oligoclonal immunoglobulin G (IgG) in the CSF as well as the calculation of intrathecal synthesis of immunoglobulins by standard methods. In addition, antibodies against neurotropic viruses such as measles, rubella, varicella zoster and herpes simplex were measured and the specific antibody index was calculated. RESULTS: A blood-CSF barrier dysfunction was observed in six of 25 cases. In CSF/serum quotient diagrams, no patient had intrathecally synthesized immunoglobulins, but in two of 25 patients oligoclonal bands were detected. Two patients had intrathecally synthesized antibodies against varicella zoster and three against herpes simplex virus. CONCLUSION: In conclusion, in the routine diagnosis, the CSF in CJD is normal in most cases. In some patients, abnormalities include the blood-CSF barrier dysfunction, mild pleocytosis, oligoclonal bands and intrathecally synthesized viral antibodies.

AB - OBJECTIVES: Cerebrospinal fluid (CSF) pattern in patients with neuropathologically diagnosed Creutzfeldt-Jakob disease was analyzed. MATERIAL AND METHODS: Routine tests included white blood cells count, protein, albumin, immunoglobulins and the presence of oligoclonal immunoglobulin G (IgG) in the CSF as well as the calculation of intrathecal synthesis of immunoglobulins by standard methods. In addition, antibodies against neurotropic viruses such as measles, rubella, varicella zoster and herpes simplex were measured and the specific antibody index was calculated. RESULTS: A blood-CSF barrier dysfunction was observed in six of 25 cases. In CSF/serum quotient diagrams, no patient had intrathecally synthesized immunoglobulins, but in two of 25 patients oligoclonal bands were detected. Two patients had intrathecally synthesized antibodies against varicella zoster and three against herpes simplex virus. CONCLUSION: In conclusion, in the routine diagnosis, the CSF in CJD is normal in most cases. In some patients, abnormalities include the blood-CSF barrier dysfunction, mild pleocytosis, oligoclonal bands and intrathecally synthesized viral antibodies.

M3 - SCORING: Zeitschriftenaufsatz

VL - 111

SP - 185

EP - 190

JO - ACTA NEUROL SCAND

JF - ACTA NEUROL SCAND

SN - 0001-6314

IS - 3

M1 - 3

ER -