Imaging movement-related activity in medicated Parkin-associated and sporadic Parkinson's disease.
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Imaging movement-related activity in medicated Parkin-associated and sporadic Parkinson's disease. / van Eimeren, Thilo; Binkofski, Ferdinand; Buhmann, Carsten; Hagenah, Johann; Strafella, Antonio P; Pramstaller, Peter P; Siebner, Hartwig R; Klein, Christine.
in: PARKINSONISM RELAT D, Jahrgang 16, Nr. 6, 6, 2010, S. 384-387.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Imaging movement-related activity in medicated Parkin-associated and sporadic Parkinson's disease.
AU - van Eimeren, Thilo
AU - Binkofski, Ferdinand
AU - Buhmann, Carsten
AU - Hagenah, Johann
AU - Strafella, Antonio P
AU - Pramstaller, Peter P
AU - Siebner, Hartwig R
AU - Klein, Christine
PY - 2010
Y1 - 2010
N2 - Treatment-related motor complications such as dyskinesias are a major problem in the long-term management of Parkinson's disease (PD). In sporadic PD, a relatively early onset of the disease is known to be associated with an early development of dyskinesias. Although linked with early onset, patients with Parkin-associated PD often show a stable long-term response to dopaminergic therapy without developing treatment-induced motor complications. Therefore, we reasoned that this difference in vulnerability to develop dyskinesias under long-term dopaminergic therapy may be associated with differences in movement-related activation patterns in Parkin-associated compared to sporadic PD. To test this hypothesis, medicated non-dyskinetic patients with either Parkin-associated or sporadic PD underwent functional magnetic resonance imaging (fMRI) while performing externally specified or internally selected movements. Patients with Parkin-associated and sporadic PD showed no difference in movement-related activation patterns. Moreover, the covariates 'age' and 'disease duration' similarly influenced brain activation in both patient groups. The present finding suggests that a stable long-term motor response in some patients with Parkin-associated PD may not be related to differences in cortical recruitment. In conclusion, our findings corroborate a substantial pathophysiologic overlap between Parkin-associated and sporadic PD and lend further support to the notion that Parkin-associated PD is a suitable genetic model for sporadic PD.
AB - Treatment-related motor complications such as dyskinesias are a major problem in the long-term management of Parkinson's disease (PD). In sporadic PD, a relatively early onset of the disease is known to be associated with an early development of dyskinesias. Although linked with early onset, patients with Parkin-associated PD often show a stable long-term response to dopaminergic therapy without developing treatment-induced motor complications. Therefore, we reasoned that this difference in vulnerability to develop dyskinesias under long-term dopaminergic therapy may be associated with differences in movement-related activation patterns in Parkin-associated compared to sporadic PD. To test this hypothesis, medicated non-dyskinetic patients with either Parkin-associated or sporadic PD underwent functional magnetic resonance imaging (fMRI) while performing externally specified or internally selected movements. Patients with Parkin-associated and sporadic PD showed no difference in movement-related activation patterns. Moreover, the covariates 'age' and 'disease duration' similarly influenced brain activation in both patient groups. The present finding suggests that a stable long-term motor response in some patients with Parkin-associated PD may not be related to differences in cortical recruitment. In conclusion, our findings corroborate a substantial pathophysiologic overlap between Parkin-associated and sporadic PD and lend further support to the notion that Parkin-associated PD is a suitable genetic model for sporadic PD.
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Magnetic Resonance Imaging
KW - Mutation
KW - Brain Mapping
KW - Parkinson Disease genetics
KW - Image Interpretation, Computer-Assisted
KW - Brain physiopathology
KW - Dyskinesias genetics
KW - Movement physiology
KW - Ubiquitin-Protein Ligases genetics
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Magnetic Resonance Imaging
KW - Mutation
KW - Brain Mapping
KW - Parkinson Disease genetics
KW - Image Interpretation, Computer-Assisted
KW - Brain physiopathology
KW - Dyskinesias genetics
KW - Movement physiology
KW - Ubiquitin-Protein Ligases genetics
M3 - SCORING: Zeitschriftenaufsatz
VL - 16
SP - 384
EP - 387
JO - PARKINSONISM RELAT D
JF - PARKINSONISM RELAT D
SN - 1353-8020
IS - 6
M1 - 6
ER -
