Immune status, psychosocial distress and reduced quality of life in infertile patients with endometriosis.
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Immune status, psychosocial distress and reduced quality of life in infertile patients with endometriosis. / Siedentopf, Friederike; Tariverdian, Nadja; Rücke, Mirjam; Kentenich, Heribert; Arck, Petra.
in: AM J REPROD IMMUNOL, Jahrgang 60, Nr. 5, 5, 2008, S. 449-461.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Immune status, psychosocial distress and reduced quality of life in infertile patients with endometriosis.
AU - Siedentopf, Friederike
AU - Tariverdian, Nadja
AU - Rücke, Mirjam
AU - Kentenich, Heribert
AU - Arck, Petra
PY - 2008
Y1 - 2008
N2 - PROBLEM: The aim of the study was to identify if (i) psychosocial factors differ in endometriosis; (ii) related psychosocial aspects alter immune markers of depression/sickness behaviour; and (iii) serum immune marker may be indicative for endometriosis. METHOD OF STUDY: We enrolled 103 women in a case-control study. Psychosocial data were obtained, serum levels of interleukin (IL)-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, interferon (IFN)-gamma, TNF-alpha, IFN-alpha and soluble intercellular adhesion molecule-1 (sICAM-1) were analysed. RESULTS: Among 69 eligible patients, endometriosis was diagnosed in 38 women. Patients with endometriosis reported reduced quality of life, increased stress perception/depressive symptoms; the Th1/Th2 ratio was in favour of Th1, accompanied by the increased levels of IFN-alpha. sICAM-1 levels were unaffected. No correlation could be confirmed between psychosocial and immune markers. CONCLUSION: Women with endometriosis may benefit from strategies contributing to reduction of stress and development of coping mechanisms, thus helping to break the vicious circle of inflammation, sickness behaviour and depression.
AB - PROBLEM: The aim of the study was to identify if (i) psychosocial factors differ in endometriosis; (ii) related psychosocial aspects alter immune markers of depression/sickness behaviour; and (iii) serum immune marker may be indicative for endometriosis. METHOD OF STUDY: We enrolled 103 women in a case-control study. Psychosocial data were obtained, serum levels of interleukin (IL)-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, interferon (IFN)-gamma, TNF-alpha, IFN-alpha and soluble intercellular adhesion molecule-1 (sICAM-1) were analysed. RESULTS: Among 69 eligible patients, endometriosis was diagnosed in 38 women. Patients with endometriosis reported reduced quality of life, increased stress perception/depressive symptoms; the Th1/Th2 ratio was in favour of Th1, accompanied by the increased levels of IFN-alpha. sICAM-1 levels were unaffected. No correlation could be confirmed between psychosocial and immune markers. CONCLUSION: Women with endometriosis may benefit from strategies contributing to reduction of stress and development of coping mechanisms, thus helping to break the vicious circle of inflammation, sickness behaviour and depression.
M3 - SCORING: Zeitschriftenaufsatz
VL - 60
SP - 449
EP - 461
JO - AM J REPROD IMMUNOL
JF - AM J REPROD IMMUNOL
SN - 1046-7408
IS - 5
M1 - 5
ER -
