Imaging alterations of cardiomyocyte cAMP microdomains in disease

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Imaging alterations of cardiomyocyte cAMP microdomains in disease. / Froese, Alexander; Nikolaev, Viacheslav O.

in: FRONT PHARMACOL, Jahrgang 6, 25.08.2015, S. Art. 172.

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Bibtex

@article{2a690cd2b9654ae98312329141eed988,
title = "Imaging alterations of cardiomyocyte cAMP microdomains in disease",
abstract = "3',5'-cyclic adenosine monophosphate (cAMP) is an important second messenger which regulates heart function by acting in distinct subcellular microdomains. Recent years have provided deeper mechanistic insights into compartmentalized cAMP signaling and its link to cardiac disease. In this mini review, we summarize newest developments in this field achieved by cutting-edge biochemical and biophysical techniques. We further compile the data from different studies into a bigger picture of so far uncovered alterations in cardiomyocyte cAMP microdomains which occur in compensated cardiac hypertrophy and chronic heart failure. Finally, future research directions and translational perspectives are briefly discussed.",
author = "Alexander Froese and Nikolaev, {Viacheslav O}",
year = "2015",
month = aug,
day = "25",
doi = "10.3389/fphar.2015.00172",
language = "English",
volume = "6",
pages = "Art. 172",
journal = "FRONT PHARMACOL",
issn = "1663-9812",
publisher = "Frontiers Media S. A.",

}

RIS

TY - JOUR

T1 - Imaging alterations of cardiomyocyte cAMP microdomains in disease

AU - Froese, Alexander

AU - Nikolaev, Viacheslav O

PY - 2015/8/25

Y1 - 2015/8/25

N2 - 3',5'-cyclic adenosine monophosphate (cAMP) is an important second messenger which regulates heart function by acting in distinct subcellular microdomains. Recent years have provided deeper mechanistic insights into compartmentalized cAMP signaling and its link to cardiac disease. In this mini review, we summarize newest developments in this field achieved by cutting-edge biochemical and biophysical techniques. We further compile the data from different studies into a bigger picture of so far uncovered alterations in cardiomyocyte cAMP microdomains which occur in compensated cardiac hypertrophy and chronic heart failure. Finally, future research directions and translational perspectives are briefly discussed.

AB - 3',5'-cyclic adenosine monophosphate (cAMP) is an important second messenger which regulates heart function by acting in distinct subcellular microdomains. Recent years have provided deeper mechanistic insights into compartmentalized cAMP signaling and its link to cardiac disease. In this mini review, we summarize newest developments in this field achieved by cutting-edge biochemical and biophysical techniques. We further compile the data from different studies into a bigger picture of so far uncovered alterations in cardiomyocyte cAMP microdomains which occur in compensated cardiac hypertrophy and chronic heart failure. Finally, future research directions and translational perspectives are briefly discussed.

U2 - 10.3389/fphar.2015.00172

DO - 10.3389/fphar.2015.00172

M3 - SCORING: Journal article

C2 - 26379548

VL - 6

SP - Art. 172

JO - FRONT PHARMACOL

JF - FRONT PHARMACOL

SN - 1663-9812

ER -