IgG4 Characteristics and Functions in Cancer Immunity
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IgG4 Characteristics and Functions in Cancer Immunity. / Crescioli, Silvia; Correa, Isabel; Karagiannis, Panagiotis; Davies, Anna M; Sutton, Brian J; Nestle, Frank O; Karagiannis, Sophia N.
in: CURR ALLERGY ASTHM R, Jahrgang 16, Nr. 1, 01.2016, S. 7.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - IgG4 Characteristics and Functions in Cancer Immunity
AU - Crescioli, Silvia
AU - Correa, Isabel
AU - Karagiannis, Panagiotis
AU - Davies, Anna M
AU - Sutton, Brian J
AU - Nestle, Frank O
AU - Karagiannis, Sophia N
PY - 2016/1
Y1 - 2016/1
N2 - IgG4 is the least abundant subclass of IgG in normal human serum, but elevated IgG4 levels are triggered in response to a chronic antigenic stimulus and inflammation. Since the immune system is exposed to tumor-associated antigens over a relatively long period of time, and tumors notoriously promote inflammation, it is unsurprising that IgG4 has been implicated in certain tumor types. Despite differing from other IgG subclasses by only a few amino acids, IgG4 possesses unique structural characteristics that may be responsible for its poor effector function potency and immunomodulatory properties. We describe the unique attributes of IgG4 that may be responsible for these regulatory functions, particularly in the cancer context. We discuss the inflammatory conditions in tumors that support IgG4, the emerging and proposed mechanisms by which IgG4 may contribute to tumor-associated escape from immune surveillance and implications for cancer immunotherapy.
AB - IgG4 is the least abundant subclass of IgG in normal human serum, but elevated IgG4 levels are triggered in response to a chronic antigenic stimulus and inflammation. Since the immune system is exposed to tumor-associated antigens over a relatively long period of time, and tumors notoriously promote inflammation, it is unsurprising that IgG4 has been implicated in certain tumor types. Despite differing from other IgG subclasses by only a few amino acids, IgG4 possesses unique structural characteristics that may be responsible for its poor effector function potency and immunomodulatory properties. We describe the unique attributes of IgG4 that may be responsible for these regulatory functions, particularly in the cancer context. We discuss the inflammatory conditions in tumors that support IgG4, the emerging and proposed mechanisms by which IgG4 may contribute to tumor-associated escape from immune surveillance and implications for cancer immunotherapy.
KW - Antigens, Neoplasm
KW - Humans
KW - Immunoglobulin G
KW - Neoplasms
KW - Tumor Escape
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
KW - Review
U2 - 10.1007/s11882-015-0580-7
DO - 10.1007/s11882-015-0580-7
M3 - SCORING: Journal article
C2 - 26742760
VL - 16
SP - 7
JO - CURR ALLERGY ASTHM R
JF - CURR ALLERGY ASTHM R
SN - 1529-7322
IS - 1
ER -