IL-10-producing T cells and their dual functions
Beteiligte Einrichtungen
Abstract
Interleukin (IL)-10 is considered a prototypical anti-inflammatory cytokine, which significantly contributes to the maintenance and reestablishment of immune homeostasis. However, this classical view fails to fully describe the pleiotropic roles of IL-10. Indeed, IL-10 can also promote immune responses, e.g. by supporting B-cell and CD8+ T-cell activation. The reasons for these seemingly opposing functions are unclear to a large extent. Recent and previous studies suggest that the cellular source and the microenvironment impact the function of IL-10. However, studies addressing the mechanisms which determine whether IL-10 promotes inflammation or controls it have just begun. This review first summarizes the recent findings on the heterogeneity of IL-10 producing T cells and their impact on the target cells. Finally, we will propose two possible explanations for the dual functions of IL-10.
Bibliografische Daten
Originalsprache | Englisch |
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ISSN | 1044-5323 |
DOIs | |
Status | Veröffentlicht - 08.2019 |
Anmerkungen des Dekanats
Copyright © 2019 Elsevier Ltd. All rights reserved.
PubMed | 31734129 |
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