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Image-Guided Surgery: Are We Getting the Most Out of Small-Molecule Prostate-Specific-Membrane-Antigen-Targeted Tracers?

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Image-Guided Surgery: Are We Getting the Most Out of Small-Molecule Prostate-Specific-Membrane-Antigen-Targeted Tracers? / Hensbergen, Albertus Wijnand; van Willigen, Danny M; van Beurden, Florian; van Leeuwen, Pim J; Buckle, Tessa; Schottelius, Margret; Maurer, Tobias; Wester, Hans-Jürgen; van Leeuwen, Fijs W B.

in: BIOCONJUGATE CHEM, Jahrgang 31, Nr. 2, 19.02.2020, S. 375-395.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Hensbergen, AW, van Willigen, DM, van Beurden, F, van Leeuwen, PJ, Buckle, T, Schottelius, M, Maurer, T, Wester, H-J & van Leeuwen, FWB 2020, 'Image-Guided Surgery: Are We Getting the Most Out of Small-Molecule Prostate-Specific-Membrane-Antigen-Targeted Tracers?', BIOCONJUGATE CHEM, Jg. 31, Nr. 2, S. 375-395. https://doi.org/10.1021/acs.bioconjchem.9b00758

APA

Hensbergen, A. W., van Willigen, D. M., van Beurden, F., van Leeuwen, P. J., Buckle, T., Schottelius, M., Maurer, T., Wester, H-J., & van Leeuwen, F. W. B. (2020). Image-Guided Surgery: Are We Getting the Most Out of Small-Molecule Prostate-Specific-Membrane-Antigen-Targeted Tracers? BIOCONJUGATE CHEM, 31(2), 375-395. https://doi.org/10.1021/acs.bioconjchem.9b00758

Vancouver

Hensbergen AW, van Willigen DM, van Beurden F, van Leeuwen PJ, Buckle T, Schottelius M et al. Image-Guided Surgery: Are We Getting the Most Out of Small-Molecule Prostate-Specific-Membrane-Antigen-Targeted Tracers? BIOCONJUGATE CHEM. 2020 Feb 19;31(2):375-395. https://doi.org/10.1021/acs.bioconjchem.9b00758

Bibtex

@article{040e1cb6865b49afa38f91f4f8d5032a,
title = "Image-Guided Surgery: Are We Getting the Most Out of Small-Molecule Prostate-Specific-Membrane-Antigen-Targeted Tracers?",
abstract = "Expressed on virtually all prostate cancers and their metastases, the transmembrane protein prostate-specific membrane antigen (PSMA) provides a valuable target for the imaging of prostate cancer. Not only does PSMA provide a target for noninvasive diagnostic imaging, e.g., PSMA-positron emission tomography (PSMA-PET), it can also be used to guide surgical resections of PSMA-positive lesions. The latter characteristic has led to the development of a plethora of PSMA-targeted tracers, i.e., radiolabeled, fluorescent, or hybrid. With image-guided surgery applications in mind, this review discusses these compounds based on clinical need. Here, the focus is on the chemical aspects (e.g., imaging label, spacer moiety, and targeting vector) and their impact on in vitro and in vivo tracer characteristics (e.g., affinity, tumor uptake, and clearance pattern).",
author = "Hensbergen, {Albertus Wijnand} and {van Willigen}, {Danny M} and {van Beurden}, Florian and {van Leeuwen}, {Pim J} and Tessa Buckle and Margret Schottelius and Tobias Maurer and Hans-J{\"u}rgen Wester and {van Leeuwen}, {Fijs W B}",
year = "2020",
month = feb,
day = "19",
doi = "10.1021/acs.bioconjchem.9b00758",
language = "English",
volume = "31",
pages = "375--395",
journal = "BIOCONJUGATE CHEM",
issn = "1043-1802",
publisher = "American Chemical Society",
number = "2",

}

RIS

TY - JOUR

T1 - Image-Guided Surgery: Are We Getting the Most Out of Small-Molecule Prostate-Specific-Membrane-Antigen-Targeted Tracers?

AU - Hensbergen, Albertus Wijnand

AU - van Willigen, Danny M

AU - van Beurden, Florian

AU - van Leeuwen, Pim J

AU - Buckle, Tessa

AU - Schottelius, Margret

AU - Maurer, Tobias

AU - Wester, Hans-Jürgen

AU - van Leeuwen, Fijs W B

PY - 2020/2/19

Y1 - 2020/2/19

N2 - Expressed on virtually all prostate cancers and their metastases, the transmembrane protein prostate-specific membrane antigen (PSMA) provides a valuable target for the imaging of prostate cancer. Not only does PSMA provide a target for noninvasive diagnostic imaging, e.g., PSMA-positron emission tomography (PSMA-PET), it can also be used to guide surgical resections of PSMA-positive lesions. The latter characteristic has led to the development of a plethora of PSMA-targeted tracers, i.e., radiolabeled, fluorescent, or hybrid. With image-guided surgery applications in mind, this review discusses these compounds based on clinical need. Here, the focus is on the chemical aspects (e.g., imaging label, spacer moiety, and targeting vector) and their impact on in vitro and in vivo tracer characteristics (e.g., affinity, tumor uptake, and clearance pattern).

AB - Expressed on virtually all prostate cancers and their metastases, the transmembrane protein prostate-specific membrane antigen (PSMA) provides a valuable target for the imaging of prostate cancer. Not only does PSMA provide a target for noninvasive diagnostic imaging, e.g., PSMA-positron emission tomography (PSMA-PET), it can also be used to guide surgical resections of PSMA-positive lesions. The latter characteristic has led to the development of a plethora of PSMA-targeted tracers, i.e., radiolabeled, fluorescent, or hybrid. With image-guided surgery applications in mind, this review discusses these compounds based on clinical need. Here, the focus is on the chemical aspects (e.g., imaging label, spacer moiety, and targeting vector) and their impact on in vitro and in vivo tracer characteristics (e.g., affinity, tumor uptake, and clearance pattern).

U2 - 10.1021/acs.bioconjchem.9b00758

DO - 10.1021/acs.bioconjchem.9b00758

M3 - SCORING: Review article

C2 - 31855410

VL - 31

SP - 375

EP - 395

JO - BIOCONJUGATE CHEM

JF - BIOCONJUGATE CHEM

SN - 1043-1802

IS - 2

ER -