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Immune-mediated activation of the endocannabinoid system in visceral adipose tissue in obesity.

Standard

Immune-mediated activation of the endocannabinoid system in visceral adipose tissue in obesity. / Kempf, K; Hector, J; Strate, Tim; Schwarzloh, B; Rose, B; Herder, C; Martin, S; Algenstaedt, Petra.

in: HORM METAB RES, Jahrgang 39, Nr. 8, 8, 2007, S. 596-600.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kempf, K, Hector, J, Strate, T, Schwarzloh, B, Rose, B, Herder, C, Martin, S & Algenstaedt, P 2007, 'Immune-mediated activation of the endocannabinoid system in visceral adipose tissue in obesity.', HORM METAB RES, Jg. 39, Nr. 8, 8, S. 596-600. <http://www.ncbi.nlm.nih.gov/pubmed/17712725?dopt=Citation>

APA

Kempf, K., Hector, J., Strate, T., Schwarzloh, B., Rose, B., Herder, C., Martin, S., & Algenstaedt, P. (2007). Immune-mediated activation of the endocannabinoid system in visceral adipose tissue in obesity. HORM METAB RES, 39(8), 596-600. [8]. http://www.ncbi.nlm.nih.gov/pubmed/17712725?dopt=Citation

Vancouver

Kempf K, Hector J, Strate T, Schwarzloh B, Rose B, Herder C et al. Immune-mediated activation of the endocannabinoid system in visceral adipose tissue in obesity. HORM METAB RES. 2007;39(8):596-600. 8.

Bibtex

@article{bee968eeba8846eb9b357de6a8f86697,
title = "Immune-mediated activation of the endocannabinoid system in visceral adipose tissue in obesity.",
abstract = "The aim of the study was to investigate if the endocannabinoid system (ECS) is activated in visceral adipose tissue and if adipose tissue inflammation affects the ECS activation state. Therefore, expression of fatty acid amide hydrolase (FAAH), cannabinoid receptor 1 (Cb1), adiponectin, and tumor necrosis factor (TNF)-alpha was compared in visceral adipose tissue from 10 normal-weight (BMI 24.4+/-1.1 kg/m2) and 11 obese subjects (BMI 37.6+/-13.6 kg/m2) using quantitative RT-PCR, and gene expression changes were analyzed after in vitro stimulation of visceral adipose tissue with TNF-alpha. The data demonstrate that the ECS is activated in obese visceral adipose tissue as shown by decreased FAAH, Cb1, and adiponectin expression. Obesity-related ECS activation is accompanied by elevated expression of the pro-inflammatory cytokine TNF-alpha, which in turn stimulates ECS activation in vitro. Our data show a strong association between adipose tissue inflammation and ECS activation in obesity, and indicate that a pro-inflammatory state may directly activate the ECS.",
author = "K Kempf and J Hector and Tim Strate and B Schwarzloh and B Rose and C Herder and S Martin and Petra Algenstaedt",
year = "2007",
language = "Deutsch",
volume = "39",
pages = "596--600",
journal = "HORM METAB RES",
issn = "0018-5043",
publisher = "Georg Thieme Verlag KG",
number = "8",

}

RIS

TY - JOUR

T1 - Immune-mediated activation of the endocannabinoid system in visceral adipose tissue in obesity.

AU - Kempf, K

AU - Hector, J

AU - Strate, Tim

AU - Schwarzloh, B

AU - Rose, B

AU - Herder, C

AU - Martin, S

AU - Algenstaedt, Petra

PY - 2007

Y1 - 2007

N2 - The aim of the study was to investigate if the endocannabinoid system (ECS) is activated in visceral adipose tissue and if adipose tissue inflammation affects the ECS activation state. Therefore, expression of fatty acid amide hydrolase (FAAH), cannabinoid receptor 1 (Cb1), adiponectin, and tumor necrosis factor (TNF)-alpha was compared in visceral adipose tissue from 10 normal-weight (BMI 24.4+/-1.1 kg/m2) and 11 obese subjects (BMI 37.6+/-13.6 kg/m2) using quantitative RT-PCR, and gene expression changes were analyzed after in vitro stimulation of visceral adipose tissue with TNF-alpha. The data demonstrate that the ECS is activated in obese visceral adipose tissue as shown by decreased FAAH, Cb1, and adiponectin expression. Obesity-related ECS activation is accompanied by elevated expression of the pro-inflammatory cytokine TNF-alpha, which in turn stimulates ECS activation in vitro. Our data show a strong association between adipose tissue inflammation and ECS activation in obesity, and indicate that a pro-inflammatory state may directly activate the ECS.

AB - The aim of the study was to investigate if the endocannabinoid system (ECS) is activated in visceral adipose tissue and if adipose tissue inflammation affects the ECS activation state. Therefore, expression of fatty acid amide hydrolase (FAAH), cannabinoid receptor 1 (Cb1), adiponectin, and tumor necrosis factor (TNF)-alpha was compared in visceral adipose tissue from 10 normal-weight (BMI 24.4+/-1.1 kg/m2) and 11 obese subjects (BMI 37.6+/-13.6 kg/m2) using quantitative RT-PCR, and gene expression changes were analyzed after in vitro stimulation of visceral adipose tissue with TNF-alpha. The data demonstrate that the ECS is activated in obese visceral adipose tissue as shown by decreased FAAH, Cb1, and adiponectin expression. Obesity-related ECS activation is accompanied by elevated expression of the pro-inflammatory cytokine TNF-alpha, which in turn stimulates ECS activation in vitro. Our data show a strong association between adipose tissue inflammation and ECS activation in obesity, and indicate that a pro-inflammatory state may directly activate the ECS.

M3 - SCORING: Zeitschriftenaufsatz

VL - 39

SP - 596

EP - 600

JO - HORM METAB RES

JF - HORM METAB RES

SN - 0018-5043

IS - 8

M1 - 8

ER -