Imaging alterations of cardiomyocyte cAMP microdomains in disease
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Imaging alterations of cardiomyocyte cAMP microdomains in disease. / Froese, Alexander; Nikolaev, Viacheslav O.
in: FRONT PHARMACOL, Jahrgang 6, 25.08.2015, S. Art. 172.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Imaging alterations of cardiomyocyte cAMP microdomains in disease
AU - Froese, Alexander
AU - Nikolaev, Viacheslav O
PY - 2015/8/25
Y1 - 2015/8/25
N2 - 3',5'-cyclic adenosine monophosphate (cAMP) is an important second messenger which regulates heart function by acting in distinct subcellular microdomains. Recent years have provided deeper mechanistic insights into compartmentalized cAMP signaling and its link to cardiac disease. In this mini review, we summarize newest developments in this field achieved by cutting-edge biochemical and biophysical techniques. We further compile the data from different studies into a bigger picture of so far uncovered alterations in cardiomyocyte cAMP microdomains which occur in compensated cardiac hypertrophy and chronic heart failure. Finally, future research directions and translational perspectives are briefly discussed.
AB - 3',5'-cyclic adenosine monophosphate (cAMP) is an important second messenger which regulates heart function by acting in distinct subcellular microdomains. Recent years have provided deeper mechanistic insights into compartmentalized cAMP signaling and its link to cardiac disease. In this mini review, we summarize newest developments in this field achieved by cutting-edge biochemical and biophysical techniques. We further compile the data from different studies into a bigger picture of so far uncovered alterations in cardiomyocyte cAMP microdomains which occur in compensated cardiac hypertrophy and chronic heart failure. Finally, future research directions and translational perspectives are briefly discussed.
U2 - 10.3389/fphar.2015.00172
DO - 10.3389/fphar.2015.00172
M3 - SCORING: Journal article
C2 - 26379548
VL - 6
SP - Art. 172
JO - FRONT PHARMACOL
JF - FRONT PHARMACOL
SN - 1663-9812
ER -